Article
Biochemistry & Molecular Biology
Haowen Zhang, Gomika Udugamasooriya
Summary: Targeting cytoskeletal proteins uniquely translocated to cancer cell surface, the peptoid JM3A has been optimized and dimerized to achieve an antagonist effect on cancer cell proliferation and viability.
BIOORGANIC CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Zachary S. Clauss, Jessica R. Kramer
Summary: This study presents a facile method for synthesizing polypeptoids via transition-metal-catalyzed controlled polymerization, yielding high-molecular-weight linear polypeptoids with predictable length and low dispersity. These materials are resistant to protease degradation and well-tolerated by human cells, showing promise for biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Cell Biology
Adiv A. Johnson, Trinna L. Cuellar
Summary: The restriction of calories, branched-chain amino acids, and methionine have been shown to extend lifespan in model organisms. Recently, glycine was found to boost longevity in genetically heterogenous mice. This simple amino acid similarly extends lifespan in rats and improves health in mammalian models of age-related disease. Existing evidence suggests that glycine prolongs life by mimicking methionine restriction and activating autophagy.
AGEING RESEARCH REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Wei Zhang, Xiaoli Guo, Jing Ren, Yujiao Chen, Jingyu Wang, Ai Gao
Summary: The study aimed to explore the effects of benzene on metabolism, especially in amino acid metabolism, in human peripheral blood B lymphocyte cells treated with 1,4-benzoquinone (1,4-BQ) and in benzene-exposed population based on the untargeted and targeted metabolomics platforms. Results showed that 1,4-BQ disturbed metabolic activity, upregulated the ratio of sarcosine/glycine, and implied the involvement of the glycine/GNMT/sarcosine axis in benzene-induced hematotoxicity.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Microbiology
Mengshuang Liu, Hui Liu, Fangtong Mei, Niping Yang, Dahe Zhao, Guomin Ai, Hua Xiang, Yanning Zheng
Summary: Thioalkalivibrio versutus D301 is used in biodesulfurization process due to its ability to oxidize hydrogen sulfide to elemental sulfur under strongly halo-alkaline conditions. Glycine betaine contributes to increased tolerance to extreme environments in some Thioalkalivibrio species. In this study, it was found that genes associated with nitrogen metabolism of T. versutus D301 were upregulated under high-salt conditions, leading to enhanced production of glycine betaine as a compatible solute to salinity stress. Glycine betaine is synthesized through glycine methylation pathway in T. versutus D301, with GMT and SDMT identified as key enzymes in this process.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Physical
A. M. Petrosyan, V. V. Ghazaryan, G. Giester
Summary: Crystalline sulfamate salts of glycine, sarcosine, and dimethylglycine were characterized and compared with the known salt of betaine. The compounds showed different symmetry and structural properties.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Physiology
Carsten Uhd Nielsen, Nanna Friberg Krog, Ilham Sjekirica, Sidsel Strandgaard Nielsen, Maria L. Pedersen
Summary: Solute carriers (SLC) play a crucial role in the uptake of sarcosine and glycine in prostate cancer cells, and hyperosmotic stress can affect their uptake.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Haipei Zhao, Mingqiang Li, Shasha Lu, Nan Cao, Xiaolei Zuo, Shaopeng Wang, Min Li
Summary: Enzyme clustering is widely used to improve catalytic efficiency in cascade reactions. Organizing enzymes within a cascade reaction is of great interest in basic research and industrial processes. Enzyme modification is a crucial step for precise organization of enzymes in vitro, but preserving enzyme activity during modification is challenging. Here, we present an enzyme conjugation method that rescues the reduction of enzymatic activity caused by DNA labeling. This method involves immobilizing DNA-modified enzymes on tetrahedral DNA nanostructures, resulting in enhanced enzymatic activity. We demonstrate the utility of this method by developing an ultra-sensitive and high-throughput electrochemical biosensor for sarcosine detection, which could be valuable for prostate cancer screening.
Article
Chemistry, Physical
Jinyoung Oh, Yongmoon Lee, Gahee Noh, Dongcheol Park, Hohjai Lee, Junseong Lee, Changsoon Kim, Jiwon Seo
Summary: Controlling the chirality of chromophores in three-dimensional space is important for understanding the relationship between structure and chiroptical properties. In this study, the authors synthesized optically active multipyrene systems on peptoids, demonstrating the control of optical activity through peptoid secondary structure homogeneity. The resulting peptoids exhibited circularly polarized luminescence (CPL) through intramolecular excimer generation. The study highlights the role of conformational homogeneity in modulating CPL activity and handedness.
Article
Microbiology
D. Y. Sorokin
Summary: This study enriched for GB-utilizing bacteria and archaea from sediments of hypersaline soda lakes in southwestern Siberia. Gamma-proteobacterial strains and sulfur-reducing haloarchaea were isolated under different conditions, demonstrating their ability to utilize various methylated compounds for growth.
Article
Chemistry, Multidisciplinary
Madison Monahan, Bin Cai, Tengyue Jian, Shuai Zhang, Guomin Zhu, Chun-Long Chen, James J. De Yoreo, Brandi M. Cossairt
Summary: Peptoids, with a structure similar to proteins, offer a versatile platform for assembling structures with atomic precision. This study demonstrated successful assembly of CdSe QDs using peptoid tubes and sheets via covalent linkages, providing control over QD density. The compatibility and control of CdSe-peptoid interactions through varying peptoid structures and CdSe particles were shown to create complex hybrid structures.
