Article
Chemistry, Organic
Carson Lawrence Hasselbrink, Josephine Bridget Shirah, Samantha Renee Sylvain, Brenton DeBoef
Summary: The synthesis of Noria macrocycle derivatives and structurally similar macrocycle R3 derivatives, each containing 12 sulfonic acid groups, is reported. We demonstrate their utility as reusable Brinsted acid catalysts in the Biginelli synthesis and Pechmann synthesis. The supramolecular structure directs the reagents to interact with the sulfonic acid catalytic sites, thus increasing the efficiency of the catalyst.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra K. Gladysz, Jan Stepniak, Malgorzata Karbownik-Lewinska
Summary: The study aimed to investigate the potential protective effects of known antioxidants, such as melatonin and indole-3-propionic acid (IPA), against the oxidative damage caused by sodium/iodide symporter (NIS) inhibitors. Melatonin was found to prevent oxidative damage to membrane lipids in the thyroid caused by certain NIS inhibitors.
Article
Chemistry, Physical
Madhu Deepan Kumar, Madhavan Jaccob
Summary: This study utilized density functional theory calculations to investigate the impact of four choline-based ionic liquids on the tautomeric equilibrium of ethyl acetoacetate. The results showed that explicit involvement of the cationic and anionic parts of the ionic liquids significantly reduces the activation free energy barrier.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Review
Biochemistry & Molecular Biology
M. Krishna Prasad, Sundhar Mohandas, Ramkumar Kunka Mohanram
Summary: Ferroptosis is involved in the pathogenesis of diabetes, leading to beta-cell death and insulin resistance. Ferroptosis inhibitors show promise in alleviating diabetes and its complications.
Review
Medicine, Research & Experimental
Tian-Liang Ma, Jing-Xian Chen, Peng Zhu, Chao-Bin Zhang, Yong Zhou, Jia-Xi Duan
Summary: Ferroptosis is an iron-dependent regulatory necrosis characterized by the accumulation of iron-dependent lipid peroxides in the plasma membrane and subsequent oxidative damage. It is mainly related to iron toxicity, lipid peroxidation, and mitochondrial dysfunction. Understanding the specific mechanism of ferroptosis and exploring strategies for its regulation have significant clinical implications.
Article
Biochemistry & Molecular Biology
Jan Stepniak, Aleksandra Rynkowska, Malgorzata Karbownik-Lewinska
Summary: Iron is essential for many organs but its overload can be toxic. Excessive iron absorption and deposition can lead to diseases like hemochromatosis. This study found that the thyroid is less sensitive to oxidative effects caused by Fenton reaction substrates and melatonin has the same protective effects in different tissues.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Polymer Science
Fangdong Zhang, Yandong Tang, Xiaoli Yang, Yufan Pan, Qingxi Hou, Yumei Ding, Jicheng Pei
Summary: In this study, carboxylated chitosan oligosaccharide (C-COS) was prepared by selectively oxidizing chitosan oligosaccharide (COS) and its inhibitory effects on lipid peroxidation were evaluated in vitro. The results showed that C-COS exhibited better inhibition effects than COS, which was mainly attributed to the chelation of carboxylic acid groups on C6 with metal ions, reducing the generation of free radicals. Additionally, exposing more amino sites outside the sugar chain promoted the capture of free radicals, effectively preventing lipid peroxidation.
Editorial Material
Oncology
Jose Pedro Friedmann Angeli, Thamara Nishida Xavier da Silva, Bastian Schilling
Summary: In this study, Liao et al. show that CD8(+) T cell-secreted IFN-γ rewires cancer cell lipid metabolism via ACSL4, activating polyunsaturated fatty acids and sensitizing cancer cells to ferroptosis in immunotherapy-relevant settings.
Article
Biochemistry & Molecular Biology
Yajing You, Chenxi Liu, Tiantian Liu, Miaomiao Tian, Nijin Wu, Zhen Yu, Fenglin Zhao, Jianni Qi, Qiang Zhu
Summary: This study reveals the crucial role of FNDC3B in protecting against hepatic steatosis and ferroptosis in response to chronic alcohol consumption. Our findings suggest that FNDC3B could be a potential therapeutic target for ALD.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Raul Arcusa, Juan Angel Carillo, Begona Cerda, Thierry Durand, Angel Gil-Izquierdo, Sonia Medina, Jean-Marie Galano, Maria Pilar Zafrilla, Javier Marhuenda
Summary: This study aimed to evaluate the efficacy of long-term consumption of high polyphenolic content from fruits and vegetables (such as berries) as a nutraceutical against central nervous system lipid peroxidation, as assessed through urine biomarkers. The results showed significant reductions in AdA and DHA-derived metabolites after consumption of the nutraceutical, indicating its effectiveness in preventing CNS lipid peroxidation.
