期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 22, 期 17, 页码 4948-4954出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2014.06.039
关键词
Palladium(II) complex; Breast cancer; Apoptosis; Cytotoxicity
资金
- University of Uludag [UAP(F)-2011/41]
- Scientific Research Projects Coordination Unit of Istanbul University [30869]
The anti-growth effect of a palladium(II) complex-[PdCl(terpy)](sac)center dot 2H(2)O] (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine)-was tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. Anti-growth effect was assayed by the MTT and ATP viability assays in vitro and then confirmed on Balb/c mice in vivo. The mode of cell death was determined by both histological and biochemical methods. The Pd(II) complex had anti-growth effect on a dose dependent manner in vitro and in vivo. The cells died by apoptosis as evidenced by the pyknotic nucleus, cleavage of poly-(ADP-ribose) polymerase (PARP) and induction of active caspase-3. These results suggest that the palladium(II) saccharinate complex of terpyridine represents a potentially active novel complex for the breast cancer treatment, thus warrants further studies. (C) 2014 Elsevier Ltd. All rights reserved.
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