Article
Chemistry, Multidisciplinary
P. Ramu, S. P. Vimal, P. Suresh, Anandhavelu Sanmugam, U. Saravanakumar, Raju Suresh Kumar, Abdulrahman I. Almansour, Natarajan Arumugam, Dhanasekaran Vikraman
Summary: The PEDOT-GO-PPO sensor was fabricated for dopamine detection, with the morphology and oxidation-reduction characteristics studied for optimization. Analysis of the detection limit and linear range data showcased the performance advantages of the modified electrode.
Article
Chemistry, Medicinal
Youzhi Wang, Huifang Wang, Guoqing Yang, Qingjing Hao, Kan Yang, Huizhen Shen, Yulong Wang, Jinxin Wang
Summary: It is well known that COPD patients suffer from chronic inflammation and oxidative stress. In this study, a novel class of PDE4 inhibitors with antioxidant properties were identified from natural products and synthesized to design bifunctional compounds. These compounds showed better PDE4 inhibitory activity than the original inhibitor and superior radical scavenging abilities. They also exhibited anti-inflammatory effects and stability in vivo.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Amelia B. Chen, Qing Shao, Carol K. Hall
Summary: This study explores the mechanism of DOPA and amyloid peptide conjugates as new underwater adhesives, confirming through molecular simulations that DOPA does not aggregate at low concentrations and showing the possibility of both intra-chain folding and no chain folding in the conjugates.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Felisbela Gomes, Shih-Lung Cheng
Summary: Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by airway limitation and changes in airway structure. It has a high global burden of mortality and morbidity. Inhaled antimuscarinic drugs are a key component of therapy for COPD, and there remains a need for drugs that can modify the course of the disease.
Article
Infectious Diseases
Vakhtang Barbakadze, Maia Merlani, Lali Gogilashvili, Lela Amiranashvili, Anthi Petrou, Athina Geronikaki, Ana Ciric, Jasmina Glamoclija, Marina Sokovic
Summary: The antimicrobial activities of biopolymers extracted from six plants of Boraginaceae family were studied. Moderate antibacterial activities were observed, with only three plants showing activities against all tested bacteria. On the other hand, better antifungal activity was observed, with the biopolymers from Borago officinalis stems exhibiting the best activities.
Article
Multidisciplinary Sciences
Heng Li, Xianglei Zhang, Caigui Xiang, Chunlan Feng, Chen Fan, Moting Liu, Huimin Lu, Haixia Su, Yu Zhou, Qing Qi, Yechun Xu, Wei Tang
Summary: Arctigenin, a selective inhibitor of phosphodiesterase-4, demonstrates significant anti-inflammatory effects in human PBMCs and murine RAW264.7 cells. In an imiquimod-induced murine psoriasis model, topical application of arctigenin ameliorated psoriatic manifestations by reducing adhesion and chemotaxis of inflammatory cells. Proteomics analysis showed that arctigenin rectified immune dysfunction and hyperactivation of keratinocytes in the inflamed skin microenvironments, suggesting its therapeutic potential for psoriasis treatment.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Lidia Puertas-Umbert, Judith Alonso, Leif Hove-Madsen, Jose Martinez-Gonzalez, Cristina Rodriguez
Summary: This review summarizes the role of the PDE4 subfamily in cardiovascular function and highlights the challenges associated with targeting PDE4 enzymes as a therapeutic strategy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Rui Zhang, Heng Li, Xianglei Zhang, Jian Li, Haixia Su, Qiukai Lu, Guangyu Dong, Huixia Dou, Chen Fan, Zhanni Gu, Qianwen Mu, Wei Tang, Yechun Xu, Hong Liu
Summary: A series of novel tetrahydroisoquinoline derivatives were developed and compound 36 exhibited significant inhibitory effects against PDE4D enzymatic activity and TNF-α release, showing more significant efficacy in improving psoriasis-like skin inflammation compared to calcipotriol.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Barbara Meier-Schiesser, Mark Mellett, Marigdalia K. Ramirez-Fort, Julia-Tatjana Maul, Annika Klug, Nicola Winkelbeiner, Gabriele Fenini, Peter Schafer, Emmanuel Contassot, Lars E. French
