Article
Chemistry, Multidisciplinary
Sha Li, Yahan Sun, Xiaofang Li, Oskar Smaga, Sebastian Koniarz, Marcin Stepien, Piotr J. Chmielewski
Summary: A 1,3-cycloaddition reaction between 2-(tert-butyl)-8H-isoquinolino[4,3,2-de]phenanthridin-9-ium chloride and Ni-II norcorrole in the presence of base has been demonstrated to yield a family of chiral derivatives fused with pyrrole subunits of the macrocycle. Dehydrogenation of the cycloaddition products leads to dibenzoullazine ortho-fused antiaromatic porphyrinoids.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Kelvin J. Y. Wu, Amy E. Benedetto, Andrew G. Myers
Summary: The regioselectivity of a [3+2] dipolar cycloaddition reaction between a stabilized azomethine ylide and an electron-deficient dipolarophile is contrary to a previous report in this journal.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mohammed F. F. Radwan, Elghareeb E. E. Elboray, Hemat M. M. Dardeer, Yusuke Kobayashi, Takumi Furuta, Shohei Hamada, Toshifumi Dohi, Moustafa F. F. Aly
Summary: 1,3-Dipolar cycloaddition through in situ generation of azomethine ylide provides a straightforward and critically important sustainable approach for access to diverse pyrrolidine chemical space. Metal-free AcOH-activated 1,3-dipolar cycloaddition protocol was developed to synthesize uncommon pyrrolidine cycloadducts with excellent diastereoselectivity. The reaction mechanism and the key role of AcOH were supported by experimental, theoretical and spectroscopic studies.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Organic
Asmaa Belabbes, Veronica Selva, Francisco Foubelo, M. De Gracia Retamosa, Jose M. Sansano
Summary: The synthesis of complex spiro{pyrrolidine-3,1'-pyrrolo[3,4-c]pyrrole} skeleton under mild conditions is presented, with the order of addition of a primary amine and two equivalents of corresponding maleimide being crucial for high yields. The mechanism was studied by simple tests, revealing the Michael type addition of the amine onto the maleimide as a key step. Interesting scaffold hybrids were prepared through sequential addition of two different maleimides, and a more intriguing architecture was obtained through a metathesis reaction between allylic residues in the molecule precursor.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Hooi Xian Lee, Wai Ming Li, Chee Wei Ang, Kerry Reimer, Victor Liu, Brian O. Patrick, Keng Yoon Yeong, Chow H. Lee
Summary: A facile three components (3 + 2) cycloaddition of two novel dispiropyrrolizidines was achieved, leading to unprecedented regioselectivity. The structures and activities of the synthesized compounds were determined through experimental techniques and structural analysis methods. The compounds exhibited the ability to down-regulate KRAS expression in human colorectal cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Mariana Varde, Carla Marino, Evangelina Repetto, Oscar Varela
Summary: This study investigates the 1,3-dipolar cycloadditions starting from azomethine ylides and enantiomerically pure sugar-derived dihydropyranones. The reaction shows high regio- and diastereoselectivity under silver catalysis, resulting in the formation of pyrrolidine compounds with specific configurations.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Subarna Jyoti Kalita, Zhen-Ni Zhao, Zi-Han Li, Feng Cheng, Yan Zhao, Yi-Yong Huang
Summary: Experimental and theoretical studies have investigated the 1,3-dipolar cycloaddition of alpha-fluoro-alpha, beta-unsaturated arylketones and azomethine ylides. The reaction proceeds in a diastereodivergent fashion, with the endo-selective pathway achieved using an Ag(I) catalyst. Theoretical DFT calculations suggest that the coordination between the silver atom and the carbonyl oxygen atom of the enone drives the endo-selectivity.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Fatemeh Rostami Miankooshki, Mohammad Bayat, Shima Nasri, Narges Habibi Samet
Summary: This paper highlights the recent developments in the synthesis of spirooxindoles, focusing on representative synthetic methods and relevant reaction mechanisms from 2018 to 2021. It categorizes the synthetic methodologies based on the formation of azomethine ylide species from different starting materials.
