Article
Chemistry, Multidisciplinary
Joanna Czescik, Susanna Zamolo, Tamis Darbre, Riccardo Rigo, Claudia Sissi, Adam Pecina, Laura Riccardi, Marco De Vivo, Fabrizio Mancin, Paolo Scrimin
Summary: Gold nanoparticles can efficiently catalyze chemical reactions as nanozymes, exhibiting the highest efficiency in cleaving plasmid DNA. By successfully mimicking the suggested structure of natural metallonucleases, this study provides important insights into the catalytic mechanism.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Jia-Hui Liu, Xue-Jiao Lv, Yan-Kai Liu
Summary: An asymmetric retro-Claisen reaction of alpha-mono-substituted beta-diketones and quinones (or quinone imine) has been developed using a chiral aza-bisoxazoline-Zn(II) complex as a catalyst. The reaction involves conjugate addition, arylation, hemiketal anion-initiated C-C bond cleavage, and enantioselective protonation of enolate, leading to the formation of functionalized alpha-arylated ketones with a tertiary stereogenic center in high enantioselectivities. Importantly, biologically significant benzofuran and gamma-butyrolactone derivatives can be synthesized using this protocol.
Article
Chemistry, Inorganic & Nuclear
Ding Pei-Pei, Li Ming, Wu Yu, Yan Jun-Tao, Wang Chun-Lei, Wang Yang, Mao Jia-Wei
Summary: A bis-pyridine pendant-armed macrocyclic heterobinuclear Zn(II)-Ni(II) complex has been synthesized and characterized. The structure and interaction of the complex with CT-DNA has been investigated.
CHINESE JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
A. Sakthivel, B. Thangagiri, N. Raman, J. Joseph, Ramu Guda, Mamatha Kasula, L. Mitu
Summary: Novel macrocyclic Schiff base complexes with different metal ions have been synthesized and characterized, showing promising antioxidant, antimicrobial, and anticancer activities. The interaction of the complexes with DNA through the macrocyclic ligand and the inhibitory effects on target proteins such as EGFR and HER2 have been investigated and demonstrated.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Jianfang Dong, Lei Gao, Bo Zhang, Tao Xu, Lei Wang, Jinming Kong, Lianzhi Li
Summary: A mononuclear nickel(II) complex, [Ni(o-van-tris)(2)]·2H(2)O, has been synthesized and structurally characterized. The complex interacts with CT-DNA through hydrogen bond and hydrophobic interactions, showing efficient DNA cleavage activity. Molecular docking studies reveal effective docking of the complex in the major groove of DNA, and the DNA cleavage is concentration dependent and sensitive to ionic strength.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Physical
Bhushan S. Sail, Vinod H. Naik, B. M. Prasanna, Naushad Ahmad, Mohammad Rizwan Khan, M. R. Jagadeesh, Ravikumar Cheedarala
Summary: Many Schiff bases derived from 2-hydrazinobenzothiazole and isatin have been used to form [ML2]Cl2 type Co(II) complexes. Nitrogen from azomethine, oxygen from lactonyl, and nitrogen atoms of the thiazole ring contribute to coordinating the metallic ion. The complexes consist entirely of metal and have a geometrical octahedron structure, as confirmed by analytical, magnetic, and spectroscopic investigations.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Shazia Parveen, Farukh Arjmand, Qianfan Zhang, Musheer Ahmad, Arif Khan, Loic Toupet
Summary: In this study, the synthesis and single crystal X-ray structure of Cu(II)-picolinic acid complex, 1 as a potent topoisomerase I inhibitor was reported. Biochemical studies revealed the complex's higher binding propensity towards tRNA, significant inhibitory effect on enzyme catalytic activity, and strong antimicrobial potential. Additionally, DFT and molecular docking studies provided insights into electronic transitions and specific binding preferences at the target site.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Inorganic & Nuclear
Natalija Pantalon Juraj, Tana Tandaric, Vanja Tadic, Berislav Peric, Dominik Moreth, Ulrich Schatzschneider, Anamaria Brozovic, Robert Vianello, Srecko Kirin
Summary: In this study, the coordination properties of ligands were investigated by modifying their side chain structure. The results showed that the length of the aliphatic linker, isomers of the amide group, and the type of chiral terminal group all had an impact on the coordination properties. Additionally, DFT calculations provided insights into the stability of isomers and the potential hydrogen bonding between ligands in a ML2 complex.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Applied