Summary: Apremilast demonstrated significant therapeutic effects in a psoriasis mouse model and human cells, showing remarkable improvements in reducing skin lesions and inhibiting inflammatory responses. While not directly affecting inflammasome activation, the indirect benefits of PDE4 inhibition were evident in reducing inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Cem Erkmen, Yeliz Demir, Sevinc Kurbanoglu, Bengi Uslu
Summary: A novel multi-purpose amperometric nanobiosensor based on tyrosinase enzyme was developed for determination of phenolic compounds, catechol, epinephrine, and norepinephrine. The biosensor was optimized for various parameters and showed efficient detection capabilities in different samples, including pharmaceutical dosage forms and human serum.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Biochemistry & Molecular Biology
Jian Jin, Francesca Mazzacuva, Letizia Crocetti, Maria Paola Giovannoni, Agostino Cilibrizzi
Summary: Cyclic nucleotide phosphodiesterases 4 (PDE4) are enzymes that promote the hydrolysis and degradation of cAMP. Inhibiting PDE4 enzymes has been studied as an alternative strategy for treating respiratory diseases and autoimmune disorders. This review summarizes the medicinal chemistry research on designing effective PDE4 inhibitors, focusing on their chemical classes, structural aspects, binding properties, inhibitory efficacy, PDE4 selectivity, and therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Spectroscopy
Le Wang, Yue Sun, Hao Zhang, Wenqi Shi, Hui Huang, Yongxin Li
Summary: In this study, a novel sensing device for catechol was developed using a fluorescent nanozyme Cu-BDC-NH2. The nanozyme showed efficient catechol oxidase activity and could both recognize catechol and provide a signal output. This method allows for the convenient and selective detection of catechol without the need for additional chromogenic agents.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Neurosciences
Mostofa Jamal, Asuka Ito, Takanori Miki, Shingo Suzuki, Ken-Ichi Ohta, Hiroshi Kinoshita
Summary: This study investigated the effects of ethanol on dopamine, norepinephrine, and serotonin levels in the mouse brain. The results showed that high concentrations of ethanol can accelerate dopamine metabolism, possibly due to increased activity of monoamine oxidase.
NEUROSCIENCE LETTERS
(2022)
Article
Microbiology
Cosimo Kropp, Julius Lipp, Anna Lena Schmidt, Christina Seisenberger, Mona Linde, Kai-Uwe Hinrichs, Patrick Babinger
Summary: As a characteristic feature of Archaea, ether lipids are found in their cell membranes. However, Bacteria have also been found to possess Archaea-like ether lipids, although with some differences in composition. YvoF, an acetyltransferase, has been identified in both Bacillales (Bacteria) and Halobacteria (Archaea), suggesting a shared mechanism for lipid modification. Acetylated diether lipids have been discovered in the Halobacterial species Haloferax volcanii and Halobacterium salinarum, which may have implications for the polarity of lipid headgroups and potentially unknown biological effects.
Review
Chemistry, Medicinal
Gang Li, Dengqin He, Xiaojia Cai, Wen Guan, Yali Zhang, Jia-Qiang Wu, Hongliang Yao
Summary: Phosphodiesterase 4 (PDE4) is crucial in various biological processes by hydrolyzing cyclic adenosine monophosphate (cAMP). PDE4 inhibitors have been extensively studied as potential therapeutics for diseases like asthma, chronic obstructive pulmonary disease (COPD), and psoriasis. However, the development of PDE4 inhibitors for COPD and psoriasis has been hindered by side effects such as emesis. This review summarizes the recent advancements in the development of PDE4 inhibitors, focusing on PDE4 sub-family selectivity, dual target drugs, and therapeutic potential, with the aim of facilitating the development of novel PDE4 inhibitors as potential drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Alexandre Kiazand, Ruth Luther, Jessica Marlind Wuertele, Noel Southall, Douglas Domalik, Magnus Ysander
Summary: The COVID-19 vaccine effort was the fastest global response to a health crisis in history, allowing for the evaluation and improvement of pharmaceutical industry pharmacovigilance practices to enhance safety signal detection, evaluation, and communication.
