Review
Biochemistry & Molecular Biology
Amir H. Sharif, Mohammed Iqbal, Bahareh Manhoosh, Negin Gholampoor, Dan Ma, Mandeep Marwah, Lissette Sanchez-Aranguren
Summary: CNS-related conditions are a major cause of disability globally and are associated with inflammation and impaired oxidative response. Hydrogen sulphide (H2S) has a neuroprotective role and therapeutic approaches targeting its mechanisms have been explored. Defects in H2S metabolism have been identified in CNS-related disorders, but restoring H2S availability using H2S-donating compounds has shown promise in several models. However, more research is needed to understand their implications and improve delivery to CNS tissues.
NEUROCHEMICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Joon-Mo Kim, Kyung-Rim Sung, Hwang-Ki Kim, Sang-Woo Park, Eun-Ji Lee, Jin-Wook Jeoung, Hae-Young Lopilly Park, Jaehong Ahn, Chungkwon Yoo, Chan-Yun Kim
Summary: This multicenter retrospective cohort study compared the effectiveness and safety of long-term tafluprost, travoprost, or latanoprost in patients with primary open-angle glaucoma (POAG) or normal-tension glaucoma (NTG). The study found that all three prostaglandin analogs showed similar effects in patients with POAG or NTG, with good long-term safety profiles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Physical
Mohamed Khairy, Khaled G. Mahmoud
Summary: This research achieved the in-situ synthesis of nanostructured nickel sulphides through hydrothermal treatment of nickel foam, resulting in efficient water electrolyzers. The nickel sulphide nanoneedles exhibited excellent performance in the oxygen evolution reaction, while the sheet-like morphology showed low overpotential in the hydrogen evolution reaction. Integrating these materials with water electrolyzers offers a low-cost, sustainable, and scalable overall water splitting system.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Dermatology
Ling Li, Xudong Chen, Chang Liu, Ziying He, Qiyan Shen, Yue Zhu, Xin Wang, Shuanglin Cao, Shengju Yang
Summary: This study investigated the roles and mechanisms of hydrogen sulphide (H2S) on primary mice skin fibroblasts proliferation. The study found that H2S can inhibit the proliferation of skin fibroblasts and attenuate skin fibrosis by inhibiting necroptosis. These findings provide new insights into the prevention and treatment of skin fibrotic diseases.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Plant Sciences
A. K. Choudhary, S. Singh, N. Khatri, R. Gupta
Summary: Hydrogen sulphide, as a gaseous signalling molecule in plants, has potential roles in plant defence against invading pathogens through various mechanisms, such as modulating enzyme activity and inducing expression of defence-related genes.
Article
Chemistry, Physical
Murthy Muniyappa, Sagara N. Kalegowda, Manjunath Shetty, Jagadeesh Babu Sriramoju, Mahesh Shastri, Navakoteswara S. Rao, Debasis De, M. Shankar, Dinesh Rangappa
Summary: Metal chalcogenides are promising materials for photocatalytic hydrogen evolution. In this study, cocatalyst-free nickel sulfides with different nanostructures were synthesized and characterized. The synthesized nickel sulfides showed good photocatalytic activity for hydrogen generation under UV-Vis light irradiation.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Agronomy
Haitao Yu, Liuli Song, Jingjing Han, Xiaoyu Yu, Yuzhen Wu, Zhifang Yu
Summary: This study found that H2S treatment can delay the senescence process of postharvest pakchoi by regulating antioxidant system, endogenous H2S and NO metabolism. H2S increased the activities of antioxidant enzymes by up-regulating the expression of enzyme genes, reducing the accumulation of harmful substances. Furthermore, H2S increased the content of cysteine and nitrate in pakchoi by regulating the expression of related genes and enzyme activities, thus slowing down the senescence of pakchoi.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2024)
Article
Multidisciplinary Sciences
Yuanyuan Yao, Wenjie Kan, Pengfei Su, Yan Zhu, Wenling Zhong, Jinfeng Xi, Dacheng Wang, Caiguo Tang, Lifang Wu
Summary: This study first reported that hydrogen sulphide (H2S) can significantly alleviate the symptoms of FHB in wheat caused by F. graminearum. H2S enhances FHB resistance by reducing oxidative stress and upregulating defence-related gene expression. In addition, H2S exhibits toxic effects on F. graminearum, inhibiting its growth and spore germination.