MOLECULAR DIVERSITY
(2023)
Review
Chemistry, Organic
Liu Huachao, Shen Chong, Chang Xin, Wang Chunjiang
Summary: Kinetic resolution is an important strategy in asymmetric organic synthesis, which converts racemic compounds into highly optically active building blocks. However, in practice, kinetic resolution processes often have poor resolution efficiency and limited substrate scope. Recent developments in chiral ligands and catalysts have enabled the efficient separation of racemic substrates using the kinetic resolution strategy, resulting in versatile chiral molecules with excellent optical purity.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Sundaravel Vivek Kumar, Patrick J. Guiry
Summary: Asymmetric [3+2] cycloaddition reactions are interesting methods for synthesizing enantioenriched pyrrolidines with up to four stereocentres. Pyrrolidines are important compounds in biology and organocatalytic applications. This review summarizes the recent advancements in the enantioselective synthesis of pyrrolidines using metal catalysis, focusing on the [3+2] cycloadditions of azomethine ylides. The reactions are organized based on the type of metal catalysis and the complexity of the dipolarophile, highlighting their advantages and limitations.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shohei Furuya, Kazuya Kanemoto, Shin-ichi Fukuzawa
Summary: This study describes an unprecedented Ag-catalyzed exo'-selective [3+2] cycloaddition reaction between imino esters and 4-benzylidene-2,3-dioxopyrrolidines. The reaction, efficiently catalyzed by Ag/(R, S-p)-ThioClickFerrophos (TCF), allows for the construction of spirobipyrrolidine scaffolds with excellent enantio- and diastereoselectivities. It is the first example of a silver-catalyzed exo'-selective asymmetric [3+2] cycloaddition and the first exo'-selective spirobipyrrolidine construction process using imino esters. The broad substrate scope of this reaction enables the synthesis of diverse spirobipyrrolidine derivatives, which are of interest for drug discovery. Mechanistic studies suggest that the unusual exo'-selectivity of this reaction is due to a stepwise Michael addition/Mannich sequence with bond rotation, rather than epimerization following the common exo- or endo-selective cycloaddition.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Guosheng Yang, Sicheng Li, Qiumi Wang, Huabao Chen, Chunping Yang, Zhongqiong Yin, Xu Song, Li Zhang, Cuifen Lu, Guizhou Yue
Summary: The synthesis of dicyclic spiropyridazine oxoindole derivatives by [3+3]-cycloaddition reaction of N-unsubstituted isatin N,N'-cyclic azomethine imine 1,3-dipoles was successfully achieved. The products, having two consecutive stereocenters including spiroquaternary stereocenters in one ring structure, were obtained in moderate to excellent yields (20-93%) and low to moderate diastereoselectivities (1:9-10:1 dr). The synthesized compounds were thoroughly characterized using various spectroscopic techniques.
Article
Biochemistry & Molecular Biology
Guipeng Feng, Guoyang Ma, Wenyan Chen, Shaohong Xu, Kaikai Wang, Shaoyan Wang
Summary: The [3 + 2] 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines with allyl alkyl ketones has been achieved, resulting in a range of tetrahydroisoquinoline derivatives with good diastereoselectivities and enantioselectivities. The absolute configuration of the product was determined using quantum electronic circular dichroism calculation and ECD spectrum method.
Article
Biochemistry & Molecular Biology
Richa Sharma, Lalit Yadav, Ali Adnan Nasim, Ravi Kant Yadav, Rui Hong Chen, Neha Kumari, Fan Ruiqi, Ashoke Sharon, Nawal Kishore Sahu, Sirish Kumar Ippagunta, Paolo Coghi, Vincent Kam Wai Wong, Sandeep Chaudhary
Summary: A series of spirooxindoles based on nitrostyrene were synthesized and shown to have promising in vitro anticancer activity against human lung and liver cancer cell lines.
Article
Chemistry, Applied
Shiyong Peng, Hong Zhang, Yuqi Zhu, Ting Zhou, Jieyin He, Nuan Chen, Ming Lang, Hongguang Li, Jian Wang
Summary: A copper-catalyzed tandem reaction was reported for the synthesis of oxapolycyclic frameworks via intermolecular ylide formation and intramolecular cycloaddition, providing moderate to excellent yields under mild conditions. The reaction creates two C-C bonds and one C-O bond, with five stereocentres including two all-carbon quaternary centres. Late-stage diversification of products can be achieved through chemoselective substitutions.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Materials Science, Multidisciplinary
Bhavana Joshi, Edmund Samuel, Yong-il Kim, Govindasami Periyasami, Mostafizur Rahaman, Sam S. Yoon
Summary: Carbon nanofibers loaded with bimetallic hollow nanocage structures were synthesized and evaluated as anode materials for lithium-ion batteries. The composite anodes exhibited higher capacity and long-term stability, making them promising materials for use in portable LIBs.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Review
Chemistry, Physical
Jimmy Nelson Appaturi, Rajabathar. Jothi Ramalingam, Muthu Kumaran Gnanamani, Govindasami Periyasami, Prabhakarn Arunachalam, Rohana Adnan, Farook Adam, Mohammed D. Wasmiah, Hamad A. Al-Lohedan
Summary: The review article focuses on the role of ionic liquid-modified hybrid materials in cycloaddition reactions, with a special emphasis on the synthesis of cyclic carbonates. Factors such as reaction temperature and CO2 partial pressure are found to play a key role in cyclic carbonate formation. Solvent effect is also discussed as an influential parameter in the conversion of cyclic/aromatic oxides to polycarbonates.