NATURE REVIEWS DRUG DISCOVERY
(2023)
Article
Hematology
Joshua Bennett, Chiharu Ishikawa, Puneet Agarwal, Jennifer Yeung, Avery Sampson, Emma Uible, Eric Vick, Lyndsey C. Bolanos, Kathleen Hueneman, Mark Wunderlich, Amal Kolt, Kwangmin Choi, Andrew Volk, Kenneth D. Greis, Jan Rosenbaum, Scott B. Hoyt, Craig J. Thomas, Daniel T. Starczynowski
Summary: This study reveals the functional compensation and complementation of IRAK1 in leukemic cells upon inhibition of IRAK4. Cotargeting IRAK1 and IRAK4 is necessary to suppress leukemic stem/progenitor cell function and induce differentiation. IRAK1 and IRAK4 maintain the undifferentiated state of MDS/AML LSPCs through noncanonical MyD88-independent pathways.
Article
Oncology
Tyler J. Peat, Snehal M. Gaikwad, Wendy Dubois, Nana Gyabaah-Kessie, Shuling Zhang, Sayeh Gorjifard, Zaw Phyo, Megan Andres, Keith Hughitt, R. Mark Simpson, Margaret A. Miller, Andrew T. Girvin, Andrew Taylor, Daniel Williams, Nelson D'Antonio, Yong Zhang, Adhithi Rajagopalan, Evan Flietner, Kelli Wilson, Xiaohu Zhang, Paul Shinn, Carleen Klumpp-Thomas, Crystal McKnight, Zina Itkin, Lu Chen, Dickran Kazandijian, Jing Zhang, Aleksandra M. Michalowski, John K. Simmons, Jonathan Keats, Craig J. Thomas, Beverly A. Mock
Summary: Drug resistance and disease progression are common in MM patients. A study identified 43 potentially synergistic combinations through drug screening and in silico analysis. These combinations effectively reduce MYC expression and enhance p16 activity, leading to improved viability and prolonged survival in MM models.
Article
Oncology
William C. Reinhold, Kelli Wilson, Fathi Elloumi, Katie R. Bradwell, Michele Ceribelli, Sudhir Varma, Yanghsin Wang, Damien Duveau, Nikhil Menon, Jane Trepel, Xiaohu Zhang, Carleen Klumpp-Thomas, Samuel Micheal, Paul Shinn, Augustin Luna, Craig Thomas, Yves Pommier
Summary: Significant progress has been made in precision medicine for cancer treatment, but there are still unanswered questions that need to be addressed. CellMinerCDB: NCATS is a web application that provides activity information for various drugs and compounds, including nononcology drugs and unique compounds. It integrates multiple forms of data and offers analysis tools for exploring drug response in cancer cell lines.
