In vitro antitubercular and antimicrobial activities of 1-substituted quinoxaline-2,3(1H,4H)-diones

1-((Substituted) methyl) quinoxaline-2,3(1H,4H)-dione (2a-e) and 1-((substituted) acryloyl) quinoxaline-2,3(1H,4H)-dione (4a-c) were synthesized from quinoxaline-2,3(1H, 4H)-dione 1 and evaluated for their antimicrobial activities. Results of the antitubercular screening against Mycobacterium tuberculosis H(37)Rv showed that the compounds 2b, 3, and 4a were the most effective, with minimum inhibitory concentrations of 8.012, 8.561, and 8.928 mu g/ml, respectively. All the compounds exhibited significant antibacterial and considerable antifungal activities. (C) 2009 Elsevier Ltd. All rights reserved.