Review
Biotechnology & Applied Microbiology
Changyun Sun, Mila Janjic Rankovic, Matthias Folwaczny, Sven Otto, Andrea Wichelhaus, Uwe Baumert
Summary: This systematic review summarizes the role of hPDLCs in mechanosensing and mechanotransduction during orthodontic tooth movement, as well as the effects of tension application on genes, proteins, and metabolites, along with the identification of signaling pathways involved. It provides important insights for future research in this field.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Cell Biology
Wei He, Yu Fu, Song Yao, Lan Huang
Summary: The periodontal ligament consists of fibroblasts, cementoblasts, osteoblasts, osteoclasts, periodontal ligament stem cells (PDLSCs), and epithelial cell rests of Malassez. The regulation of programmed cell death is important for immune response but can also lead to the loss of periodontal supporting tissues and root resorption. These findings are relevant for understanding periodontitis and orthodontic root resorption. This comprehensive review focuses on recent studies on mechanisms of periodontal ligament cell death.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Jun Mi, Shuangshuang Wang, Panpan Liu, Chang Liu, Dexuan Zhuang, Xue Leng, Qun Zhang, Fuxiang Bai, Qiang Feng, Xunwei Wu
Summary: Periodontal ligament stem cells (PDLSCs) are a type of cells with self-renewal capability and multidirectional differentiation potential. This study reveals that CUL4B plays a role as a new regulator in the osteogenic differentiation of PDLSCs. It cooperates with the PRC2 complex to repress the expression of miR-320c and miR-372/373-3p, leading to the upregulation of RUNX2, a master transcription factor (TF) that regulates osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yi Zhao, Qiaoli Zhai, Hong Liu, Xun Xi, Shuai Chen, Dongxu Liu
Summary: TRIM16 plays a crucial role in osteogenic differentiation of human periodontal ligament stem cells by stabilizing the RUNX2 protein levels. It may be a potential target for stem cell-based bone regeneration in periodontal therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Wenfang Wang, Meijuan Wang, Xiaomei Guo, Yunshan Zhao, Madiha Mohammed Saleh Ahmed, Hong Qi, Xi Chen
Summary: The osteoblastic differentiation of periodontal ligament stem cells (PDLSCs) under mechanical tensile force is frequency-dependent. EYA1 and SALL1 were identified as potential important tensile frequency-sensitive genes, which may contribute to the cyclic tension-induced osteogenic differentiation of PDLSCs in a frequency-dependent manner.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Cell Biology
Andrew C. Tamashunas, Aditya Katiyar, Qiao Zhang, Purboja Purkayastha, Pankaj K. Singh, Sasanka S. Chukkapalli, Tanmay P. Lele
Summary: The study found that in a mouse model of periodontal disease, periodontal ligament fibroblasts (PdLFs) exhibit rounded and disoriented nuclei, indicating reduced actomyosin tension. Inhibiting actomyosin contractility decreased levels of bone regulatory protein osteoprotegerin (OPG). Infection with periodontal bacteria did not replicate the observed nuclear rounding in vivo.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rahyza I. F. Assis, Arthur G. Schmidt, Francesca Racca, Rodrigo A. da Silva, William F. Zambuzzi, Karina G. Silverio, Francisco H. Nociti, Vanessa G. Pecorari, Malgorzata Wiench, Denise C. Andia
Summary: This study investigated the heterogeneity in osteogenic potential of periodontal ligament cells (PDLCs) and explored the enhancement of osteogenic differentiation through epigenetic modulation. The findings suggest a role of DNMTs and TETs in osteogenic commitment, supporting the potential application of epigenetic approaches in regulating biomineralization in PDLCs.
