Article
Chemistry, Multidisciplinary
Yucheng Ma, Zeyan Zhuang, Longjiang Xing, Jianqing Li, Zhiwen Yang, Shaomin Ji, Rong Hu, Zujin Zhao, Yanping Huo, Ben Zhong Tang
Summary: The study introduces a series of red fluorophores as organelle-targeting antitumor photosensitizers with aggregation-induced emission characteristics, showing promising efficacy in killing cancer cells and inhibiting tumor growth in living mice.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Xiaolu Guo, Naidi Yang, Wenhui Ji, Hang Zhang, Xiao Dong, Zhiqiang Zhou, Lin Li, Han-Ming Shen, Shao Q. Yao, Wei Huang
Summary: Traditional cancer therapies such as surgery, chemotherapy, and radiotherapy have limited effectiveness, while photodynamic therapy, photothermal therapy, and chemodynamic therapy have shown promising results in cancer treatment due to their high selectivity, minimal resistance, and minimal toxicity.
ADVANCED MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Abhishek Pawar, Swati Korake, Atmaram Pawar, Ravindra Kamble
Summary: The mitochondria, as a vital organelle, plays a significant role in cancer therapy. By attaching mitochondrial-targeting moieties to chemotherapeutics, fluorescent dyes, and photothermal molecules, the anticancer effect can be greatly enhanced. Triphenyl phosphonium (TPP) is the most widely used mitochondrial targeting conjugate, with amplified therapeutic outcomes in the treatment of various cancers.
CURRENT DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Isabel Wen Badon, Jun-Pil Jee, Temmy Pegarro Vales, Chanwoo Kim, Seungbin Lee, Jaesung Yang, Si Kyung Yang, Ho-Joong Kim
Summary: The straightforward synthesis of three cationic boron-dipyrromethene (BODIPY) derivatives and their mitochondria-targeting and photodynamic therapeutic (PDT) capabilities are reported. The halogenated BODIPY dyes exhibit lower fluorescence quantum yields and enable the efficient production of singlet oxygen species. The synthesized dyes displayed good PDT capabilities against cancer cell lines, with low cytotoxicity in the dark, demonstrating the potential of cationic BODIPY-based dyes as therapeutic drugs for anticancer photodynamic therapy.
Article
Biochemistry & Molecular Biology
Wei Liu, Xingqun Ma, Yingying Jin, Jie Zhang, Yang Li, Yuxia Tang, Yong Song, Shouju Wang
Summary: Ce6-biotin has higher binding affinity to biotin-receptor-positive tumor cells and exhibits stronger cytotoxicity with lower dark toxicity compared to its precursor, Ce6, making it a promising photosensitizer for BR-positive-tumor-targeting photodynamic therapy.
Review
Chemistry, Inorganic & Nuclear
Christopher C. Rennie, Robert M. Edkins
Summary: Phototherapy, using light to selectively ablate cancerous tissue, shows promising prospects. The use of Pc-drug conjugates as targeted anticancer phototherapeutic systems has shown potential in improving treatment specificity and achieving precise, synergistic phototherapy.
DALTON TRANSACTIONS
(2022)
Article
Nanoscience & Nanotechnology
Nan Zheng, Xiaoqin Luo, Zhiyi Zhang, Aiguo Wang, Wangze Song
Summary: This study introduces a library of polymerized and cationic photosensitive drugs (pPSs) with HIF-1 alpha siRNA delivery capability for gene therapy. By using a ROS-cleavable linker, successful segregation of PS monomers was achieved, enhancing the PDT effect. The drug exhibited desired siRNA delivery and gene silencing both in vitro and in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Medicinal
Qiaoyun Jiang, Peixia Li, Jingru Qiu, Donghai Li, Guiling Li, Gang Shan
Summary: The development of safe and effective photosensitizers is crucial for improving photodynamic cancer therapy. In this study, a new redshift phenalenone derivative, SDU Red, was developed as a lysosome-targeting photosensitizer for triple-negative breast cancer therapy. SDU Red exhibited good photostability and a remarkable phototherapeutic index against triple-negative breast cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Pei Luo, Yongkang Zhang, Junqing Zhang, Hao Zhang, Chun Yang, Changhua Li
Summary: This article proposes a supramolecular strategy to engineer a switchable photosensitizer through mitochondria-mediated dynamic interconversion, enabling specific activation of mitochondria-targeting photodynamic therapy and hibernation after mitochondria damage. By spatial and temporal control, therapeutic efficacy is enhanced and off-target damage is reduced.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Oncology
Muhammad Danish Yaqoob, Long Xu, Chuanfeng Li, Merrin Man Long Leong, Dan Dan Xu
Summary: Photodynamic therapy (PDT) is a noninvasive therapeutic modality that uses light to target mitochondria, which plays a crucial role in cancer and anticancer therapy. Mitochondria-targeting sensitizers, such as IR-730 and IR-Pyr, have shown promise in improving the efficacy of PDT for solid tumors.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Materials Science, Multidisciplinary
Liying Pan, Shihua Wang, Mintao Xie, Manshan Liang, Lichao Yu, Bing Du, Xiaoxia Ye, Yanshu Luo, Yun-Yun Quan, Zu-Sheng Huang
