期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 1, 页码 132-136出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.11.015
关键词
Pyrazolines; MAO-inhibitors; Docking
Ten novel 3,5-diaryl pyrazolines were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. All the molecules were found to be reversible and selective inhibitor for either one of the isoform (MAO-A or MAO-B). Further insights in the theoretical evaluation of the possible interactions between the compounds and monoamine oxidases (MAO-A or MAO-B) have been developed through docking studies. The theoretical values are in congruence with their experimental values. (C) 2009 Elsevier Ltd. All rights reserved.
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