Article
Chemistry, Multidisciplinary
Nima Moeini, Abdolali Alemi, Zolfaghar Rezvani
Summary: Spinel metal ferrite nanoparticles (MFe2O4) have attracted significant research interest due to their unique physical and chemical properties. In this study, efficient and low-cost CuFe2-xYxO4 nanoparticles with different compositions (x: 0.00, 0.25, 0.50, 0.75, and 1.00) were designed, synthesized, and applied as catalysts for click and pechmann reactions. The resulting nanomaterial exhibited improved catalytic properties due to the uniform distribution of yttrium and copper ions in its structure. The nanocatalyst showed high catalytic efficiency for triazole derivatives (82-97%) and coumarin derivatives (88-97%), and it could be reused without significant decrease in catalytic activity.
Article
Chemistry, Multidisciplinary
Esmail Rezaei-Seresht, Fatemeh Tafazzoli Gazkoh, Behrooz Maleki
Summary: This work describes the synthesis and characterization of a heterogeneous catalyst consisting of piperazine-functionalized reduced graphene oxide decorated with Fe3O4 nanoparticles. The catalyst showed great catalytic activity for Pechmann synthesis of coumarins, and its reusability was also studied. The results indicate that the catalyst is efficient, easy to separate, and can be used for multiple reactions.
Article
Biochemistry & Molecular Biology
Yang Liu, Yuan Wang, Zhi Lin, Rui Kang, Daolin Tang, Jiao Liu
Summary: SLC25A22 acts as a metabolic repressor of ferroptosis by producing glutathione and monounsaturated fatty acids, providing a previously unrecognized defense pathway against ferroptotic cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Azza A. A. Attia, Jehan M. M. Sorour, Neama A. A. Mohamed, Tagreed T. T. Mansour, Rasha A. A. Al-Eisa, Nahla S. S. El-Shenawy
Summary: This study aimed to investigate the protective role of vitamin E in improving cardiotoxicity induced by cyclophosphamide in rats. The results showed that vitamin E could attenuate the elevation of cardiac markers, increase in lipid profiles, reduction in antioxidant enzyme activities, and increase in lipid peroxidation. In addition, vitamin E was found to improve the histopathological alterations caused by cyclophosphamide.
Article
Chemistry, Multidisciplinary
A. R. Ortiz Moreno, R. Li, K. Wu, R. Schirhagl
Summary: Lipid peroxidation is a process where reactive oxygen species attack lipids within cell membranes, leading to toxic and carcinogenic products. Understanding this process at nanoscale resolution is important and challenging due to the short lifespan and reactivity of the radical intermediates involved. In this study, lipid peroxidation of three artificial lipid bilayers on a diamond substrate was investigated using a diamond quantum sensing method called T-1-relaxometry, allowing for in situ measurements and imaging of radical intermediates.
Article
Chemistry, Medicinal
Michael G. Kallitsakis, Matilde Yanez, Elena Soriano, Jose Marco-Contelles, Dimitra J. Hadjipavlou-Litina, Konstantinos E. Litinas
FUTURE MEDICINAL CHEMISTRY
(2015)
Article
Chemistry, Applied
Michael Kallitsakis, Edward Loukopoulos, Alaa Abdul-Sada, Graham J. Tizzard, Simon J. Coles, George E. Kostakis, Ioannis N. Lykakis
ADVANCED SYNTHESIS & CATALYSIS
(2017)
Article
Chemistry, Inorganic & Nuclear
Edward Loukopoulos, Michael Kallitsakis, Nikolaos Tsoureas, Alaa Abdul-Sada, Nicholas F. Chilton, Ioannis N. Lykakis, George E. Kostakis
INORGANIC CHEMISTRY
(2017)
Article
Chemistry, Organic
Michael G. Kallitsakis, Peter D. Tancini, Mudit Dixit, Giannis Mpourmpakis, Ioannis N. Lykakis
JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Organic
Dimitrios Andreou, Michael G. Kallitsakis, Edward Loukopoulos, Catherine Gabriel, George E. Kostakis, Ioannis N. Lykakis
JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Michael G. Kallitsakis, Dimitra J. Hadjipavlou-Litina, Konstantinos E. Litinas
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Organic
Theodoros S. Symeonidis, Michael G. Kallitsakis, Konstantinos E. Litinas
TETRAHEDRON LETTERS
(2011)
Correction
Chemistry, Organic
Theodoros S. Symeonidis, Michael G. Kallitsakis, Konstantinos E. Litinas
TETRAHEDRON LETTERS
(2013)
Article
Chemistry, Organic
Michael G. Kallitsakis, Dimitra J. Hadjipavlou-Litina, Aikaterini Peperidou, Konstantinos E. Litinas
TETRAHEDRON LETTERS
(2014)
Article
Chemistry, Multidisciplinary
Marina A. Tzani, Michael G. Kallitsakis, Theodoros S. Symeonidis, Ioannis N. Lykakis
Article
Chemistry, Applied
Evangelia Charistoudi, Michael G. Kallitsakis, Ioannis Charisteidis, Kostas S. Triantafyllidis, Ioannis N. Lykakis
ADVANCED SYNTHESIS & CATALYSIS
(2017)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)