Shimaa Hosny, Gamal A. Gouda, Samy M. Abu-El-Wafa
Summary: A series of new solid Cr(II), Co(II), Cu(II), Pd(II), and Cd(II) chelates were synthesized and characterized. Cu nano complexes showed potential antitumor activity and DNA cleavage ability.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Dameng Sun, Xin Huang, Ruojun Man, Xinjie Jia, Xinluan Song, Sihan Wang, Xingyong Xue, Hongming Liu, Zhen Ma
Summary: A series of Fe(ii) complexes were synthesized using modified terpyridine ligands, and they exhibited high antiproliferation activities against human cancer cell lines with low toxicity to normal cells. The carboxyl-modified complex showed significant selectivity in killing hepatoma cancer cells. These Fe(ii) complexes have potential as anticancer drugs against hepatoma cancer.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Applied
Azizollah Beheshti, Maryam Bahrani-Pour, Maryam Kolahi, Ehsan Shakerzadeh, Hossein Motamedi, Peter Mayer
Summary: Two new mono- and dinuclear zinc (II) complexes have been synthesized and characterized with tetrahedral coordination structure. Both complexes exhibit antibacterial and anticancer properties, with complex 1 showing higher DNA cleavage activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Adel Z. El-Sonbati, Mostafa A. Diab, Ahmed K. El-Sayed, Mohamed Abou-Dobara, Sameh A. El-Sayad
Summary: Metal complexes of a Schiff base ligand derived from 2,4-dihydroxybenzaldehyde and p-nitroaniline were synthesized and characterized. The complexes showed antibacterial, antifungal, and cytotoxic activities, and the ligand exhibited high binding affinity to various receptors.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Abdellatif A. Helaly, Ashraf A. El-Bindary, Shadia A. Elsayed
Summary: Azo dye ligand and its metal chelates were synthesized and characterized. Their binding affinity with DNA, anticancer and antimicrobial activities, as well as their interactions with COVID-19 and prostate cancer receptors, were investigated.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
P. Priya, P. Jayaseelan, S. Vedanayaki
Summary: Transition metal(II) chelates were prepared using bis-Schiff base ligands, which were investigated through different analytical techniques. The complexes showed efficient antibacterial activity and good interaction with DNA.
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Zeinab Mirzaei-Kalar, Ali Akbar Khandar, Jonathan M. White, Hoda Abolhasani, Tahereh Komeili Movahhed, Stephen P. Best, Abolghasem Jouyban
Summary: After the accidental discovery of cis-platinum, extensive research has been done on designing metallic compounds for cancer treatment. A solvent-dependent complex of nickel (II) with 1,10-phenanthroline and naproxen has been synthesized and its in vitro DNA binding and cytotoxicity on cancer cells have been studied. The results show that the complex has better inhibition on HT 29 cancer cells compared to cisplatin, but lower inhibition on HEK-293 normal cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Microbiology
Shuman Zhang, Tiansheng Chen, Jia Jia, Liwen Guo, Huizheng Zhang, Chao Li, Renzhong Qiao
Article
Chemistry, Physical
J. K. Bai, D. Chen, C. Li, H. S. Wang, R. Z. Qiao
Article
Chemistry, Organic
Jiakun Bai, Xiaolin Sun, Haisheng Wang, Chao Li, Renzhong Qiao
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Materials Science, Biomaterials
Yi Yuan, Luqing Zhao, Cuiyun Shen, Ye He, Feng Yang, Ganlin Zhang, Mengdi Jia, Rong Zeng, Chao Li, Renzhong Qiao
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Physical
Hongwei Qiao, Jiakun Bai, Mengyao Zhu, Juanhong Gao, Anna, Sichun Zhang, Chao Li
Article
Medicine, Research & Experimental
Cuiyun Shen, Luqing Zhao, Xueying Du, Jiaxin Tian, Yi Yuan, Mengdi Jia, Ye He, Rong Zeng, Renzhong Qiao, Chao Li
Summary: The GC-B-Que micelles exhibit pH/ROS dual-responsive properties and sustained release behavior, showing better therapeutic efficacy than free drugs in treating colitis. These micelles have the potential for oral delivery and provide an alternative strategy for designing smart responsive nanocarriers for catechol-based drugs.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Luqing Zhao, Xueying Du, Jiaxin Tian, Xiuhong Kang, Yuxin Li, Wenlin Dai, Danyan Li, Shengsheng Zhang, Chao Li