Article
Polymer Science
Mostafizur Rahaman, Govindasami Periyasami, Ali Aldalbahi
Summary: This study investigates the effect of different gamma doses on pre- and post-alpha-irradiated PM-355 polymer, analyzing its phase crystallinity, structure, and optical properties using X-ray diffraction, scanning electron microscopy, and UV-VIS spectroscopy. The results show that irradiation and etching decrease crystallinity but increase crystallite and cluster size of the polymer. The optical band gap energy decreases with higher irradiation doses, indicating formation of nonradiative centers, with etched samples showing more significant changes in carbon atom per cluster and cluster size than nonetched ones. Photoluminescence analysis reveals induced defects and clusters in the polymer after irradiation, suggesting its potential use as a gamma radiation detector.
INTERNATIONAL JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Physical
Sani Ibrahim, R. Sanmugapriya, J. Arockia Selvi, T. Pushpa Malini, P. Kamaraj, P. A. Vivekanand, Govindasami Periyasami, Ali Aldalbahi, Karthikeyan Perumal, J. Madhavan, Santosh Khanal
Summary: In this study, the inhibition effect of 3-nitroacetophenone (3-NA) on the corrosion of mild steel in acidic medium was investigated. The results showed that 3-NA exhibited significant inhibition efficiency, reaching a maximum of 64% at a concentration of 250 ppm. The analysis also revealed that 3-NA acted as a mixed interdict and adsorbed onto the metal surface following the Langmuir adsorption isotherm.
INTERNATIONAL JOURNAL OF PHOTOENERGY
(2022)
Article
Nanoscience & Nanotechnology
Govindasami Periyasami, Selvakumar Palaniappan, Ponmurugan Karuppiah, Mostafizur Rahaman, Perumal Karthikeyan, Ali Aldalbahi, Naif Abdullah Al-Dhabi
Summary: The extract of Euphorbia granulata can be used to reduce silver ions to silver nanoparticles. These nanoparticles have antimicrobial and photocatalytic activity, and show potential as anticancer agents.
JOURNAL OF NANOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Paramasivam Sumathi, Navaneethan Renuka, Ramasamy Subramanian, Govindasami Periyasami, Mostafizur Rahaman, Perumal Karthikeyan
Summary: In this research, zirconia nanoflakes (ZrNFs) with a size of 8-15 nm were fabricated using Enicostemma littorale plant extract. The physiochemical properties of the synthesized ZrNFs were characterized, and the slower rate of electron transfer in the cellular interaction process was observed. The biocompatibility of the ZrNFs was evaluated on A431 human cancer cells, showing efficient toxicity.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Materials Science, Paper & Wood
Ashwin Khadka, Byeong-Yeop Kim, Shrayas Pradhan, Chanwoo Park, Woojin Lim, Ali Aldalbahi, Govindasami Periyasami, Bhavana Joshi, Sam S. S. Yoon
Summary: In this study, traditional Korean Hanji paper was coated with silver nanowires (AgNWs) via supersonic spraying and followed by electroplating with nickel to create a silver-nickel (AgNW-Ni) core-shell nanostructure for thermal protection. The AgNW-Ni Hanji paper heater showed stable long-term performance at a surface temperature of 125°C under 7V. The metal-metal core-shell nanostructure could be applied to various substrates and demonstrated mechanical durability and thermal stability.
Article
Chemistry, Physical
Mostafizur Rahaman, Prashant Gupta, Mokarram Hossain, Govindasami Periyasami, Paramita Das
Summary: The AC electrical properties of EVA- and NBR-based composites filled with different conductive fillers were investigated. The addition of these conductive fillers led to significant increases in AC electrical conductivity and dielectric permittivity, indicating their potential as supercapacitors. Different sigmoidal models were tested to determine the percolation threshold value of permittivity for these binary polymer composite systems, showing variation in results. The paper discusses the advantages, disadvantages, and limitations of these models, and compares them with classical percolation theory and results from published literature.
COLLOID AND POLYMER SCIENCE
(2023)
Article
Mechanics
Ashwin Khadka, Byeong-Yeop Kim, Chanwoo Park, Woojin Lim, Ali Aldalbahi, Govindasami Periyasami, Bhavana Joshi, Sam S. Yoon
Summary: Korean traditional Han paper (Hanji) is introduced as a substrate for nontransparent wearable heaters, offering eco-friendly cellulose fibers and high flexibility for low-cost production. Graphene flakes embedded in the fibrous structure of Hanji enhance its mechanical durability and enable high-temperature applications, making it suitable for thermotherapy.
