Article
Chemistry, Multidisciplinary
Kelsey R. Miller, Saborni Biswas, Andrew Jasniewski, Alec H. Follmer, Ankita Biswas, Therese Albert, Sinan Sabuncu, Emile L. Bominaar, Michael P. Hendrich, Pierre Moenne-Loccoz, A. S. Borovik
Summary: The research focuses on designing artificial proteins to achieve active sites with entatic states by simulating a controlled environment. Utilizing biotin-streptavidin technology, artificial di-Fe cores containing Fe centers have been successfully assembled, revealing the process of Fe center separation regulation by the protein host.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Nadir Jori, Megan Keener, Thayalan Rajeshkumar, Rosario Scopelliti, Laurent Maron, Marinella Mazzanti
Summary: Understanding the importance of multimetallic cooperativity and alkali ion-binding in the second coordination sphere is crucial for the design of complexes that can facilitate the cleavage and functionalization of dinitrogen (N-2) molecules. In this study, the reaction products and mechanism of N-2 reduction were compared for different uranium(III) complexes with and without alkali ion binding. It was found that the removal of alkali ions enhanced the reducing ability of the complex and led to the formation of new species. Furthermore, the formation of a tetranuclear uranium-N-2 intermediate was proposed, demonstrating the possibility of a three-electron transfer from U(III) to N-2.
Article
Chemistry, Physical
Amirreza Valizadeh, Rahman Bikas, Pavlo Aleshkevych, Anna Kozakiewicz, Suleyman I. Allakhverdiev, Mohammad Mahdi Najafpour
Summary: Water oxidation is a key reaction for water splitting, and the decomposition of Fe-based-molecular structures toward Fe-based oxides shows promise for the oxygen-evolution reaction (OER) through water oxidation. The study investigates the Fe species formed through the decomposition of a dinuclear Fe(III) complex under OER using various analytical methods. A new approach using Ni(OH)2 to detect trace Fe species on the electrode surface is reported, and the resulting Fe oxide-based catalyst exhibits efficient catalytic activity under specific conditions.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Chemistry, Inorganic & Nuclear
A. J. Brock, I. M. Etchells, E. G. Moore, J. K. Clegg
Summary: The synthesis and crystal structures of a series of Ln(iii) complexes incorporating a bis-beta-diketone ligand with a 1,3-substituted phenyl ring were reported. The complexes were found to be seven coordinate in the solid state. The photophysical properties of the complexes in both solution and solid state showed an increase in coordination number in solution.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Didar Asik, Samira M. Abozeid, Steven G. Turowski, Joseph A. Spernyak, Janet R. Morrow
Summary: Four high-spin Fe(III) macrocyclic complexes were synthesized for potential applications as iron-based MRI contrast agents, with dinuclear complexes showing significantly increased relaxivity compared to mononuclear counterparts at appropriate field strengths.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yoshinori Okayasu, Takuya Miyahara, Rintaro Shimada, Yuki Nagai, Akira Sakamoto, Jiro Abe, Yoichi Kobayashi
Summary: We find that the phenoxyl-imidazolyl radical complex (PIC) can serve as a ligand to directly coordinate with iridium (iii) ions. The resulting iridium complexes exhibit photochromic reactions characteristic of the PIC moiety, although the behavior of transient species differs significantly from that of the PIC.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Qingqing Wen, Thayalan Rajeshkumar, Laurent Maron, Xuebing Leng, Yaofeng Chen
Summary: The first rare-earth metal complex bearing both hydrido- and imido-ligands, a hydrido- and imido-bridged dinuclear ytterbium(III) complex, was successfully synthesized via an unprecedented redox reaction. DFT calculation revealed that the N-2 release from azido compound in the presence of ytterbium(II) is kinetically facile due to cooperative effects. The reactivity investigation of the complex demonstrated redox, addition, and sigma-bond metathesis reactivities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Cleverton O. C. da Silveira, Samuel H. M. Santos, Tamyris T. da Cunha, Willian X. C. Oliveira, Kariny C. V. Nolasco, Walace D. do Pim, Adriele A. de Almeida, Marcelo Knobel, Carlos B. Pinheiro, Joao C. D. Figueiredo-Junior, Luiz C. A. Oliveira, Emerson F. Pedroso, Cynthia L. M. Pereira