Article
Chemistry, Multidisciplinary
Brice Martin, Tyler Garman, Madeline Laramee, Amy Wang, Xiaohu Zhang, Erin Beck, Kelli Wilson, Carleen Klumpp-Thomas, Crystal McKnight, Xin Xu, Natalie Hagen, David Holland, Nadia Dahmane, Craig J. Thomas, Mark Souweidane
Summary: In this study, a high-throughput screen was conducted on a human patient-derived CPC cell line, identifying 427 potential targets and providing new strategies for CPC treatment. Two combination therapies (topotecan/elimusertib and melphalan/elimusertib) were validated in vitro and in vivo, leading to increased survival in a CPC genetic mouse model. This study identifies multiple promising combinatorial therapeutics for CPC and highlights the potential of intra-arterial delivery in CPC treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Martin Lang, Laura S. Schmidt, Kelli M. Wilson, Christopher J. Ricketts, Carole Sourbier, Cathy D. Vocke, Darmood Wei, Daniel R. Crooks, Youfeng Yang, Benjamin K. Gibbs, Xiaohu Zhang, Carleen Klumpp-Thomas, Lu Chen, Rajarshi Guha, Marc Ferrer, Crystal McKnight, Zina Itkin, Darawalee Wangsa, Danny Wangsa, Amy James, Simone Difilippantonio, Baktir Karim, Francisco Moris, Thomas Ried, Maria J. Merino, Ramaprasad Srinivasan, Craig J. Thomas, W. Marston Linehan
Summary: The study identified several potential therapeutic agents for treating advanced MiT-RCC, including PI3K/mTOR inhibitor NVP-BGT226, transcription inhibitor Mithramycin A, and GPNMB-targeted antibody-drug conjugate CDX-011. Preclinical studies demonstrated the efficacy of these agents in vitro and in vivo, providing potential treatment options for patients with MiT-driven RCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Junko Murai, Michele Ceribelli, Haiqing Fu, Christophe E. Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I. Aladjem, Craig J. Thomas, Yves Pommier
Summary: Schlafen 11 (SLFN11) is a predictive biomarker and molecular sensor for a wide range of clinical drugs. A high-throughput screen was conducted to identify drugs that target SLFN11, and it was found that the neddylation inhibitor pevonedistat and the DNA polymerase a inhibitor AHPN/CD437 induced SLFN11 chromatin recruitment. Pevonedistat recruited SLFN11 at late time points (24 hours), and SLFN11-deficient cells showed increased unscheduled re-replication after 24 hours. However, SLFN11-proficient cells blocked this re-replication. The study suggests that SLFN11 could serve as a predictive biomarker for pevonedistat in clinical trials.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Oncology
Sebastian Scheich, Jiji Chen, Jiamin Liu, Frank Schnutgen, Julius C. Enssle, Michele Ceribelli, Craig J. Thomas, Jaewoo Choi, Vivian Morris, Tony Hsiao, Hang Nguyen, Boya Wang, Arnold Bolomsky, James D. Phelan, Sean Corcoran, Henning Urlaub, Ryan M. Young, Bjorn Haupl, George W. Wright, Da Wei Huang, Yanlong Ji, Xin Yu, Weihong Xu, Yandan Yang, Hong Zhao, Jagan Muppidi, Kuan-Ting Pan, Thomas Oellerich, Louis M. Staudt
Summary: Diffuse large B-cell lymphoma (DLBCL) can be categorized into two subtypes: activated B-cell (ABC) and germinal center B cell-like (GCB). The study found that self-antigen engagement of B-cell receptors (BCR) in ABC tumors triggers clustering, activating chronic active signaling and NF-KB and PI3 kinase. Genome-wide CRISPR-Cas9 screens were used to identify regulators of IRF4, a direct transcriptional target of NF-KB and an indicator of proximal BCR signaling in ABC DLBCL. Inactivation of N-linked protein glycosylation by the OST-B complex reduced IRF4 expression and targeting OST-B inhibition killed models of ABC and GCB DLBCL, suggesting the potential for selective OST-B inhibitors in treating these aggressive cancers.
Article
Biochemistry & Molecular Biology
David B. Morse, Aleksandra M. Michalowski, Michele Ceribelli, Joachim De Jonghe, Maria Vias, Deanna Riley, Theresa Davies-Hill, Ty Voss, Stefania Pittaluga, Christoph Muus, Jiamin Liu, Samantha Boyle, David A. Weitz, James D. Brenton, Jason D. Buenrostro, Tuomas P. J. Knowles, Craig J. Thomas
Summary: Single-cell RNA sequencing (scRNA-seq) is used to describe cell states, but the spatial arrangement of these states in tissues is challenging. Segmentation by exogenous perfusion (SEEP) is a method that links surface proximity and environment accessibility to transcriptional identity within 3D disease models. Using SEEP, analysis of ovarian cancer models reveals the relationship between cell state and position, and shows how microenvironments influence individual cell identities.
