期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 10, 页码 2722-2727出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.118
关键词
SARS-CoV; Protease inhibitors; Drug design; Synthesis
资金
- Frontier Research Program
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Japan Society for the Promotion of Science's Post-Doctoral Fellowship
- National Institutes of Health [GM 57144]
A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Three candidates had encouraging results for the development of new anti-SARS compounds. (C) 2009 Elsevier Ltd. All rights reserved.
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