期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 18, 页码 5325-5328出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.07.131
关键词
Pyrazole; Carboxamide; A549 cells; Apoptosis; Autophagy
资金
- National Natural Science Foundation of China [90813022]
- Science and Technology Developmental Project of Shandong Province [2008GG10002034]
A series of novel 3-aryl-1-arylmethyl-1H-pyrazole-5-carboxamide derivatives 3a-1, were synthesized by the reaction of 3-aryl-1-arylmethyl-1H-pyrazole-5-carbonyl chloride with substituted amine in excellent yields. The compounds 3e-h could suppress A549 lung cancer cell growth, More interestingly, compounds 3e and 3f might inhibit the A549 cell growth by inducing apoptosis; whereas compounds 3g and 3h with fluorine group might inhibit the A549 cell growth by inducing autophagy. (C) 2009 Elsevier Ltd. All rights reserved.
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