Article
Biochemical Research Methods
Emma J. Chory, Meng Wang, Michele Ceribelli, Aleksandra M. Michalowska, Stefan Golas, Erin Beck, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Kelli M. Wilson, David Holland, Sanjay Divakaran, James Bradner, Javed Khan, Berkley E. Gryder, Craig J. Thomas, Benjamin Z. Stanton
Summary: We conducted a comprehensive study on drug synergy in acute myeloid leukemia (AML), using a panel of cell lines representing different subtypes. Our study provides a valuable resource for the community, offering many unexpected synergistic drug combinations and open source code for automation and analysis. We identified drug synergies that affect the chromatin state, particularly in relation to the modification of histone H3 lysine-27. Additionally, we developed an open source high throughput methodology that allows multidimensional drug screening with widely accessible equipment.
Article
Medicine, Research & Experimental
Anju Kumari, Lisa Gesumaria, Yan-Jin Liu, V. Keith Hughitt, Xiaohu Zhang, Michele Ceribelli, Kelli M. Wilson, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Craig J. Thomas, Beverly A. Mock, David S. Schrump, Haobin Chen
Summary: Small cell lung cancer (SCLC) is a difficult-to-treat malignancy and current treatment options are limited. This study identified that mTOR inhibitors (mTORis) show the highest synergy with BET inhibitors (BETis) in SCLC, enhancing their antitumor activities both in vitro and in vivo. Mechanistically, BETis induce apoptosis in SCLC by activating the intrinsic apoptotic pathway, but also upregulate RSK3 to promote survival. However, mTORis block this survival signaling and augment the apoptosis induced by BET inhibition. Combination therapy of mTORis and BETis has potential for further evaluation in SCLC patients.
Article
Multidisciplinary Sciences
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A. Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K. Egan, Ellen Murchie, Michele Ceribelli, Giovanna S. Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L. Boisvert, Leah J. Damon, Kelli M. Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J. Garnett, Jeffrey A. Engelman, Daniel A. Haber, Craig J. Thomas, Eytan Ruppin, Cyril H. Benes
Summary: Combination of anti-cancer drugs is commonly used to overcome limited efficacy of single agents. Designing and testing combinations are challenging due to the heterogeneity of tumor response. Co-targeting functionally proximal genes may result in higher efficacy, offering a strategy for more efficient combinations.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Jerry T. Wu, Adam Cheuk, Kristine Isanogle, Christina Robinson, Xiaohu Zhang, Michele Ceribelli, Erin Beck, Paul Shinn, Carleen Klumpp-Thomas, Kelli M. Wilson, Crystal Mcknight, Zina Itkin, Hiroshi Sotome, Hiroshi Hirai, Elizabeth Calleja, Volker Wacheck, Brad Gouker, Cody J. Peer, Natalia Corvalan, David Milewski, Yong Y. Kim, William D. Figg, Elijah F. Edmondson, Craig J. Thomas, Simone Difilippantonio, Jun S. Wei, Javed Khan
Summary: Rhabdomyosarcoma (RMS) is a common pediatric soft tissue sarcoma. Futibatinib, an irreversible pan-FGFR inhibitor, shows efficacy in inhibiting the growth of RMS cell lines in vitro by targeting FGFR4. However, limited efficacy is observed in animal models, suggesting the need for alternative treatment strategies.
Article
Public, Environmental & Occupational Health
Jiyoon Park, Malek Djelassi, Daniel Chima, Robert Hernandez, Vladimir Poroshin, Ana-Maria Iliescu, Douglas Domalik, Noel Southall
Summary: This study aims to validate an automated deep learning approach to literature surveillance for use at AstraZeneca. The results show that the model demonstrates consistent global performance compared to human surveillance teams. The prospective evaluation of model performance allows for a thorough examination of its consistency and failure modes, qualifying it for use in their surveillance processes.
Article
Chemistry, Medicinal
Damien Y. Duveau, Craig J. Thomas
Summary: The SARS-CoV-2 main protease is an important target for therapeutic interventions against COVID-19. The first approved inhibitor, Nirmatrelvir, shows activity against cysteine proteases and has significant therapeutic implications.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