DNA AND CELL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ni Xiong, Jung-Sub An, Heein Yoon, Hyun-Mo Ryoo, Won Hee Lim
Summary: This study reveals the critical role of the Runx2 gene in the homeostasis of the periodontal complex, particularly in the integrity of cementum and attachment of periodontal fibers.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Immunology
Shuangshuang Li, Huilin Xu, Yuanyuan Li, Ruijing Li
Summary: In this study, it was found that circular RNA_0138960 promotes dysfunction in LPS-induced periodontal ligament cells by targeting the miR-518a-5p/HDAC6 axis, providing new potential therapeutic targets for periodontitis.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xilei Zhu, Livia von Werdt, Graziano Zappala, Anton Sculean, Sigrun Eick, Alexandra Stahli
Summary: The study demonstrates the beneficial effect of cross-linked hyaluronic acid (cHA) on periodontal wound healing and regeneration. The application of cHA in the gingival sulcus during non-surgical periodontal therapy has positive effects.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biochemistry & Molecular Biology
Judit Symmank, Sophie Appel, Jana Asisa Bastian, Isabel Knaup, Jana Marciniak, Christoph-Ludwig Hennig, Annika Doding, Ulrike Schulze-Spate, Collin Jacobs, Michael Wolf
Summary: This study aimed to investigate the effects of hyperlipidemia and bacterial infection on cytokine expression and secretion in HPdLF cells. The results showed that hyperlipidemic conditions increased the susceptibility of HPdLF to inflammatory response to compressive forces, especially when cells were simultaneously exposed to bacterial components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Agnes Schroeder, Ricarda Schoeniger, Juliane Oeldemann, Gerrit Spanier, Peter Proff, Jonathan Jantsch, Christian Kirschneck, Niklas Ullrich
Summary: The effects of compressive strain on gene expression profiles of periodontal ligament fibroblasts (PDLFs) during orthodontic treatment were investigated in different 3D cell culture models. The results showed that the expression profiles of PDLFs varied depending on the 3D structure used. This highlights the importance of selecting appropriate 3D structures when studying the effects of mechanical strain on cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ioannis Tsamesidis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Evgenia Lymperaki, Chrysanthi Papoulia, Karine Reybier, Pierre Perio, Konstantinos M. Paraskevopoulos, Eleana Kontonasaki, Anna Theocharidou
Summary: In this study, ART-loaded cerium-doped mesoporous calcium silicate nanopowders were synthesized and evaluated for their hemocompatibility and cell proliferation. The NPs showed good biocompatibility and ROS scavenging properties, promoting cell proliferation effectively.
Article
Multidisciplinary Sciences
Hirotsugu Oka, Shinichirou Ito, Mana Kawakami, Hodaka Sasaki, Shinichi Abe, Satoru Matsunaga, Sumiharu Morita, Taku Noguchi, Norio Kasahara, Akihide Tokuyama, Masataka Kasahara, Akira Katakura, Yasutomo Yajima, Toshihide Mizoguchi
Summary: The lineage of periodontal ligament stem cells is important for the formation of alveolar bone and cementum. LepR(+) PDL cells have stem cell characteristics and their number increases with age. Both LepR(+) and LepR(-) PDL cells can differentiate into hard tissue, with some expressing LepR.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fan Gu, Hailin Wu, Zhuo Huang, Fei Wang, Ruihuan Yang, Zhuan Bian, Miao He
Summary: This study demonstrates that PDLFs and DPCs are more sensitive to cytoplasmic LPS-induced noncanonical pyroptosis and that DMF treatment can block cell death. This suggests that DMF might be a promising drug for the management of pulpitis and apical periodontitis.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Rheumatology
Hai Wang, Chunling Wang, Qin Wan, Li Li
Summary: Elevated serum IgG4 level is commonly observed in IgG4-RD and other diseases, especially in chronic diseases of various organs. Serum IgG4 and IgG4/IgG have significant value for the diagnosis and treatment evaluation of IgG4-RD.
