期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 4, 页码 1511-1514出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.12.052
关键词
Siegesbeckia glabrescens; nitric oxide synthase; peroxynitrite
Four flavones, 3,4'- O- dimethylquercetin (1), 3,7- O- dimethylquercetin (2), 3- O- methylquercetin (3) and 3,7,4'- O- trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (IC50 values: 11.1, 4.2, 3.8, and 25.1 mu M, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC50 values of 1.75 and 0.77 mu M, respectively. (C) 2007 Elsevier Ltd. All rights reserved.
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