期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 21, 页码 6200-6204出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.08.095
关键词
LuxS; Quorum sensing; Biofilm; Autoinducer; AI-2; Halogenated furanone; Brominated furanone; Enzyme inhibition; Natural products; Covalent modification
资金
- NIAID
- NIH [1R01AI058146, R01EB003872]
- College of Sciences
- Washington State University
Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2). (c) 2009 Elsevier Ltd. All rights reserved.
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