期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 13, 页码 3702-3707出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.04.027
关键词
Artemisinin-derived dimer; CMV; Leukemia; Phosphate ester
资金
- NIH [R37 AI34885, R01 AI093701, PO1 CA70970]
- National Foundation for Cancer Research
- Maryland Stem Cell Research Foundation/TEDCO [2010-MSCRFII-0065]
- Curing Kids Cancer Foundation
- William Lawrence & Blanche Hughes Foundation
We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells. (C) 2013 Elsevier Ltd. All rights reserved.
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