☆ 4.7 Article

C-(α-D-Glucopyranosyl)-phenyldiazomethanes-irreversible inhibitors of α-glucosidase

BIOORGANIC & MEDICINAL CHEMISTRY (2013)

期刊

BIOORGANIC & MEDICINAL CHEMISTRY

卷 21, 期 16, 页码 4793-4802

出版社

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.bmc.2013.05.055

关键词

alpha-Glucosidase; Irreversible inhibition; Diazo compounds; Carbohydrate; Synthesis

类别

Biochemistry & Molecular Biology Chemistry, Medicinal Chemistry, Organic

资金

King Abdulaziz University [26-3-1432/HiCi]
KAU
University of Konstanz
Fonds der Chemischen Industrie

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Protocol

Reagent

摘要

Several C-(alpha-p-glucopyranosyl)-phenyldiazomethanes, with different substituent groups at the para-position of the phenyl ring, were prepared. The stabilities of these diazo compounds were investigated through NMR and UV monitoring. The para-cyano substituted diazo compound was found to be stable in neutral media (pH 7.0 buffer) and could be isolated. Inhibitory activity investigations indicated that this compound is an irreversible inhibitor against alpha-glucosidase from Saccharomyces cerevisiae. (C) 2013 Elsevier Ltd. All rights reserved.

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