期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 14, 页码 4128-4131出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.05.067
关键词
Myristica fragrans; Myristicaceae; Tetrahydrofuran lignans; AMP-activated protein kinase (AMPK)
资金
- Ministry for Health, Welfare & Family Affairs, Republic of Korea [A084335]
- National Research Foundation of Korea (NRF) [RO1-2008-000-20253-0]
- Ministry of Education, Science and Technology (MEST)
AMP-activated protein kinase (AMPK) is a potential therapeutic target for the treatment of metabolic syndrome including obesity and type-2 diabetes. As part of an ongoing search for new AMPK activators from plants, this study found that the total extract of Myristica fragrans (nutmeg) activated the AMPK enzyme in differentiated C2C12 cells. As active constituents, seven 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignans, tetrahydrofuroguaiacin B (1), saucernetindiol (2), verrucosin (3), nectandrin B (4), nectandrin A (5), fragransin C(1) (6), and galbacin (7) were isolated from this extract. Among the isolates, compounds 1, 4, and 5 at 5 mu M produced strong AMPK stimulation in differentiated C2C12 cells. In addition, the preventive effect of a tetrahydrofuran mixture (THF) on weight gain in a diet-induced animal model was further examined. These results suggest that nutmeg and its active constituents can be used not only for the development of agents to treat obesity and possibly type-2 diabetes but may also be bene. cial for other metabolic disorders. (C) 2010 Elsevier Ltd. All rights reserved.
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