Summary: Inflammatory bowel disease (IBD) is a refractory disorder characterized by chronic inflammation related to oxidative stress and high concentrations of reactive oxygen species (ROS). A new oxidation-responsive nano prodrug OC-B-BBR displayed stability and ideal drug release behavior. This study demonstrated that the prodrug significantly ameliorated colitis symptoms and colon damage, regulating gut microbiota expression levels and reshaping the community.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Anna, Zhaohang Chen, Hongwei Qiao, Juanhong Gao, Mengyao Zhu, Chao Li
Summary: A series of xanthone derivatives were synthesized by rhodium-catalyzed cycloaddition and sequential oxidation, demonstrating wide applicability. The derivatives showed excellent yields and different substituent electron effects, highlighting the potential of the proposed approach. The successful one-pot synthesis from 1ethynyl-2-phenoxybenzene further emphasized the attractiveness of the current method for xanthone synthesis.
CATALYSIS COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Zhaohang Chen, Pengcheng Zhou, Yuanxia Guo, Anna, Jiakun Bai, Renzhong Qiao, Chao Li
Summary: A guanosine-based hydrogel with self-supporting and transparent characteristics was constructed. This hydrogel can catalyze the aldol reaction in water without additives, showing good yield and enantioselectivity.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhaohang Chen, Shuai Wang, Kangjie Liu, Rui Zhang, Qiaoying Li, Weiguang Bian, Renzhong Qiao, Chao Li
Summary: A practical, economical, and scalable process for the synthesis of a key intermediate for olaparib was reported in this study, utilizing a low-cost industrial byproduct phthalhydrazide as starting material. Optimization of each step led to an environmentally benign and robust process with effective impurity control.
Article
Nanoscience & Nanotechnology
Hongyue Wang, Lin Wang, Shasha Guo, Zehao Liu, Luqing Zhao, Renzhong Qiao, Chao Li
Summary: An active flavonoid compound, rutin, was incorporated into a guanosine phenylborate hydrogel (GBR) for the treatment of inflammatory bowel disease (IBD). The hydrogel exhibited good stability and injectability, and achieved dual-responsive release in an acidic pH and excessive ROS-containing medium. In vivo studies showed that the GBR hydrogel had higher therapeutic efficacy than free rutin and could suppress the expression of inflammatory cytokines.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Zhaohang Chen, Yuanxia Guo, Huilong Niu, Jinxin Wang, Jianming Li, Chao Li, Renzhong Qiao
Summary: The new synthetic route allows for the preparation of intermediate 5 of irbesartan in four steps from low-cost glycine methyl ester, avoiding the use of highly toxic cyanide. The spirocycle structure in intermediate 5 is constructed via a simple alkylation reaction with dihaloalkanes. The scale-up production process successfully yielded 332 g of intermediate 5 with high purity and overall yield, demonstrating a viable alternative strategy for irbesartan production.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Green & Sustainable Science & Technology
Shuai Wang, Zhaohang Chen, Jincheng Zhao, Kangjie Liu, Chao Li, Renzhong Qiao
Summary: Non-β-lactam β-lactamase inhibitors have significant clinical significance in restoring the antibacterial effect of antibiotics. In this study, a method for the separation and purification of avibactam, a non-β-lactam β-lactamase inhibitor containing a sulfonic acid group, was developed using gemini quaternary ammonium salts. The precipitation process of a specific gemini quaternary ammonium salt was successfully applied to the separation and purification of a large-scale avibactam production, providing an efficient and green approach.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Multidisciplinary
Hongwei Qiao, Jiakun Bai, Sichun Zhang, Chao Li
Article
Chemistry, Medicinal
Z. H. Chen, H. Zhou, S. Wang, G. Li, J. Zhang, F. Wang, C. Li, R. Z. Qiao
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
