Article
Chemistry, Medicinal
Koki Ishii, Sakura Tsuchitani, Miyu Toyama, Hajime Shigeto, Shohei Yamamura, Takashi Ohtsuki, Yoshitane Imai, Mizuki Kitamatsu
Summary: We developed a method for detecting DNA using excimer fluorescence from PNA-Pyr probes, and optimized the spatial arrangement for optimal excimer formation.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Analytical
Dheeraj Pandey, Kondakamarla Imran, Rajesh Kumar Yadav, Jasleen Kaur, Saba Naqvi, Abha Sharma
Summary: In this work, a solvatochromic fluorescent probe (MQM) was synthesized and evaluated for the rapid and selective detection of hydrazine in water samples, with a limit of detection of 0.58 μM. The most important application is that the probe can be transformed into a portable analytical tool for on-site detection of hydrazine without the use of sophisticated instruments. The probe can be applied for real-time detection of hydrazine in water, vapor phase, soil, and biological samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Lingyuan Xu, Xiuyuan Zhang, A. M. Abd El-Aty, Yuanshang Wang, Zhen Cao, Huiyan Jia, J. -Pablo Salvador, Ahmet Hacimuftuoglu, Xueyan Cui, Yudan Zhang, Kun Wang, Yongxin She, Fen Jin, Lufei Zheng, Baima Pujia, Jing Wang, Maojun Jin, Bruce D. Hammock
Summary: A highly sensitive fluorescence anti-quenching multi-residue bio-barcode immunoassay has been developed to detect organophosphate pesticides in fruits and vegetables. The method is stable, reliable, and able to detect low residual levels of organophosphate pesticides in agricultural products.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Attila Csomos, Ervin Kovacs, Miklos Madarasz, Flora Zsofia Fedor, Anna Fulop, Gergely Katona, Balazs Rozsa, Zoltan Mucsi
Summary: A library of fluorescent GFP chromophore based chemosensors (GFZnPs) was prepared for the detection of Zn2+ using two-photon microscopy. These sensors exhibit high selectivity, excellent water solubility, and wide pH-range usability, making them one of the best two-photon probes for Zn2+.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Physical
Christopher Schad, Edurne Avellanal-Zaballa, Esther Rebollar, Cesar Ray, Eduardo Duque-Redondo, Florencio Moreno, Beatriz L. Maroto, Jorge Banuelos, Inmaculada Garcia-Moreno, Santiago De la Moya
Summary: We proposed a new approach for achieving triplet-triplet annihilation-assisted photon upconversion by the rational design of an all-organic molecular assembly. This design takes advantage of the synthetic accessibility and chemical versatility of COO-BODIPY scaffold. Laser-induced photophysical characterization and computational simulations were used to understand and control the energy transfer efficiency between triplet states. Theoretical simulations also demonstrated the importance of the new photoactivable chromophoric design for enhancing photon upconversion.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Applied
Fang Hou, Xiaolei Liu, Xueying Hao, Guofei Li, Futai Lu, Qiliang Deng
Summary: Two new D-A-D structured organic dyes (LM1 and LM2) have been designed and synthesized for detecting water content in organic solvents. LM2, with a stronger electron-withdrawing acceptor, shows better detection performance and great potential for detecting trace amounts of water in organic solvents.
Article
Materials Science, Multidisciplinary
Mingguang Zhu, Shizhou Huang, Meihui Chen, Yangping Li, Min Zhong
Summary: In this study, a pair of Schiff's base conjugates were developed by modifying benzil hydrazone with 4-dimethylaminobenzaldehyde and 4-(diethylamino)salicylaldehyde. The 4-(diethylamino)salicylaldehyde-functionalized Schiff's base exhibited multicolor changes in different states and could be used as a probe for detecting Cu2+.
Article
Chemistry, Analytical
Chunwei Yu, Mei Yang, Shuhua Cui, Yuxiang Ji, Jun Zhang
Summary: A novel ratiometric Cu2+-selective probe was constructed based on pyrene derivative, which showed selective recognition and detection of Cu2+ through a turn-on fluorescent response. The formation of a 1:1 metal-ligand complex and the binding mode were confirmed by MS spectra, Job's plot experiment, and H-1 NMR experiment. Satisfactory results were obtained from fluorescence imaging in living cells for Cu2+ detection.
