期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 5, 页码 1626-1629出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.01.028
关键词
2 ',4 '-Bridged nucleoside-5 '-triphosphate; Bridged nucleic acid (BNA); Nuclease resistance; Post-modification; Terminal deoxynucleotidyl transferase (TdT)
资金
- Japan Society for the Promotion of Science (JSPS)
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
The capping of the 3'-ends of thrombin binding aptamers (TBAs) with bridged nucleotides increased the nuclease resistances and the stabilities in human serum. The binding abilities of the aptamers were not affected by the capping. The capping could be simply executed via a one step enzymatic process using 2',4'-bridged nucleoside 5'-triphosphate and terminal deoxynucleotidyl transferase. (C) 2010 Elsevier Ltd. All rights reserved.
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