期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 22, 期 20, 页码 5638-5656出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2014.06.021
关键词
Biocatalyst; Artificial enzyme; Oxidation; Reduction; C-C bond formation/cleavage
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- JST, Japan
- NAIST, Japan
- Grants-in-Aid for Scientific Research [25105738] Funding Source: KAKEN
Recent development in biochemical experiment techniques and bioinformatics has enabled us to create a variety of artificial biocatalysts with protein scaffolds (namely 'artificial enzymes'). The construction methods of these catalysts include genetic mutation, chemical modification using synthetic molecules and/or a combination of these methods. Designed evolution strategy based on the structural information of host proteins has become more and more popular as an effective approach to construct artificial protein-based biocatalysts with desired reactivities. From the viewpoint of application of artificial enzymes for organic synthesis, recently constructed artificial enzymes mediating oxidation, reduction and C-C bond formation/cleavage are introduced in this review article. (C) 2014 Elsevier Ltd. All rights reserved.
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