Article
Polymer Science
Tao Li, Yu-Jing Sheng, Xiao-Li Sun, Wen-Ming Wan, Yanru Liu, Qingrong Qian, Qinghua Chen
Summary: The isosteric replacement of CC by B-N units in conjugated organic systems has attracted significant interest due to its desirable optical, electronic and sensory properties. In this study, a series of polymers with BNB-doped pi-system were synthesized and investigated for their structure, photophysical properties and metal ion detection. The polymers exhibited solvatochromic fluorescence and showed potential as metal fluorescence sensors.
Article
Chemistry, Multidisciplinary
Aigui Zhang, Dasharath Kondhare, Peter Leonard, Frank Seela
Summary: This study explores the application of purine-2,6-diamine and its derivatives in isothermal DNA strand displacement reactions and introduces two new fluorescent sensors to monitor the progress of the reactions. The fluorescence intensity changes as the displacement reaction progresses. The findings demonstrate the potential of strand displacement with base pair stabilizers in various fields, including chemical biology, nanotechnology, and medicinal diagnostics.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Aigui Zhang, Dasharath Kondhare, Peter Leonard, Frank Seela
Summary: The study explores the molecular recognition of complementary purine and pyrimidine bases in the Watson-Crick coding system. Experimental results show that the introduction of specifically modified base pairs can alter the stability and global helical structure of double-stranded DNA. Introducing purine-purine base pairs can lead to novel molecular recognition patterns.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Imrich Geci, Maha Fatthalla, Maike Heintz, Per T. Jorgensen, Erik B. Pedersen
Summary: In this study, we synthesized a DNA intercalator called TINA and found that it can improve the binding ability of triplex DNA and duplex DNA. The introduction of TINA monomer Y can stabilize the oligodeoxynucleotide sequence, resulting in enhanced thermal stability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Miklos Nagy, Bela Fiser, Milan Szori, Laszlo Vanyorek, Bela Viskolcz
Summary: Isocyanoaminoarenes are a versatile group of fluorophores with potential applications in various fields. This paper presents the preparation and optical study of a novel isocyano derivative and its variations. The conversion of one amino group into an isocyano group greatly enhanced the polar character of the dyes, resulting in improved solvatochromism and reduced fluorescence in polar solvents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Bo Zhao, Qi Yang, Jia-Si Wang, Feng-Yang Xie, Hong-Yi Yu, Yue Li, Yu-Xin Ma, Wen-Juan Ruan
Summary: This study utilized pyrene-based MOFs for the analysis of paraquat, showing that the introduction of anionic ligands improved sensing performance, although the effectiveness of this improvement depended on the medium of analysis. Ultimately, detection of paraquat and achieving nM-scale detection limits were successfully demonstrated in this system.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Analytical
Youhui Zeng, Ruiying Peng, Yingcai Hu, Pan Luo, Ronghua Yang, Jishan Li, Jing Zheng
Summary: Spherical nucleic acids (SNAs) have been extensively utilized in molecular imaging and tumor therapy due to their adjustable hybridization activity, antinuclease digestion stability, and superior endocytosis. However, the challenge lies in the background signal caused by highly expressed biomarkers in tumors and the inability to precisely release probes at the chosen region. To address this issue, researchers have proposed an endogenous enzyme-activatable functional SNA (Ep-SNA) strategy for spatiotemporally controlled signal amplification molecular imaging and combinational tumor therapy.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Rajen Kundu
Article
Chemistry, Analytical
Smruti Ranjan Dash, Subhendu Sekhar, Animes Kumar Golder
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Biochemistry & Molecular Biology
Subhendu Sekhar Bag, Sayantan Sinha, Hiranya Gogoi, Subhashis Datta, Rajen Kundu, Sangita Talukdar
BIOPHYSICAL CHEMISTRY
(2020)
Review
Chemistry, Multidisciplinary
Rajen Kundu, Priyanka Payal
Article
Chemistry, Analytical
Smruti Ranjan Dash, Subhendu Sekhar Bag, Animes Kumar Golder
Summary: The study successfully prepared PtNPs/graphene nanocomposite for sensing of metabolites of dipyrone. The fabrication process was simple and showed good sensing performance. The nanocomposite exhibited stable sensing signals in different samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Materials Science, Composites
Subhendu Sekhar Bag, Anupama Bora, Animes Kr. Golder
Summary: A study has developed PS-AgNPs composites using green synthesized AgNPs and waste thermocol, showing antibacterial effects against Escherichia coli. The morphology of the nanocomposites was studied using FESEM and FETEM, while FTIR was used to evaluate surface chemical bonding and composition, and TGA for thermal properties.
