Article
Biochemistry & Molecular Biology
Waleed A. Badawi, Mohamed Samir, Hazem M. Fathy, Tarek M. Okda, Mohamed H. Noureldin, Gamal M. K. Atwa, Omaima M. AboulWafa
Summary: This study focused on the signaling pathway of adenosine diphosphate receptor α1 in lingual osteoblasts and found that hydrazine methyl isoindole has selectivity towards adenosine diphosphate receptor α1. Compared to other pathway inhibitors, hydrazine methyl isoindole shows better selectivity. Furthermore, hydrazine methyl isoindole exhibits significant inhibitory effects on the activity and function of adenosine diphosphate receptor α1 in lingual osteoblasts.
BIOORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Sandra Lucia Teniente, Adriana Carolina Flores-Gallegos, Sandra Cecilia Esparza-Gonzalez, Lizeth Guadalupe Campos-Muzquiz, Sendar Daniel Nery-Flores, Raul Rodriguez-Herrera
Summary: Polyphenols are bioactive phytochemicals with various beneficial activities, including antioxidant, anti-inflammatory, immunomodulatory, and antiviral effects. Extracts from natural sources, such as pomegranate peel extract (PPE), containing polyphenols have shown potential in cancer prevention and treatment. The review summarizes recent scientific reports on the anticancer activity of polyphenols found in PPE, including their mechanisms of action in cervical cancer models.
Article
Biochemistry & Molecular Biology
Feng Qin, Cai Yi Wang, Chun-Gu Wang, Yao Chen, Jin-Jun Li, Mei-Shan Li, Yan-Kui Zhu, Sang Kook Lee, Heng-Shan Wang
Summary: Several previously unknown alkaloids were isolated from Zanthoxylum nitidum, a plant with potential medicinal properties. One of these alkaloids showed significant anti-cancer activity by inhibiting proliferation and migration of cancer cells.
Article
Agriculture, Multidisciplinary
Zhenjiang Ding, Junmin Xi, Miao Zhong, Fan Chen, Huanhuan Zhao, Baoxin Zhang, Jianguo Fang
Summary: The research demonstrates that CYN inhibits PKM2 activity and induces cell cycle arrest, oxidative stress, and mitochondrial damage. However, overexpression of PKM2 attenuates the effects of CYN on cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Wantha Jenkhetkan, Arunporn Itharat, Supranee Kongkham, Srisopa Ruangnoo, Treetip Ratanavalachai
Summary: This study investigated the anti-proliferative efficacy and underlying mechanisms of 10-H2DA co-treatment with DXR in breast cancer cells. The results demonstrated that the combination treatment synergistically inhibited cancer cell growth and induced cell cycle arrest and apoptosis through the modulation of certain proteins.
Article
Biochemistry & Molecular Biology
Cai Yi Wang, Feng Qin, Chun-Gu Wang, Donghwa Kim, Jin-Jun Li, Xian-Lan Chen, Heng-Shan Wang, Sang Kook Lee
Summary: Seven previously undescribed tetrahydrofuran lignans with different configurations and unusual isopentenyl substitutions, along with 14 known lignans, were isolated from Zanthoxylum nitidum. Compound 4, an uncommon naturally occurring furan-core lignan, was derived from tetrahydrofuran aromatization. The study showed that compound 3 exhibited potent antiproliferative activity in cancer cells, including osimertinib-resistant lung cancer cells, by downregulating the activation of certain signaling pathways.
BIOORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Darja Koutova, Negar Maafi, Darina Muthna, Karel Kralovec, Jana Kroustkova, Filip Pidany, Abdul Aziz Timbilla, Eva Cermakova, Lucie Cahlikova, Martina Rezacova, Radim Havelek
Summary: The isoquinoline alkaloids found in Amaryllidaceae have potential for the development of new drugs. In this study, the cytotoxic activities of montanine and its derivatives were evaluated against multiple cancer cell lines, and it was found that montanine exhibited the most potent antiproliferative activity and induced apoptosis in MOLT-4 cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Narissara Namwan, Gulsiri Senawong, Chanokbhorn Phaosiri, Pakit Kumboonma, La-Or Somsakeesit, Arunta Samankul, Chadaporn Leerat, Thanaset Senawong
Summary: The curcumin derivative CU17 shows potential in inhibiting the growth of lung cancer cells, while exhibiting less toxicity to non-cancer cells. CU17 inhibits HDAC activity, induces cell cycle arrest and apoptosis, and down-regulates expression of certain proteins associated with cancer growth in lung cancer cells.