Article
Biochemistry & Molecular Biology
Limei Zhong, Youlin Zhu, Kenneth M. Olsen
Summary: This study used genome scans to uncover selection marks of hard and soft sweeps in domesticated soybeans, revealing that hard sweeps are mainly present in domesticated soybeans, while soft sweeps are more common in wild ancestors. The results contribute to a better understanding of genetic characteristics of domestication traits in soybeans.
Article
Chemistry, Multidisciplinary
Jinrong Ma, Biao Jin, Kathryn N. Guye, Md. Emtias Chowdhury, Nada Y. Y. Naser, Chun-Long Chen, James J. J. De Yoreo, Francois Baneyx
Summary: This article introduces a method using peptoid nanotubes to template the synthesis of inorganic mineralization, successfully achieving systematic control of crystallite size and fabricating various materials, including gold nanoparticles and titania/gold nanocomposites. The study uncovers the critical roles of hierarchical organization and denticity in solid-binding protein mineralization outcomes and provides a valuable strategy for fabricating hierarchical hybrid materials with a broad range of inorganic components.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Liwei Zhao, Jian Yang, Ming Gong, Ke Li, Jinlou Gu
Summary: The study proposes a novel strategy for screening prostate cancer patients by detecting sarcosine in urine samples. Using hierarchical mesoporous Zr-based metal-organic frameworks, the study successfully identified the minor concentration changes of sarcosine in urine samples between PCa patients and healthy individuals.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Muhammad Asif Ahmad Khushaini, Nur Hidayah Azeman, Ahmad Ghadafi Ismail, Chin-Hoong Teh, Muhammad Mat Salleh, Ahmad Ashrif A. Bakar, Tg Hasnan Tg Abdul Aziz, Ahmad Rifqi Md Zain
Summary: This study utilized the RS mechanism, formed by electrochemical redox-reactions, and a novel organic molecule, BOBzBT(2), to modify the SPE electrode for creatinine sensing. By optimizing the concentration of BOBzBT(2) during CV measurements, the sensor's sensitivity was enhanced, showing potential for practical application in detecting creatinine levels.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kimberly R. Mendes, Marie Lynne Malone, John Maina Ndungu, Irena Suponitsky-Kroyter, Valerie J. Cavett, Patrick J. McEnaney, Andrew B. MacConnell, Todd. M. Doran, Katharina Ronacher, Kim Stanley, Ofelia Utset, Gerhard Walzl, Brian M. Paegel, Thomas Kodadek
ACS CHEMICAL BIOLOGY
(2017)
Article
Chemistry, Medicinal
Osayemwenre Erharuyi, Scott Simanski, Patrick J. McEnaney, Thomas Kodadek
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Chemistry, Applied
Keitou Shu, Thomas Kodadek
ACS COMBINATORIAL SCIENCE
(2018)
Article
Chemistry, Applied
Nam Tran-Hoang, Thomas Kodadek
ACS COMBINATORIAL SCIENCE
(2018)
Article
Chemistry, Applied
Kevin Pels, Paige Dickson, Hongchan An, Thomas Kodadek
ACS COMBINATORIAL SCIENCE
(2018)
Editorial Material
Pharmacology & Pharmacy
Animesh Roy, Thomas Kodadek
TRENDS IN PHARMACOLOGICAL SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Animesh Roy, Eric Koesema, Thomas Kodadek
Summary: A powerful quality control method has been developed to distinguish efficiently cyclizing scaffolds during solid-phase synthesis of thioether macrocycles without the need for tedious liquid chromatography/mass spectrometry analysis. This method can also identify linear impurities in a DNA-encoded library of macrocycles and establish a useful quality control protocol for re-synthesis of putative macrocyclic screening hits.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Eric Koesema, Animesh Roy, Nicholas G. Paciaroni, Carlos Coito, Michal Tokmina-Roszyk, Thomas Kodadek
Summary: This study reports a solid-phase synthesis method for constructing a DNA-encoded library of thioether-linked macrocycles. The library is designed to be highly diverse and minimize the number of amide N-H bonds to enhance cell permeability. The results demonstrate the utility of this library as a source of protein ligands, with the successful isolation of compounds that bind the model target, Streptavidin, with high affinity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Paige Dickson, Daniel Abegg, Ekaterina Vinogradova, Junichiro Takaya, Hongchan An, Scott Simanski, Benjamin F. Cravatt, Alexander Adibekian, Thomas Kodadek
CELL CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Paige Dickson, Scott Simanski, John Maina Ngundu, Thomas Kodadek
CELL CHEMICAL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Patrick McEnaney, Madeline Balzarini, Hajeung Park, Thomas Kodadek
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Nicholas G. Paciaroni, John M. Ndungu, Thomas Kodadek
CHEMICAL COMMUNICATIONS
(2020)
Review
Chemistry, Multidisciplinary
Thomas Kodadek, Nicholas G. Paciaroni, Madeline Balzarini, Paige Dickson
CHEMICAL COMMUNICATIONS
(2019)
Review
Chemistry, Organic
Paige Dickson, Thomas Kodadek
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Article
Neurosciences
Na Feng, Scott Simanski, Kazi Islam, Linda S. Hynan, Thomas Kodadek, Dwight C. German
NPJ PARKINSONS DISEASE
(2018)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