POLYMER COMPOSITES
(2021)
Article
Energy & Fuels
Rajen Kundu, Suranjan De
Summary: Nuclear magnetic resonance (NMR) spectroscopy was used to study the triglyceride transesterification process and characterize the biodiesel waste products. Detailed NMR studies were performed to analyze the reaction mixture and products. The zero-waste valorization of biodiesel waste involves purification of low-value byproducts into high-value products and the utilization of fatty acids and esters for surfactant preparation. This approach contributes to resource management and sustainable development.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Biochemistry & Molecular Biology
Subhendu Sekhar Bag, Suranjan De, Shilpa Bhuyan
Summary: A novel intramolecular cyclization method was reported for the synthesis of unnatural thioxoimidazolidinyl/thioxooxazolidinyl amino acids. Interestingly, under similar reaction conditions, analogous isothiocyanyl amines either formed 5-membered thiourea or acyclic diethylaminyl thiourea derivative instead of the expected 6-membered cyclic thiourea.
Article
Gastroenterology & Hepatology
Satoshi Nojima, Shoichi Ishida, Kei Terayama, Katsuhiko Matsumoto, Takahiro Matsui, Shinichiro Tahara, Kenji Ohshima, Hiroki Kiyokawa, Kansuke Kido, Koto Ukon, Shota Y. Yoshida, Tomoki T. Mitani, Yuichiro Doki, Tsunekazu Mizushima, Yasushi Okuno, Etsuo A. Susaki, Hiroki R. Ueda, Eiichi Morii
Summary: This study developed a novel fluorescence staining method and a three-dimensional imaging system based on it, which enabled clear and detailed imaging of the three-dimensional architecture of crypts in human colorectal mucosa. The imaging method also identified abnormal changes in crypts and the distribution of neutrophils in inflammatory bowel diseases. Quantitative analysis of crypts based on three-dimensional morphologic changes allowed for differential diagnosis of ulcerative colitis, Crohn's disease, and non-inflammatory bowel disease, surpassing the capabilities of pathologists. Additionally, a deep learning-based system using the three-dimensional imaging could accurately distinguish these diseases.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Bappaditya Das, Rajen Kundu, Sanchita Chakravarty
Summary: A facile method for the preparation of graphene oxide from semi-bituminous coal was reported in this study, and the synthesized material was characterized by various techniques to confirm its graphene oxide properties.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Physical
Subhendu Sekhar Bag, Sayantan Sinha, Siddharth Singh, Animes K. K. Golder
Summary: We propose a unique nano-photocatalyst, [Cu-II@TiO2], for achieving hetero-selective Glaser coupling reaction in a green solvent. This photocatalyst demonstrates high efficiency, excellent turnover number, high yields, fast reaction kinetics, and good functional-group compatibility. By using photogenerated electrons and holes/O-2 in air, comprehensive temporal and spatial control over the hetero-Glaser coupling reaction is achieved.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Sneha Kumari, Toushali Roy, Saswati Chakladar, Alok Kumar, Md. Arif, Ashok Mohanty, Rajen Kundu, Sanchita Chakravarty
Summary: This study examines the distribution and concentration of REEs and major elements in coal samples from the Samaleswari coal block in Odisha, India. The coal ash samples were found to be rich in SiO2 and had lower proportions of Al2O3, Fe2O3, and TiO2. The average concentration of REEs in the four boreholes was 510 ppm, with the distribution pattern being Ce > La > Nd > Y > Pr > Sc > Sm > Gd > Dy > Er > Yb > Eu > Ho > Tb > Tm > Lu. The study concludes that the coal seams in this region are a promising source of REEs.
ENVIRONMENTAL EARTH SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Vikash Mahato, Sudip Kumar, Arindam Sen, Syed Md Burhan Ali, Chandan Ghanty, Rajen Kundu
Summary: As a potential cathode material, nanocrystalline LiNi0.5Mn0.5O2 was successfully synthesized and extensively characterized. It exhibited reversible capacity, low capacity fading, and moderate rate performance. The deterioration in electrochemical properties was mainly attributed to side reactions and the formation of SEI layer.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2023)
Review
Multidisciplinary Sciences
Douglas S. Richardson, Webster Guan, Katsuhiko Matsumoto, Chenchen Pan, Kwanghun Chung, Ali Erturk, Hiroki R. Ueda, Jeff W. Lichtman
Summary: Tissue clearing technology has widespread applications and potential in the field of microscopy. This article outlines a modular approach for researchers to develop clearing processes, and provides overviews of certain applications, technological limitations, and future development prospects.
NATURE REVIEWS METHODS PRIMERS
(2021)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
