期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 22, 期 1, 页码 585-593出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.10.049
关键词
Glycyrrhetinic acid derivatives; Cytotoxicity; Nitric oxide; Biological activity; Selectivity index
资金
- RAS [10]
- RFBR [12-04-31254]
- SB RAS [104]
- Scientific School by the Ministry of education and science of Russian Federation [2972.2012.4, 8277]
Here we report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring glycyrrhetinic acid bearing a 2-cyano-3-oxo-1-en moiety in the A-ring and double bonds and carbonyl groups in the C, D and E rings. Bioassays using murine macrophage-like and tumor cells show that compound 4, which differs from Soloxolone methyl by the absence of a 9(11)-double bond in the C-ring, displays anti-inflammatory and inhibitory activities with respect to tumor cells with a high selectivity index value. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据