期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 13, 页码 3859-3865出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.04.021
关键词
Pyrazole; Acyl thiourea; Anticancer activity; Liver; Colon; Leukemia cell lines
资金
- Turkish National Academy of Sciences [TUBA GEBIP 2008-29]
In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in good yield through one pot reaction of 4-benzoyl-1, 5-diphenyl-1H-pyrazole-3-carbonyl chloride with ammonium thiocyanate and various amines. The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR and elemental analysis. Anticancer activities of synthesized compounds were evaluated on human colon, liver and leukemia cancer cell lines. Cell culture studies have demonstrated significant toxicity of the compounds on the cell lines, and the levels of toxicity have altered in the presence of various side groups. These results confirm that novel pyrazolyl acyl thioureas derived compounds may be utilized for cancer treatment. Furthermore, these compounds have a great potential and significance for further investigations. (C)2013 Elsevier Ltd. All rights reserved.
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