Article
Radiology, Nuclear Medicine & Medical Imaging
Isabell K. Bones, Suzanne L. Franklin, Anita A. Harteveld, Matthias J. P. van Osch, Sophie Schmid, Jeroen Hendrikse, Chrit Moonen, Marijn van Stralen, Clemens Bos
Summary: Velocity-selective arterial spin labeling in renal perfusion imaging shows advantages over spatially selective pulsed arterial spin labeling techniques, reducing arterial transit time sensitivity and potentially providing efficient and accurate measurements even when increasing cutoff velocity to reduce labeling errors caused by motion.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jia Guo, Shaurov Das, Luis Hernandez-Garcia
Summary: Among the velocity-selective (VS) labeling schemes, dual-sBIR8-VSS and sinc-VSI measured the highest SNR efficiency. Dual-sBIR8-VSS was the most robust against field imperfections, while sinc-VSI may provide a higher SNR efficiency if its immunity to field imperfections can be improved. Both were confirmed by phantom and in vivo data, with sinc-VSI pulses showing the highest temporal SNR due to partial background suppression effects.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Qin Qin, David C. Alsop, Divya S. Bolar, Luis Hernandez-Garcia, James Meakin, Dapeng Liu, Krishna S. Nayak, Sophie Schmid, Matthias J. P. van Osch, Eric C. Wong, Joseph G. Woods, Greg Zaharchuk, Moss Y. Zhao, Zungho Zun, Jia Guo
Summary: This review article provides an overview of the current status of velocity-selective arterial spin labeling (VSASL) perfusion MRI and discusses its concepts, implementation, clinical applications, and technical challenges.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne L. Franklin, Isabell K. Bones, Anita A. Harteveld, Lydiane Hirschler, Marijn van Stralen, Qin Qin, Anneloes de Boer, Johannes M. Hoogduin, Clemens Bos, Matthias J. P. van Osch, Sophie Schmid
Summary: Flow-based ASL techniques provide an alternative to spatially selective techniques with similar performance in the brain and comparable performance in the kidney, with VSI-ASL showing the most potential in brain imaging. Further improvements are needed in kidney imaging to match FAIR's performance.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dapeng Liu, Dan Zhu, Feng Xu, Farzad Sedaghat, Qin Qin
Summary: The purpose of this study was to develop velocity selective arterial spin labeling (VSASL) protocols for prostate blood flow (PBF) and prostate blood volume (PBV) mapping. Fourier-transform based velocity-selective inversion and saturation pulse trains were used to obtain blood flow and blood volume weighted perfusion signal in VSASL sequences. The study found that a low cutoff velocity of 0.25-0.50 cm/s was necessary for adequate perfusion signal in both PBF and PBV measurements in prostate.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
James H. Holmes, Mu-Lan Jen, Laura B. Eisenmenger, Tilman Schubert, Patrick A. Turski, Kevin M. Johnson
Summary: This study introduces a mapping approach to investigate the relative tagging efficiency of VS-ASL, validated through numerical simulations and experiments. Unique efficiency patterns were observed in normal volunteers based on individual anatomy and physiology. While uniform tagging efficiency was generally seen in vivo, regions of high blood velocity and local susceptibility gradients showed reduced efficiency.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jia Guo
Summary: A novel dual-module velocity-selective arterial spin labeling (dm-VSASL) strategy is developed to improve the signal-to-noise ratio (SNR) efficiency and the temporal SNR for robust, accurate, and delay-insensitive perfusion mapping.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sven Bambach, Mark Smith, P. Pearse Morris, Norbert G. Campeau, Mai-Lan Ho
Summary: Arterial spin labeling (ASL) is a noncontrast MRI technique used for quantitative evaluation of brain perfusion. This article discusses advanced applications of ASL across the lifespan, presenting case examples from children and adults with various pathologies. The article highlights the subtleties and pitfalls of ASL interpretation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuhei Shibukawa, Misaki Saito, Tetsu Niwa, Makoto Obara, Natsuo Konta, Takuya Hara, Takashi Okazaki, Takakiyo Nomura
Summary: The study optimized eAccASL for MRA of the hands by using low AENC values and found that venous contamination may increase with elevation of arterial blood flow. Hand temperature was not significantly correlated with image quality scores.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyuan Fan, Zhentao Zuo, Tianye Lin, Zhichao Lai, Hui You, Jianxun Qu, Juan Wei, Bao Liu, Feng Feng
Summary: The study aimed to investigate whether preoperative arterial spin labeling (ASL) MRI can predict cerebral hyperperfusion after carotid endarterectomy (CEA) in patients with carotid stenosis. The study found that ASL can non-invasively predict cerebral hyperperfusion after CEA in patients with carotid stenosis based on the presence of arterial transit artifacts (ATAs).
