期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 11, 页码 3036-3040出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.020
关键词
Aristolactam; Sauristolactam; Piperolactam; Cepharanone; Anticancer; Cytotoxicity; Phenanthrene lactam
资金
- Korea Research Institute of Chemical Technology [SI-0905]
- National Research Council of Science & Technology (NST), Republic of Korea [SI-0905] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A series of natural aristolactams and their analogues have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam showed moderate antitumor activities in selected cell lines. However, several synthetic aristolactam derivatives exhibited potent antitumor activities against a broad array of cancer cell lines with GI(50) values in the submicromolar range. (C) 2009 Elsevier Ltd. All rights reserved.
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