期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 14, 页码 3932-3933出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.065
关键词
GABA; Neurotransmitter; Caged compound; Synthesis
资金
- NSF [CHE 7904825, PGM 8018643]
- NIH [RR02002, GM 04842]
A short and convergent synthetic approach to new photoactivatable precursors of gamma-aminobutyric acid (GABA) is described. When photolyzed, the 'caged' GABA precursor efficiently releases GABA, as judged by depolarization measurements on the mammalian GABA(A) receptor. (C) 2009 Elsevier Ltd. All rights reserved.
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