期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 9, 页码 2868-2871出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.03.024
关键词
A(2A) Antagonist; A(1) Antagonist; Adenosine antagonists; Parkinson's disease; Mouse catalepsy; Dopamine
Two reactive metabolites were identified in vivo for the dual A(2A)/A(1) receptor antagonist 1. Two strategies were implemented to successfully mitigate the metabolic liabilities associated with 1. Optimization of the arylindenopyrimidines led to a number of amide, ether, and amino analogs having comparable in vitro and in vivo activity. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据