期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 18, 页码 5372-5375出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.07.126
关键词
Anti-tuberculosis; 12-Diamine; SQ109
Guided by the metabolism information of SQ109, derivatives with substituted geranylamine moiety or substituted admantane ring of SQ109 were synthesized and evaluated as antituberculosis agents. Among all tested compounds, compound 11c showed the most potent antituberculosis activity with MIC value of 0.3 mu M against Mycobacterium tuberculosis H37Rv. (C) 2009 Elsevier Ltd. All rights reserved.
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