CLINICAL RHEUMATOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Chenjing Li, Yihua Feng, Jingyao Li, Rui Lian, Liehao Qin, Chunling Wang
Summary: A novel polysaccharide, PSPP-A, extracted from purple sweet potato, was investigated for its structural characteristics and preventive effects on NAFLD. The results showed that PSPP-A mainly contained arabinose and had certain preventive effects. This study provides a theoretical basis for further elucidating the hepatoprotective effect of purple sweet potatoes as a functional food.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjun Wang, Vitaliy Zhurbenko, Juan Diego Sanchez-Heredia, Jan Henrik Ardenkjaer-Larsen
Summary: To improve the decoupling of preamplifiers, their noise figure can be sacrificed. This study establishes the relation between the preamplifier noise figure and decoupling, and proposes a method to design the corresponding decoupling networks. The approach is proven to significantly increase the decoupling of coils.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Engineering, Environmental
Jun Gong, Zheye Zhang, Shibo Xi, Wenjun Wang, Jianmei Lu, Peng Chen
Summary: Interlayer engineering is crucial for enhancing the performance of two-dimensional materials in catalysis. In this study, GQD/Co-MoS2 was successfully synthesized and showed excellent long-term stability and catalytic performance. The outstanding performance can be attributed to the enlarged interlayer spacing and electronic coupling at the van der Waals heterojunctions between GQDs and Co-doped MoS2.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Optics
Longxue Cao, Yang Shen, Bing Lei, Wei Zhou, Shuhong Li, Yunlong Liu, Yu Lu, Kai Zhang, Hao Ren, Yan-Qing Li, Jian-Xin Tang, Wenjun Wang
Summary: A method of controlling the crystallization of reduced-dimensional mixed-halide blue perovskite films by adjusting the precursor concentration is proposed, improving the efficiency and stability of sky-blue and pure-blue perovskite light-emitting diodes (PeLEDs).
LASER & PHOTONICS REVIEWS
(2023)
Review
Optics
Kai Zhang, Long-Xue Cao, Yingyi Tang, Yi Yu, Yang Shen, Bingfeng Wang, Wen-Jun Wang, Yan-Qing Li, Jian-Xin Tang
Summary: This review focuses on the key factors and strategies for blue emission PeLEDs, including effective methods for obtaining blue emission and significant improvements based on different structural materials. Challenges in efficiency, stability, lead toxicity, and fabrication techniques are summarized, and future research directions are discussed.
LASER & PHOTONICS REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Yanbo Zhu, Zi Yan, Changhao Fu, Xue Wen, Lin Jia, Lei Zhou, Zhonghua Du, Cong Wang, Yichen Wang, Jingcheng Chen, Yuanyuan Nie, Wenjun Wang, Jiuwei Cui, Guixia Wang, Andrew R. Hoffman, Ji-Fan Hu, Wei Li
Summary: By combining CRIST-seq and RNA sequencing, researchers identified a pluripotency-associated lncRNA Osilr9, which plays a critical role in maintaining the pluripotency of stem cells by coordinating the promoter activity of core stem cell factor genes. Osilr9 binds to the Oct4 promoter and recruits a DNA demethylase to induce promoter demethylation, thus facilitating the maintenance of pluripotency.
Article
Environmental Sciences
Wenjun Wang, Nina Khanna, Jiang Lin, Xu Liu
Summary: Black carbon is a harmful byproduct of incomplete combustion and China plays a significant role in global black carbon emissions. This study provides an inventory of black carbon emissions in China for 2015 and projects emissions for 2016-2050 under different scenarios. Residential use is the largest contributor to black carbon emissions in China, followed by coke production, industry, agricultural waste burning, and transportation. The study shows that an accelerated reduction scenario could result in much faster and deeper reductions in black carbon emissions across all sectors.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Microbiology
Chunling Wang, Yi Xiao, Yong Wang, Yumin Liu, Qing Yao, Honghui Zhu
Summary: In this study, comparative genomics and transcriptomics were used to analyze metabolic potentials and differentially expressed genes in different myxobacteria strains. The results revealed metabolic deficiencies and various protein secretion systems in myxobacteria. RNA-seq data showed overexpression of potential predation genes during prey consumption. A working model for multiple predatory strategies by M. xanthus was proposed. These findings may inspire research on the development of novel antibacterial strategies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Vitaliy Zhurbenko, Wenjun Wang, Juan Diego Sanchez Heredia, Jan Henrik Ardenkjar-Larsen
Summary: Cryogenically cooled MRI coils with high-Q factors can increase bandwidth using a preamplifier decoupling, preserving spectral components of magnetic resonance signals and reducing detuning from coupling to surrounding structures. This method is not only applicable to 13C isotope imaging in 3-Tesla MRI systems, but also to other applications of high-Q coils, such as low-field MRI systems.
