New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists

Synthesis and structure-activity relationship studies on a new aminopropandiol class of derivatives as calcium-sensing receptor antagonists are described. Modification of the phenolic moiety of a calcilytic compound NPS 2143 led to the identification of an orally available compound (R,R)-31 which demonstrated a rapid and transient stimulation of PTH release in rats. (C) 2010 Elsevier Ltd. All rights reserved.