Article
Multidisciplinary Sciences
Nabil A. Alhakamy, Solomon Z. Okbazghi, Mohamed A. Alfaleh, Wesam H. Abdulaal, Rana B. Bakhaidar, Mohammed O. Alselami, Majed Al Zahrani, Hani M. Alqarni, Adel F. Alghaith, Sultan Alshehri, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Omar D. Al-hejaili, Bander M. Aldhabi, Wael A. Mahdi
Summary: In this study, Alendronate sodium (ALS)-mastoparan peptide (MP) nanoconjugates were successfully formulated and optimized using the Box-Behnken response surface design. The results showed that the optimized ALS-MP nanoconjugates exhibited significantly improved cytotoxic activity towards A549 cells. These findings may provide a new solution for the treatment of lung cancer.
Review
Cell Biology
Yasuko Tokunaga, Ken-Ichiro Otsuyama, Naoki Hayashida
Summary: Cell cycle regulation involves various factors, including cyclins and CDKs. Heat shock transcription factors (HSFs) play important roles not only in cell protection but also in immediate gene expression during cell cycle progression.
Article
Biochemistry & Molecular Biology
Xiaoyan Jiang, Xu Zhi, Peixia Zhang, Zhongmei Zhou, Jinxiang Ye, Yu Gao, Xinye Wang, Chuanyu Yang, Haijun Chen, Rong Liu, Ceshi Chen
Summary: The study identified that the isochromanoindolenine derivative FZU-0025-065 inhibits TNBC by suppressing the AKT signaling pathway, showing potential for TNBC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Ying-Hua Luo, Cheng Wang, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Yan-Nan Li, Zhong-Ren Fu, Ying Wang, Cheng-Hao Jin
Summary: The study demonstrated that 18 beta-glycyrrhetinic acid induces apoptosis and G2/M cell cycle arrest, as well as inhibits migration in A549 lung cancer cells through the activation of the ROS/MAPK/STAT3/NF-kappa B signaling pathways.
ONCOTARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Darja Koutova, Radim Havelek, Eva Peterova, Darina Muthna, Karel Kralovec, Katerina Breiterova, Lucie Cahlikova, Martina Rezacova
Summary: Pancracine, a potent compound among natural isoquinolines, exhibited strong antiproliferative activity on A549 cells and induced apoptotic cell death in MOLT-4 cells. The mechanistic understanding of pancracine activity in vitro revealed perturbation of the cell cycle and induction of apoptotic cell death as key mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fei Zhou, Rui Feng, Ou Dai, Lian Yang, Yu Liu, Yun-Cai Tian, Cheng Peng, Liang Xiong
Summary: In this study, phenanthrene derivatives were isolated from the tubers of B. striata and one compound showed cytotoxicity against non-small cell lung cancer cells. It inhibited cell proliferation and migration and promoted cell apoptosis, possibly by regulating Akt, MEK/ERK, and Bcl-2/Bax signaling pathways.
Article
Biochemistry & Molecular Biology
Cheng-Hong Hsieh, Tzu-Yuan Wang, Bo-Chen Tung, Hui-Ping Liu, Lien-Te Yeh, Kuo-Chiang Hsu
Summary: Protein hydrolysates from soy protein isolate showed the greatest inhibition of cell growth. The hydrolysates induced cell cycle arrest and apoptosis in HSC-3 cells.
