期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 14, 页码 4210-4214出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.05.068
关键词
malaria; Plasmodium falciparum; cysteine protease; falcipain-2; peptidomimetic
资金
- Biotechnology and Biological Sciences Research Council [BB/C006321/1] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/C006321/1] Funding Source: researchfish
The structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site. (C) 2008 Elsevier Ltd. All rights reserved.
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