IEEE SENSORS LETTERS
(2023)
Article
Materials Science, Ceramics
Qingzhen Zheng, Xuesong Mei, Gedong Jiang, Jianlei Cui, Zhengjie Fan, Wenjun Wang, Zhaoxuan Yan, Hang Guo, Aifei Pan
Summary: This paper proposes a novel ultrasonic vibration-assisted femtosecond laser polishing method for C/SiC composites. The near-field convection enhancement of ultrasonic vibration improves cooling and reduces bonding of ablated particles to the material surface, resulting in reduced oxidation, improved surface quality, removal depth, and material removal rate. By optimizing defocusing distance and scanning speed, a specific relationship between ultrasonic amplitude, pulse energy density, and spot overlap rate was established, achieving a smooth and defect-free surface. The coupling effect of ultrasonic and laser energy fields enhances the residual compressive stress of carbon fibers, explaining the formation of typical features such as fiber fracture and pulling-out, banded pits, voids, and deposition. This paper presents new research ideas for understanding the removal mechanism of C/SiC composites using ultrasonic vibration-assisted femtosecond laser.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Spectroscopy
Wang Wen-jun, Sha Yun-fei, Wang Yang-zhong, Yu Jie, Liu Tai-ang, Zhang Xu-feng, Meng Xiang-zhou, Ge Jiong
Summary: In this study, a qualitative discrimination model based on NIR and EN was established to distinguish the flavors of tobacco leaves. The combined model showed higher prediction accuracy for intermediate and strong flavors compared to NIR and EN alone. The study also compared different data mining algorithms and found that artificial neural network had higher modeling accuracy but lower prediction accuracy compared to support vector machine. This study can support the rapid identification of tobacco flavor style and provide an auxiliary identification method for professional tobacco evaluators.
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2023)
Article
Hematology
Lijuan Zhang, Kankan Chen, Yingying Li, Qiuni Chen, Wenting Shi, Tingting Ji, Hong Tao, Zhengmei He, Chunling Wang, Liang Yu
Summary: This study explored the clinical outcomes and characteristics of TP53-mutated primary myelodysplastic syndromes (MDS). The results showed that TP53-mutated patients had a higher frequency of cytogenetic abnormalities, with 5q- karyotype, complex karyotype, high-risk MDS, and acute myelogenous leukemia transformation. Moreover, TP53-mutated patients had lower mean corpuscular volume (MCV) and were more sensitive to HMA treatment. However, they had worse overall survival and leukemia-free survival compared to TP53 wild-type patients, and TP53 mutation was identified as an independent adverse prognostic factor.
Article
Hematology
Yue Chen, Junhui Wang, Jingjing Ma, Linrong Fei, Qiuni Chen, Shandong Tao, Zhengmei He, Chunling Wang, Liang Yu
Summary: This study aimed to assess the value of nutritional status in predicting the prognosis of myelodysplastic syndromes (MDS) patients. The results showed that a better nutritional status was associated with improved overall survival (OS) in MDS patients, while there were no statistical differences in progression-free survival (PFS) between the two groups. Furthermore, the prognostic nutritional index (PNI) was found to be a useful tool for evaluating the OS of MDS patients.
Article
Biology
Liquan Shen, Haoxiang Gao, Jiayi Wu, Gong Wang, Rui Liu, Jun Qi, Xueyan Zhang, Aiping Zhang, Lei Chen, Yizhen Zhang, Chunling Wang, Dongming Qi, Yanqun Wang, Xiuxiang Meng
Summary: Suitable birth-site habitat is vital for the survival of alpine musk deer. They prefer habitats with higher elevation, steeper slopes, taller arbor and shrub canopies, more ground-plant cover, and more fallen trees. The ecological variables that affect their habitat selection include shrub canopy, ground-plant cover, number of fallen trees, and slope. Alpine musk deer also prioritize habitats with good concealment, minimal human activity interference, and proximity to water sources.