Article
Biochemistry & Molecular Biology
Seong Ji Woo, Youngmi Kim, Harry Jung, Jae Jun Lee, Ji Young Hong
Summary: In this study, we found that miR-148a may protect against tuberculous pleural fibrosis by inhibiting the expression of NOX4 and POLDIP2, and reducing fibrogenesis and epithelial mesenchymal transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Youlim Kim, Kyungdo Han, Juhwan Yoo, Hyung Koo Kang, Tai Sun Park, Dong Won Park, Ji Young Hong, Ji-Yong Moon, Sang-Heon Kim, Tae Hyung Kim, Kwang Ha Yoo, Jang Won Sohn, Ho Joo Yoon, Hayoung Choi, Hyun Lee
Summary: This study evaluated the risk factors for incident lung cancer in patients with newly diagnosed bronchiectasis using a large nationwide database. The results showed that male sex, overweight, current smoking, living in rural areas, and comorbid chronic obstructive pulmonary disease were independently associated with a higher risk of lung cancer in individuals with bronchiectasis. On the other hand, mild alcohol consumption was negatively associated with lung cancer development in these patients.
Article
Health Care Sciences & Services
Jinkyeong Park, Jae Jun Lee, Yoonki Hong, Hochan Seo, Tae-Seop Shin, Ji Young Hong
Summary: This study revealed significant differences in bacterial microbiota-derived EVs in the plasma of mechanically ventilated patients between pneumonia and non-pneumonia groups, indicating their potential as diagnostic and prognostic markers. Furthermore, variations were also noted in the structure and function analysis of bacterial EVs between 28-day survivors and non-survivors.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Hayoung Choi, Hang A. Park, In Gyu Hyun, Joo-Hee Kim, Yong-Il Hwang, Seung Hun Jang, Yun Su Sim, Tae Rim Shin, Yousang Ko, Ga Young Ban, Ji Young Hong, Chang Youl Lee, Myung Goo Lee, Jeong-Hee Choi
Summary: This study aimed to investigate the incidence of adverse drug reactions (ADRs) to first-line anti-TB drugs and their impact on quality of life (QoL). The results showed that ADRs were common and associated with lower QoL, especially in older adults. However, most patients were able to successfully complete their treatments.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Van Ngo Thai Bich, Tan Khanh Nguyen, Thao Dao Thi Thu, Linh Thuy Thi Tran, Sa Vo Duong Nguyen, Ho Le Han, Long-Hung Dinh Pham, Trung Hoang Thanh, Van Hoa Duong, Tuan Anh Trieu, Manh Hung Tran, Phu Tran Vinh Pham
Summary: This study found that the ethyl acetate fraction extracted from Ampelopsis cantoniensis exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus. Molecular docking and molecular dynamics methods revealed that the main compound, dihydromyricetin, could bind to the bacterial protein PBP2a at an allosteric site, thereby exerting its antibacterial effect. High performance liquid chromatography analysis confirmed dihydromyricetin as the major component of the ethyl acetate fraction. Therefore, natural products derived from Ampelopsis cantoniensis may serve as a potential therapy for methicillin-resistant Staphylococcus aureus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Trang Thi Thu Nguyen, Trinh Thi Tuyet Nguyen, Hoang Duc Nguyen, Tan Khanh Nguyen, Phu Tran Vinh Pham, Linh Thuoc Tran, Linh Thuy Thi Tran, Manh Hung Tran
Summary: In this study, molecular docking simulation was used to evaluate the binding energy of natural secondary metabolites from Ganoderma sp. on S. aureus sortase A. The results showed that ganosinensin B and ganosinoside A had the highest binding energy and stable binding capacity to the protein. In addition, the extracts of Ganoderma sp. exhibited antibacterial activity against S. aureus. These findings provide potential candidates for developing novel drugs to treat S. aureus infection.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Jinkyeong Park, Yoonki Hong, Ji Young Hong
Summary: This study investigated the risk factors for multidrug-resistant tuberculosis (MDR-TB) in patients with pulmonary TB. The research found that patients who had received anti-tumor necrosis factor (TNF) agents had a higher risk of developing MDR-TB. Additionally, males and younger patients were also more susceptible to MDR-TB.
