期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 12, 页码 3698-3702出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.04.084
关键词
1,3-Dipolar cycloaddition; beta-Lactam; Spiroisoxazolidine; Microwave
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi, India
- Department of Science and Technology (DST-FIRST)
Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones ring systems has been achieved by intermolecular 1,3-dipolar cycloaddition reaction of bicyclic nitrone with unusual dipolarophiles, arylidene chromanones/tetralones under different reaction conditions. The synthesized compounds were evaluated for antimicrobial activities. It was observed that two of the synthesized compounds exhibited relatively good antibacterial and antifungal activities. (C) 2010 Elsevier Ltd. All rights reserved.
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