期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 21, 期 23, 页码 7453-7464出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2013.09.043
关键词
Adenosine receptor; Xanthine; A(2A); Hypoxia; KW-6002; Synthesis
资金
- NCI NIH HHS [R01 CA111985] Funding Source: Medline
- NIAID NIH HHS [U19 AI091693] Funding Source: Medline
Molecular modeling techniques were applied to the design, synthesis and optimization of a new series of xanthine based adenosine A(2A) receptor antagonists. The optimized lead compound was converted to a PEG derivative and a functional in vitro bioassay used to confirm efficacy. Additionally, the PEGylated version showed enhanced aqueous solubility and was inert to photoisomerization, a known limitation of existing antagonists of this class. (C) 2013 Elsevier Ltd. All rights reserved.
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