FRONTIERS IN MEDICINE
(2023)
Article
Education, Scientific Disciplines
Trang Thi Thu Nguyen, Hoang Duc Nguyen, Anh Tu Bui, Khanh Huyen Thi Pham, Kim Thuong Pham Van, Linh Thuoc Tran, Manh Hung Tran
Summary: This study identifies a wood decay mushroom, Ganoderma multipileum, associated with the dieback of Delonix regia in Vietnam through morphological analysis and genetic sequencing. The research provides the first documented evidence of Ganoderma multipileum in Vietnam and its connection to the dieback of Delonix regia.
Article
Microbiology
Jinkyeong Park, Seong Ji Woo, Yoonki Hong, Jae Jun Lee, Ji Young Hong
Summary: The correlation between lung microbiome and plasma microbe-derived EVs is different in pneumonia patients and non-pneumonia individuals. mEVs in non-pneumonia patients have a beneficial effect on modulating host lung immune response.
Meeting Abstract
Oncology
Gene Li, Ling Wang, Poonam Yakkundi, Paul Hinton, Deepal Pandya, Keerthana Sekar, Rodine Rosete, Zhongde Ye, Nardeen Hanna, Maya F. Kotturi, Liz Bogaert, Jiyoung Hong, Christina Tsai, Thomas Manley, Bruce A. Keyt, Angus M. Sinclair, Liqin Liu
Meeting Abstract
Respiratory System
Taehee Kim, Sang Hyuk Kim, Hayoung Choi, Tae Rim Shin, Hwan Il Kim, Seung Hun Jang, Ji Young Hong, Myung Goo Lee, Soojie Chung, In Gyu Hyun, Yun Su Sim
Meeting Abstract
Respiratory System
Jeongmi Lee, Yoonki Hong, Ji-Young Hong, Jinkyeong Park
Meeting Abstract
Respiratory System
Jae Kyeom Sim, Sang-Min Lee, Hyung Koo Kang, Kyung Chan Kim, Young Sam Kim, Yun Seong Kim, Won-Yeon Lee, Sunghoon Park, So Young Park, Ju-Hee Park, Yun Su Sim, Kwangha Lee, Yeon Joo Lee, Jin Hwa Lee, Heung Bum Lee, Chae-Man Lim, Won-Il Choi, Ji Young Hong, Won Jun Song, Gee Young Suh
Article
Chemistry, Multidisciplinary
Tan Khanh Nguyen, Linh Thuy Thi Tran, Trung Truong Tan, Phu Tran Vinh Pham, Linh Thuy Khanh Nguyen, Hoai Thi Nguyen, Duc Viet Ho, Manh Hung Tran
Summary: Two styryl-lactone derivatives (1 and 2) were isolated from the aerial parts of Goniothalamus elegans. Compound 1 is a newly discovered natural product, and compound 2 is reported in this plant for the first time. Both compounds showed potent cytotoxicity against cancer cell lines, with compound 1 displaying a strong binding affinity for EGFR and HER-2 proteins. ADMET predictions suggested that these compounds can be absorbed in the gastrointestinal tract and penetrate the blood-brain barrier. These findings suggest that further studies should be conducted to explore their potential as active ingredients for cancer treatment.
Article
Plant Sciences
Chuong Ngoc Nguyen, Hieu Thi Hong Nguyen, Dieu Thuong Thi Trinh, Thi Hong Van Le, Tuan Duc Nguyen, Dinh Vinh, Dao Cuong To, Loi Huynh, Manh Hung Tran
Summary: In this study, two novel secondary metabolites and eight known compounds were isolated and identified from the extract of Vietnamese Lycopodium casuarinoides. The flavonoids (2R,3R)-dihydrokaempferol and apigenin showed significant inhibitory activity against nitric oxide production, indicating potential anti-inflammatory effects. Structural variations in guaiacyl glyceryls salcolin A and salcolin B were also found to be related to their activity.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