Article
Energy & Fuels
Devi Prashad Ojha, Bhavana Joshi, Edmund Samuel, Ashwin Khadka, Ali Aldalbahi, Govindasami Periyasami, Daekyu Choi, Seongpil An, Sam S. Yoon
Summary: A flexible piezoelectric nanogenerator (PENG) was developed using crystalline zinc oxide (ZnO) microrods and polyvinylidene fluoride (PVDF) composite film. The PENG produced an output voltage of 15.2 V and current of 32 μA under a tapping force of 20 N at 5 Hz, with a maximum power density of 12.5 μW cm(-2). The flexibility and durability of the PENG were demonstrated by investigating the output voltage considering various body movements. Additionally, the supercapacitive properties of ZnO/reduced graphene oxide were studied.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2023)
Article
Chemistry, Physical
V. Ratchagar, M. Muralidharan, M. Silambarasan, K. Jagannathan, P. Kamaraj, Suresh Kumar Subbiah, P. A. Vivekanand, Govindasami Periyasami, Mostafizur Rahaman, Perumal Karthikeyan, Girma Gonfa
Summary: The cobalt oxide (Co3O4) nanomaterials were synthesized through coprecipitation technique with pH values of 7, 8, and 9. The resulting nanomaterials exhibited ligand-metal coordination and showed emission peaks at 488 nm and 745 nm in the photoluminescence spectra. Vibrating sample magnetometry confirmed the magnetic nature of the samples. Fourier transform infrared (FT-IR) spectrum revealed absorption bands at 584 cm(-1) and 666 cm(-1), corresponding to Co-O and O-Co-O stretching modes, respectively. The SEM image demonstrated a morphological transformation of the Co3O4 nanomaterials from spherical to cubic to agglomerated shape with increasing pH. UV-Vis spectra showed absorption bands at 473 nm and 762 nm for materials prepared at pH 7 and 8, while at pH 9, the peaks shifted to higher wavelengths at 515 nm and 777 nm. The cyclic voltammetry curves indicated good charge propagation with the electrodes. The Nyquist plots exhibited a semicircle in the high frequency region and a vertical line in the low frequency region. These findings suggest that Co3O4 is a promising material for applications in light-emitting diodes, solar cells, and optoelectronic devices.
INTERNATIONAL JOURNAL OF PHOTOENERGY
(2023)
Article
Materials Science, Multidisciplinary
Woojin Lim, Ashwin Khadka, Byeong-Yeop Kim, Chanwoo Park, Ali Aldalbahi, Govindasami Periyasami, Bhavana Joshi, Sam S. Yoon
Summary: Traditional Korean Hanji paper and cotton fabric were used as flexible substrates for fabricating graphene-coated heaters. Silver nanowires and PEDOT:PSS were added to enhance the electrical conductivity and heating performance. The optimal concentrations were identified and deposited using supersonic spraying. The proposed Hanji and cotton-based heaters were light, wearable, stretchable, skin-friendly, and biodegradable. The alumina-based heater exhibited the highest heating temperature and the supersonic spraying technique allowed for writable and patternable heaters.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Banat Gul, Muhammad Salman Khan, Bashir Ahmad, Govindasami Periyasami, Mostafizur Rahaman, Hijaz Ahmad
Summary: The optoelectronic and transport properties of Ba2GeX4 (X = S, and Se) materials were investigated using first-principles calculations. These materials exhibit a strong covalent nature and large band gaps, with major contributions from Ge-s states and minor contributions from Ge-p states. Significant absorption in the UV region suggests a weak transparent nature. The thermoelectric parameters indicate that these materials are suitable for thermoelectric applications.
JOURNAL OF SOLID STATE CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
M. Senthilkumar, P. Manisankar, R. Pandimurugan, P. A. Vivekanand, Govindasami Periyasami, S. Harikumar, Perumal Karthikeyan, Mostafizur Rahaman, Santosh Khanal
Summary: Substituted pyrazolyl derivatives were synthesized by Suzuki cross coupling of aromatic boronic acid with heterocyclic halide using newly synthesized nano-Pd/chitosan catalyst. The reactivity of the nano-Pd catalyst was enhanced by incorporating palladium nanoparticles with a chitosan matrix. The synthesized catalyst was thoroughly studied for its structure, morphology, and other fundamental aspects, and showed remarkable stability and reusability for Suzuki cross-coupling reaction with twelve different boronic acids under the green synthetic methodology.
JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Taegun Kim, Bhavana Joshi, Woojin Lim, Edmund Samuel, Ali Aldalbahi, Govindasami Periyasami, Hae-Seok Lee, Seongpil An, Sam S. Yoon
Summary: Flexible piezoelectric nanogenerators (PENGs) using piezopolymer polyvinylidene fluoride (PVDF) and piezoceramic barium titanate (BaTiO3) as flexible composite materials were investigated in this study. The optimized PENG generated a piezoelectric voltage of 11.5 V and achieved a maximum power of 28.7μW. The durability of the PENG was confirmed through 3000 cycles of bending tests and the enhancement of ferroelectric characteristics after electrical poling.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