Article
Pharmacology & Pharmacy
Katarzyna Asendrych-Wicik, Jakub Zarczuk, Katarzyna Walaszek, Tomasz Ciach, Magdalena Markowicz-Piasecka
Summary: The ocular delivery route poses challenges in terms of drug administration and bioavailability. This review focuses on the analysis and quality assessment of glaucoma treatments. Impurity profiling and stability-indicating analytical methods are important for assessing the quality of PGF2 alpha analogues. The development of more specific and accurate methods is crucial for determining content and related substances.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Jonas da Silva de Sa, Rafael da Silva Gama, Jose Antonio da Cunha Ponciano Gomes
Summary: The study found that seamless 9% Ni steel tubes experienced greater ductility loss at open circuit potential (OCP) compared to cathodic potential, with the difference attributed to the inhibition of anodic dissolution at cathodic potential. The fracture surface exhibited mixed morphology, with ductile morphology in the center and brittle morphology near the edges.
CORROSION ENGINEERING SCIENCE AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lin Zhou, Wenyi Zhan, Xin Wei
Summary: Glaucoma is a leading cause of irreversible visual loss globally. Prostaglandin analogs are considered the most effective treatment and 0.03% bimatoprost shows the best long-term efficacy. Latanoprost has lower prevalence of adverse events compared to other analogs. Genetic factors contribute to the individual's response to prostaglandin analogs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sonia Nasi, Driss Ehirchiou, Jessica Bertrand, Mariela Castelblanco, James Mitchell, Isao Ishii, Alexander So, Nathalie Busso
Summary: Pathologic calcification is a painful and disabling condition with poorly understood treatment options. Research suggests a crucial role of hydrogen sulfide and CSE in regulating PC in cartilage. Deficiency of CSE exacerbates cartilage calcification, while overexpression has a protective effect.
Article
Chemistry, Physical
Artem S. Mokrushin, Tatiana L. Simonenko, Nikolay P. Simonenko, Philipp Yu Gorobtsov, Nail C. Kadyrov, Elizaveta P. Simonenko, Vladimir G. Sevastyanov, Nikolay T. Kuznetsov
Summary: The Nb2O5 powder obtained by programmable precipitation was used to form a thick gas-sensing film for a chemoresistive gas sensor, demonstrating high sensitivity to oxygen and hydrogen sulphide at low detection temperatures. The influence of humidity on the detection of oxygen and hydrogen sulphide was studied, showing a decrease in resistance and response value at high humidity levels, with different impacts on the two gases' detection signals.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Physical
Nurul Noramelya Zulkefli, Adam Mohd Izhan Noor Azam, Mohd Shahbudin Masdar, Wan Nor Roslam Wan Isahak
Summary: Metal-based adsorbents with varying active phase loadings were synthesized for H2S capture. The adsorption performance was evaluated and modified adsorbents showed the highest adsorption capacity. The behavioral model for H2S adsorption-desorption was validated effectively and the adsorbents' capability at the highest number of adsorption-desorption cycles was demonstrated.
Article
Materials Science, Multidisciplinary
Pengpeng Bai, Shaowei Li, Jie Cheng, Xiangli Wen, Shuqi Zheng, Changfeng Chen, Yu Tian
Summary: Hexagonal Fe-S compounds show different barrier effects on hydrogen permeation, with mackinawite having no obvious barrier effect and pyrrhotite (including troilite) exhibiting significant barrier effect. The peak permeation performance was observed with a continuous film of pyrrhotite and troilite. The suppression of hydrogen permeation by FeS compounds is attributed to the promotion of hydrogen evolution reaction, semiconducting inversion from p- to n-type, and ion migration at the interface.