EUROPEAN RADIOLOGY
(2022)
Article
Psychiatry
J. M. Batail, I. Corouge, B. Combes, C. Conan, M. Guillery-Sollier, M. Verin, P. Sauleau, F. Le Jeune, J. Y. Gauvrit, G. Robert, C. Barillot, J. C. Ferre, D. Drapier
Summary: This study investigated the neurovascular mechanisms underlying apathy in depression using neuroimaging techniques. The results showed a negative correlation between cerebral blood flow in the left anterior cingulate cortex (ACC) and the severity of apathy, highlighting the significance of this region in depressed individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Lindner, Divya S. Bolar, Eric Achten, Frederik Barkhof, Antonio J. Bastos-Leite, John A. Detre, Xavier Golay, Matthias Guenther, Danny J. J. Wang, Sven Haller, Silvia Ingala, Hans R. Jaeger, Geon-Ho Jahng, Meher R. Juttukonda, Vera C. Keil, Hirohiko Kimura, Mai-Lan Ho, Maarten Lequin, Xin Lou, Jan Petr, Nandor Pinter, Francesca B. Pizzini, Marion Smits, Magdalena Sokolska, Greg Zaharchuk, Henk J. M. M. Mutsaerts
Summary: This article provides guidance on the clinical applications of arterial spin labeling (ASL) MRI, focusing on disease-specific considerations for sequence optimization and interpretation. It updates and expands on the recommendations from the 2015 ASL consensus paper, which lacked guidance on disease-specific parameters. The article covers various clinical scenarios, including acute ischemic stroke, brain tumors, and pediatric neuroradiology applications.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yaoming Qu, Dexia Kong, Haitao Wen, Xiaochan Ou, Qihong Rui, Xianlong Wang, Doris D. Lin, Qin Qin, Zhibo Wen
Summary: The performance of velocity-selective (VS) ASL was evaluated in patients with untreated gliomas, compared with both pseudo-continuous (PC) ASL and dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI). VSASL showed comparable results with DSC-PWI in visual inspection and yielded higher correlation with DSC-PWI in quantitative analysis compared to PCASL. VSASL also showed superior diagnostic sensitivity, specificity, and accuracy in glioma grading compared to PCASL.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zongqiong Sun, Shudong Hu, Yuxi Ge, Linfang Jin, Jianfeng Huang, Weiqiang Dou
Summary: The study demonstrated that ASL perfusion imaging showed high diagnostic efficiency in differentiating between NPC and NPL, improving the accuracy of diagnosing malignancies in the nasopharynx.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Medicine, General & Internal
Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study investigated the effects of dobutamine on cerebral hemodynamics and found that dobutamine stress significantly decreased cerebral blood flow in the frontal lobe anterior circulation. Additionally, body mass index, resting systolic blood pressure, and basilar artery diameter were significantly associated with changes in frontal lobe cerebral blood flow.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivar J. H. G. Wamelink, Joost P. A. Kuijer, Beatriz E. Padrela, Yi Zhang, Frederik Barkhof, Henk J. M. M. Mutsaerts, Jan Petr, Elsmarieke van de Giessen, Vera C. Keil
Summary: This study investigates the reproducibility of cerebral APT-CEST imaging in healthy tissue and gliomas at 3 T. The results indicate that cerebral APT-CEST shows good scan-rescan reproducibility in healthy tissue and tumors, and short-term measurement effects may be the dominant components for reproducibility.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Endocrinology & Metabolism
Khazar Ahmadi, Joana B. Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T. Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk J. M. M. Mutsaerts, Oskar Hansson
Summary: This study investigated the role of decreased cerebral blood flow in Alzheimer's disease and found that tau tangles and neurodegeneration are more closely connected with GM-CBF changes than A beta pathology.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne L. L. Franklin, Megan Schuurmans, Martins Otikovs, Pim T. S. Borman, Matthias J. P. van Osch, Clemens Bos
