期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 4, 页码 1436-1439出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.12.085
关键词
K(v)1.5; IKur; Atrial fibrillation; Potassium channel blocker
Design and synthesis of pyrazolodihydropyrimidines as K(V)1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development. (C) 2010 Elsevier Ltd. All rights reserved.
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