INTERNATIONAL JOURNAL OF MINERALS METALLURGY AND MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Niccolo Lombardi, Giada Crescioli, Valentina Maggini, Ilaria Ippoliti, Francesca Menniti-Ippolito, Eugenia Gallo, Valentina Brilli, Cecilia Lanzi, Guido Mannaioni, Fabio Firenzuoli, Alfredo Vannacci
Summary: Several cases of acute non-infectious cholestatic hepatitis in Italy were linked to the consumption of Curcuma longa-containing dietary supplements. Analysis of Tuscan cases revealed a strong association between hepatotoxicity and Curcuma longa formulations with high bioavailability and dosage. A systematic review of the literature further confirmed this association, with the majority of patients having positive dechallenge outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Editorial Material
Behavioral Sciences
Maenia Scarpino, Manuela Bonizzoli, Cecilia Lanzi, Giovanni Lanzo, Chiara Lazzeri, Giovanni Cianchi, Francesco Gambassi, Francesco Lolli, Antonello Grippo
BRAIN AND BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Homira Rezai, Shakil Ahmad, Faisal A. Alzahrani, Lissette Sanchez-Aranguren, Irundika H. K. Dias, Swati Agrawal, Anna Sparatore, Keqing Wang, Asif Ahmed
Summary: Preeclampsia is a common and serious complication affecting millions of pregnant women worldwide. This study found that a novel H2S-releasing aspirin can ameliorate preeclampsia by reducing hypertension and renal damage through possibly stimulating antioxidant genes, improving fetal outcomes compared to aspirin alone.
Article
Medicine, General & Internal
Giada Crescioli, Valentina Brilli, Cecilia Lanzi, Andrea Burgalassi, Alessandra Ieri, Roberto Bonaiuti, Elias Romano, Rinaldo Innocenti, Guido Mannaioni, Alfredo Vannacci, Niccolo Lombardi
Summary: This study aimed to describe the clinical and pharmacological characteristics of SARS-CoV-2 hospitalized patients, focusing on ADRs, particularly those related to drug-drug interactions (DDIs). Among the 23 Caucasian patients during the study period, most were exposed to polypharmacy, and 17.4% had comorbidities. ADRs mainly involved cardiovascular, psychiatric, and gastrointestinal disorders, with a high incidence of QT prolongation. ADRs improved or resolved completely in 60.8% of cases.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gian Marco Tosi, Daniela Giustarini, Lorenzo Franci, Alberto Minetti, Francesco Imperatore, Elena Caldi, Paolo Fiorenzani, Anna Maria Aloisi, Anna Sparatore, Ranieri Rossi, Mario Chiariello, Maurizio Orlandini, Federico Galvagni
Summary: Oxidative stress is crucial in the pathophysiology of retinal diseases, with NACET showing potential as a more efficient alternative to NAC in preventing and treating AMD, by increasing intracellular GSH levels and enhancing oxidative stress resistance in RPE cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jaimy Saif, Shakil Ahmad, Homira Rezai, Karina Litvinova, Anna Sparatore, Faisal A. Alzahrani, Keqing Wang, Asif Ahmed
Summary: An imbalanced angiogenic growth factors and poor utero-placental perfusion are strongly correlated with preeclampsia. A refined RUPP model in C57B1/6 J mice was developed to test the efficacy of MZe786 as a potential inhibitor of soluble Flt-1 for preeclampsia therapy. The study demonstrated that MZe786 treatment successfully prevented the development of preeclampsia by reducing maternal MAP and kidney nitrotyrosine staining, and improving fetal outcomes.
Article
Biochemistry & Molecular Biology
Ivan Bassanini, Silvia Parapini, Erica E. Ferrandi, Elena Gabriele, Nicoletta Basilico, Donatella Taramelli, Anna Sparatore
Summary: The study utilized the natural triterpene celastrol as a lead compound for designing and synthesizing a panel of eleven CE carboxamides, which were tested in vitro for their growth inhibitory activity against Leishmania parasites. Four of these compounds showed nanomolar leishmanicidal activity and low toxicity towards human and murine cell lines. The most selective CE analogue also inhibited the ATPase activity of Leishmania protein chaperone Hsp90, suggesting potential for future biochemical investigations.
