4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: First boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity

4,7-Dichloro-1-benzothien-2-yl sulfonylaminomethyl boronic acid (DSABA, Compound I) was discovered as the first boronic acid-based class D beta-lactamase inhibitor. It exhibited an IC50 of 5.6 mu M against OXA-40. The compound also inhibited class A and C beta-lactamases with sub to low mu M IC50, and synergized with imipenem against Acinetobacter baumannii. (C) 2010 Elsevier Ltd. All rights reserved.