Summary: This study evaluated the feasibility and robustness of using SPEN readout for pCASL imaging in the brain, and its resistance to susceptibility artifacts caused by aneurysm clips. The results showed that SPEN with Q greater than 75 can provide better resistance to field inhomogeneity compared to SE-EPI and GE-EPI, and the clip-induced artifact with SPEN was smaller.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Lindner, Divya S. Bolar, Eric Achten, Frederik Barkhof, Antonio J. Bastos-Leite, John A. Detre, Xavier Golay, Matthias Guenther, Danny J. J. Wang, Sven Haller, Silvia Ingala, Hans R. Jaeger, Geon-Ho Jahng, Meher R. Juttukonda, Vera C. Keil, Hirohiko Kimura, Mai-Lan Ho, Maarten Lequin, Xin Lou, Jan Petr, Nandor Pinter, Francesca B. Pizzini, Marion Smits, Magdalena Sokolska, Greg Zaharchuk, Henk J. M. M. Mutsaerts
Summary: This article provides guidance on the clinical applications of arterial spin labeling (ASL) MRI, focusing on disease-specific considerations for sequence optimization and interpretation. It updates and expands on the recommendations from the 2015 ASL consensus paper, which lacked guidance on disease-specific parameters. The article covers various clinical scenarios, including acute ischemic stroke, brain tumors, and pediatric neuroradiology applications.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Debby Vreeken, Florine Seidel, Guido de la Roij, Wouter Vening, Willem A. A. den Hengst, Lars Verschuren, Serdar oezsezen, Roy P. C. Kessels, Marco Duering, Henk J. M. M. Mutsaerts, Robert Kleemann, Maximilian Wiesmann, Eric J. J. Hazebroek, Amanda J. J. Kiliaan
Summary: This study investigated the association between omental white adipose tissue (oWAT) and subcutaneous white adipose tissue (scWAT) with brain structure, perfusion, and cognition in adults with severe obesity. The study found that oWAT morphology is significantly related to cerebrovascular health in obesity, while scWAT is not associated with brain readouts.
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Review
Geriatrics & Gerontology
Paulien Moyaert, Beatriz E. Padrela, Catherine A. Morgan, Jan Petr, Jan Versijpt, Frederik Barkhof, Michael T. Jurkiewicz, Xingfeng Shao, Olujide Oyeniran, Tabitha Manson, Danny J. J. Wang, Matthias Guenther, Eric Achten, Henk J. M. M. Mutsaerts, Udunna C. Anazodo
Summary: The blood-brain barrier (BBB) plays a crucial role in protecting the brain's microenvironment, and dysfunction of BBB could lead to neuroinflammatory events and neuronal degeneration. BBB imaging has the potential to be an early diagnostic and prognostic biomarker for neurological diseases. However, further advances are needed in terms of validation, standardization, and implementation of affordable and non-contrast BBB imaging techniques.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biology
Irene Cumplido-Mayoral, Marina Garcia-Prat, Gregory Operto, Carles Falcon, Mahnaz Shekari, Raffaele Cacciaglia, Marta Mila-Aloma, Luigi Lorenzini, Silvia Ingala, Alle Meije Wink, Henk J. M. M. Mutsaerts, Carolina Minguillon, Karine Fauria, Jose Luis Molinuevo, Sven Haller, Gael Chetelat, Adam Waldman, Adam J. Schwarz, Frederik Barkhof, Ivonne Suridjan, Gwendlyn Kollmorgen, Anna Bayfield, Henrik Zetterberg, Kaj Blennow, Marc Suarez-Calvet, Veronica Vilaplana, Juan Domingo Gispert
Summary: Brain--age can be used as a marker of biological brain aging by comparing it with chronological age, and accelerated aging is found in neurodegenerative disorders like Alzheimer's disease. This study validates brain--age delta as a non-invasive marker of biological brain aging in cognitively unimpaired individuals with abnormal levels of biomarkers of AD and axonal injury. The study also found associations between brain--age delta and abnormal amyloid-ss, advanced stages of AD pathology, APOE-e4 status, and plasma neurofilament light.