Letter
Medicine, General & Internal
Giada Crescioli, Cecilia Lanzi, Guido Mannaioni, Alfredo Vannacci, Niccolo Lombardi
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Toxicology
Andrea Missanelli, Niccolo Lombardi, Alessandra Bettiol, Cecilia Lanzi, Francesco Rossi, Ilaria Pacileo, Lucia Donvito, Valentina Garofalo, Claudia Ravaldi, Alfredo Vannacci, Guido Mannaioni, Alessandra Pistelli
Summary: The study confirms that exposure to radio-diagnostic procedures in the first trimester of pregnancy at doses below 100 mSv does not increase the risk of embryo-fetal toxicity. Folic acid plays a protective role in preventing adverse pregnancy outcomes. Further research is needed to explore the relationship between maternal thyroid irradiation and small for gestational age infants.
CLINICAL TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Giada Crescioli, Cecilia Lanzi, Francesco Gambassi, Alessandra Ieri, Anita Ercolini, Giulia Borgioli, Alessandra Bettiol, Alfredo Vannacci, Guido Mannaioni, Niccolo Lombardi
Summary: During the SARS-CoV-2 pandemic, data on cleaner and disinfectant exposure-related intoxications in Italy were analyzed. The majority of cases involved patients of all age groups, with most events occurring at home due to domestic accidents. Misuse of these products may have been influenced by home isolation and unintentional exposure to toxic agents.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Silvia Sgambellone, Laura Lucarini, Cecilia Lanzi, Emanuela Masini
Summary: Glaucoma is a neurodegenerative disease characterized by increased intraocular pressure (IOP), with histamine being a potential neuromodulatory target for future treatments. The progressive degeneration of retinal ganglionic cells (RGCs) in glaucoma is influenced by factors like IOP fluctuations, making histamine and its receptors significant in understanding and potentially treating the condition.
Article
Pharmacology & Pharmacy
Silvia Marino, Nicole Hannemann, Ryan T. Bishop, Feier Zeng, Giovana Carrasco, Sandrine Meurisse, Boya Li, Antonia Sophocleous, Anna Sparatore, Tobias Baeuerle, Slobodan Vukicevic, Marielle Auberval, Patrick Mollat, Aline Bozec, Aymen I. Idris
Summary: TRAF6 inhibitors may be beneficial in managing the inflammatory component of bone disorders, but they may not provide protection against local or systemic bone loss unless combined with anti-resorptive therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Alexey Koval, Ivan Bassanini, Jiabin Xu, Michele Tonelli, Vito Boido, Fabio Sparatore, Frederic Amant, Daniela Annibali, Eleonora Leucci, Anna Sparatore, Vladimir L. Katanaev
Summary: Clofazimine has been optimized to enhance its potency as a Wnt inhibitor, with MU17 identified as a more potent lead compound for targeted therapy against TNBC and Wnt-dependent cancers. MU17 displayed a 7-fold improved potency against Wnt signaling in TNBC cells and showed no adverse effects, particularly no clofazimine-related skin coloration.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Francesco Gambassi, Cecilia Lanzi, Zaccaria Ricci, Pierpaolo Duchini, Manuela L'Erario, Guido Mannaioni, Nicoletta Cini, Alessandro Bonari, Claudia Saffirio, Brunella Occupati
Summary: This article reports the first case of toad egg poisoning in Europe. The patient, a child with autism spectrum disorder, developed severe bradycardia after ingesting a large quantity of toad eggs in a mountain creek. The administration of antidotal therapy successfully treated the cardiac toxicity caused by bufadienolides.
Article
Biochemistry & Molecular Biology
Nicoletta Basilico, Silvia Parapini, Sarah D'Alessandro, Paola Misiano, Sergio Romeo, Giulio Dondio, Vanessa Yardley, Livia Vivas, Shereen Nasser, Laurent Renia, Bruce M. Russell, Rossarin Suwanarusk, Francois Nosten, Anna Sparatore, Donatella Taramelli
Summary: The novel pyrrolizidinylmethyl derivative MG3 showed excellent antimalarial activity against drug-resistant parasites, both in vitro and in vivo. The compound exhibited comparable or better efficacy than chloroquine and other quinolines in rodent models of malaria, and its pharmacological profile met the requirements for further development.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