Summary: In this study, a new air-stable oxo-bridged diiron(III) complex was synthesized for the first time, and its magnetic properties were confirmed through experimentation.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Zhongxian Fan, Yi Rong, Tumpa Sadhukhan, Shaoxia Liang, Wenqing Li, Zhanxiang Yuan, Zilin Zhu, Shunwen Guo, Shaomin Ji, Jinquan Wang, Rajesh Kushwaha, Samya Banerjee, Krishnan Raghavachari, Huaiyi Huang
Summary: The uptake and retention of Ir-III photoredox catalysts were studied in single cancer cells using single-cell inductively coupled plasma mass spectrometry. The dinuclear catalyst showed significant synergism and high photocatalytic therapeutic efficiency.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Ryusei Hoshikawa, Kosuke Yoshida, Ryoji Mitsuhashi, Masahiro Mikuriya, Takashi Okuno, Hiroshi Sakiyama
Summary: The structures and symmetry of oxido-bridged dinuclear iron(III) complexes vary depending on the circumstances and intramolecular interligand interactions. The Fe-O-Fe bridge tends to bend like a water molecule but can be stretched by interligand steric repulsion. Overall, these structures are mainly controlled by intramolecular interligand interactions.
Article
Polymer Science
Anum Hayat, Mohammad Saeed Iqbal, Naveed Ahmad, Nabil K. Alruwaili, Atta Ur Rehman
Summary: An iron (III) complex with rhamnoxylan, a hemicellulose from Salvia plebeia seeds, was synthesized and exhibited good electrical and magnetic properties. In addition, the complex showed equivalent efficacy as a hematinic for treating iron deficiency anemia in a rabbit model compared to iron protein succinylate. Therefore, iron(III)-rhamnoxylan holds potential as a hematinic for treatment of iron deficiency anemia.
Article
Multidisciplinary Sciences
Yingzhuang Xu, Songyi Li, Huayi Fang
Summary: This article reports the synthesis of a rare coplanar dinuclear hydroxycarbonylcobalt(III) complex and demonstrates that the Co - carboxylate bonds can be easily cleaved, leading to the formation of oxalic acid. The authors also achieved the direct production of oxalic acid from CO and H2O using this complex as a catalyst, with high selectivity and atom economy.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Niklas Biere, Dennis Kreft, Volker Walhorn, Sabrina Schwarzbich, Thorsten Glaser, Dario Anselmetti
Summary: Dinuclear copper complexes have been designed to selectively bind to neighboring phosphate moieties in DNA. Previous works have investigated the effects of these complexes on DNA through biophysical, biochemical, and cytotoxic analyses, with atomic force microscopy (AFM) being particularly valuable in assessing the macroscopic properties of the DNA strands. To gain a deeper understanding of these effects, cutting-edge preparation methods and scanning force microscopy under ultra-high vacuum (UHV) conditions were used to obtain submolecular resolution images. The mechanics and interactions of the DNA strands were analyzed at the single base pair level, including the formation of melting bubbles and the interaction of individual complex molecules.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuichi Kitagawa, Kenji Matsuda, Pedro Paulo Ferreira da Rosa, Koji Fushimi, Yasuchika Hasegawa
Summary: A long-lived near-infrared Nd(iii) emission at 1057 nm is demonstrated using Tb(iii) as the donor, with an emission lifetime of 290 µs attributed to the appropriate spacing between the Tb(iii) donor and the Nd(iii) acceptor, leading to novel lanthanide photophysics.
CHEMICAL COMMUNICATIONS
(2021)
Article
Physics, Applied
Sai Wang, Denghui Liu, Xiugang Wu, Li Wang, Jingwei Huang, Jun Chen, Yafei Wang, Weiguo Zhu
Summary: This study utilized a TADF host and low-concentration dinuclear platinum (III) complex to construct high-performance WOLEDs with high efficiency, CRI, CCT, and color stability.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)