Review
Physiology
Pien E. J. Jellema, Jannie P. Wijnen, Alberto De Luca, Henk J. M. M. Mutsaerts, Iris V. Obdeijn, Kirsten M. van Baarsen, Maarten H. Lequin, Eelco W. Hoving
Summary: This review aims to determine the added value of advanced imaging in intraoperative MRI for pediatric brain tumor surgery compared to conventional imaging. The use of advanced MRI sequences could provide additional physiological information and aid in the preservation of healthy brain regions.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
L. Malin Overmars, Sanne Kuipers, Bram van Es, Jeroen de Bresser, Esther E. Bron, Imo E. Hoefer, Wouter W. Van Solinge, L. Jaap Kappelle, Matthias J. P. van Osch, Charlotte E. Teunissen, Geert Jan Biessels, Saskia Haitjema
Summary: The biological processes causing decreased cerebral blood flow in cardiovascular disease patients are not well understood. Identifying protein clusters associated with lower cerebral blood flow may provide insight into these underlying processes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiming Dong, Kirsten Koolstra, Ziyu Li, Malte Riedel, Matthias J. P. van Osch, Peter Boernert
Summary: The proposed algorithm effectively eliminates shot-to-shot phase variations and separates water/fat images, providing a promising solution for future DWI on different anatomies.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biophysics
Chih-Hsien Tseng, Jaap Jaspers, Alejandra Mendez Romero, Piotr Wielopolski, Marion Smits, Matthias J. P. van Osch, Frans Vos
Summary: The arterial input function (AIF) is crucial for estimating perfusion properties from dynamic susceptibility contrast (DSC) MRI. Measuring the AIF in absolute contrast-agent concentrations is challenging, but deriving the AIF from separately acquired dynamic contrast enhanced (DCE) MRI data is a potential solution. This study compared the AIFs derived from DCE and DSC MRI data and found that the DCE-based AIFs provided more stable and realistic measurements of perfusion coefficients.
NMR IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Luigi Lorenzini, Silvia Ingala, Lyduine E. Collij, Viktor Wottschel, Sven Haller, Kaj Blennow, Giovanni Frisoni, Gael Chetelat, Pierre Payoux, Pablo Lage-Martinez, Michael Ewers, Adam Waldman, Joanna Wardlaw, Craig Ritchie, Juan Domingo Gispert, Henk J. M. M. Mutsaerts, Pieter Jelle Visser, Philip Scheltens, Betty Tijms, Frederik Barkhof, Alle Meije Wink
Summary: Amyloid-beta accumulation in highly connected brain regions is associated with functional connectivity alterations in the early stages of Alzheimer's disease. Dynamic functional connectivity variations indicate increased regional flexibility and promote functional integration. This study investigates the associations between abnormal cerebrospinal fluid amyloid and static and dynamic properties of functional hubs, and their relationship with cognitive performance in non-demented participants. The results suggest that dynamic eigenvector centrality is an early biomarker of Alzheimer's disease pathology and cognitive decline.
BRAIN COMMUNICATIONS
(2023)
Review
Clinical Neurology
Janine Hendriks, Henk-Jan Mutsaerts, Richard Joules, Oscar Pena-Nogales, Paulo R. Rodrigues, Robin Wolz, George L. Burchell, Frederik Barkhof, Anouk Schrantee
Summary: This systematic review provides an overview of the available (semi-)automatic QC algorithms and software packages for raw, structural T1-weighted (T1w) MRI datasets, and analyzes the differences among these algorithms in terms of their features, performance, and benchmarks.
Article
Oncology
Barbara Schmitz-Abecassis, Linda Dirven, Janey Jiang, Jasmin A. Keller, Robert J. Croese, Danielle van Dorth, Rashid Ghaznawi, Ilse M. J. Kant, Martin J. B. Taphoorn, Matthias J. P. van Osch, Johan A. F. Koekkoek, Jeroen de Bresser
Summary: This study establishes different MRI phenotypes of glioblastomas at 3 months after radiotherapy through combined analysis of structural and perfusion tumor characteristics, and finds that one of the phenotypes is significantly associated with increased mortality risk.
NEURO-ONCOLOGY ADVANCES
(2023)