Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening

A novel series of isatin-based inhibitors of beta-secretase (BACE-1) have been identified using a virtual high-throughput screening approach. Structure-activity relationship studies revealed structural features important for inhibition. Docking studies suggest these inhibitors may bind within the BACE-1 active site through H-bonding interactions involving the catalytic aspartate residues. (C) 2009 Elsevier Ltd. All rights reserved.