期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 7, 页码 2414-2419出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.02.049
关键词
chemokine; chemokine antagonist; CXCR3; IP-10; CXCL10; multiple sclerosis; benzimidazole; 2-iminobenzimidazole
Modi. cation of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an 8-quinoline amide and conformational rigidification of an aliphatic tether furnished potent compounds suitable for further lead optimization. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据