期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 1, 页码 222-227出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.10.134
关键词
Selective serotonin reuptake inhibitors; Central nervous system; Antidepressant; 5-HT1A antagonist; Lactam-fused chroman amine derivatives
The structure-activity relationship (SAR) for three series of lactam-fused chroman derivatives possessing 3-amino substituents was evaluated. Many compounds exhibited affinities for both the 5-HT1A receptor and the 5-HT transporter. Compounds 45 and 53 demonstrated 5-HT1A antagonist activities in the in vitro cAMP turnover model. (C) 2009 Elsevier Ltd. All rights reserved.
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