Summary: Rational design of organelle targeted therapeutic platform is an effective approach to improve treatment outcomes and minimize cytotoxicity. In this study, a photosensitizer TSPy-B was designed with biotin receptor and mitochondria dual-targeted capability, and high ROS generation efficiency for fluorescence imaging guided PDT. Cell imaging experiments demonstrated that TSPy-B could selectively target tumor cells with biotin receptor overexpression and exhibited mitochondria targeting ability. In vitro and in vivo experiments further confirmed the anticancer mechanism and therapeutic efficacy of TSPy-B.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Inorganic & Nuclear
Zilin Zhu, Li Wei, Yidan Lai, Oliver W. L. Carter, Samya Banerjee, Peter J. Sadler, Huaiyi Huang
Summary: Rationally-designed glucose-appended Ir(III) photocatalysts were found to exhibit visible light-induced catalytic NAD(P)H oxidation in aqueous solution. Among them, the highly in vivo biocompatible complex Ir3 showed lysosome and mitochondria targeting necro-apoptotic photo-cytotoxicity against various cancer cell lines and multicellular spheroids while remaining non-toxic in the dark.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Multidisciplinary
Andrew M. Korolchuk, Vladimir A. Zolottsev, Alexander Y. Misharin
Summary: Photodynamic therapy is a minimally invasive treatment that uses photosensitizers, light, and reactive oxygen species to destroy cellular structures in tumors. Recent advancements in the field have focused on creating new photosensitizers, particularly tetrapyrrolic macrocycles, that specifically target cancer cells through structural modification and conjugation with biologically active molecules. This review highlights the design, preparation, and investigation of complex conjugates of tetrapyrrolic macrocycles for target-oriented photodynamic therapy of cancer, discussing their structure, photodynamic effect, and anticancer activity.
TOPICS IN CURRENT CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Zhen Sun, Weihua Chen, Jianhua Liu, Bin Yu, Chunhuan Jiang, Lehui Lu
Summary: This work introduces a well-designed Fe-doped Bi2S3 nanoneedle that localizes to mitochondria, producing extra ROS with inherent photothermal effect, and demonstrates enhanced therapeutic effect by combining photodynamic therapy (PDT) and photothermal therapy (PTT) targeting mitochondria.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Yongfei Zhao, Ke Xue, Jing Deng, Zhengjian Qi
Summary: We designed and synthesized a near-infrared emission aggregation-induced emission photosensitizer (AIE-PS) that can target different subcellular organelles in a time-dependent manner. This AIE-PS showed broad absorption and excellent type I reactive oxygen species (ROS) generation efficiency, surpassing widely used photosensitizers. With short-term incubation, the AIE-PS anchored on the cell membrane and gradually entered the mitochondria of cancer cells, exhibiting excellent time-dependent fluorescence imaging effect. Furthermore, this AIE-PS achieved selective photodynamic therapy (PDT) in a time-dependent manner under white light irradiation. This work provides a new approach for cancer cell fluorescence imaging and PDT.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Oncology
Robert E. Hurst, Paul J. Hauser, Youngjae You, Lora C. Bailey-Downs, Anja Bastian, Stephen M. Matthews, Jessica Thorpe, Christine Earle, Lilly Y. W. Bourguignon, Michael A. Ihnat
Article
Chemistry, Organic
Dominic K. Muli, Pallavi Rajaputra, Youngjae You, Dominic V. McGrath
TETRAHEDRON LETTERS
(2015)
Article
Biochemistry & Molecular Biology
Pallavi Rajaputra, Moses Bio, Gregory Nkepang, Pritam Thapa, Sukyung Woo, Youngjae You
BIOORGANIC & MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Moses Bio, Pallavi Rajaputra, Youngjae You
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Chemistry, Medicinal
Pritam Thapa, Mengjie Li, Moses Bio, Pallavi Rajaputra, Gregory Nkepang, Yajing Sun, Sukyung Woo, Youngjae You
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Pharmacology & Pharmacy
Mengjie Li, Pritam Thapa, Pallavi Rajaputra, Moses Bio, Cody J. Peer, William D. Figg, Youngjae You, Sukyung Woo
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
(2017)
Article
Chemistry, Medicinal
Moses Bio, Kazi Md Mahabubur, Irene Lim, Pallavi Rajaputra, Robert E. Hurst, Youngjae You
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Multidisciplinary
Mengjie Li, Luong Nguyen, Bharathiraja Subramaniyan, Moses Bio, Cody J. Peer, Jessica Kindrick, William D. Figg, Sukyung Woo, Youngjae You
JOURNAL OF CONTROLLED RELEASE
(2019)
Article
Biochemistry & Molecular Biology
Bharathiraja Subramaniyan, Pallavi Rajaputra, Luong Nguyen, Mengjie Li, Cody J. Peer, Jessica Kindrick, William D. Figg, Sukyung Woo, Youngjae You
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2020)
Editorial Material
Biochemistry & Molecular Biology
Martin J. Schnermann, Youngjae You
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luong Nguyen, Daniel C. Schultz, Simon S. Terzyan, Mohammad Rezaei, Jinhua Songb, Chenglong Li, Youngjae You, Marie H. Hanigan
Summary: This study presents the crystal structure of human GGT1 bound with ABBA and the design and synthesis of novel ABBA analogs, providing new insights into the critical role of protein structure dynamics in developing compounds for inhibition of hGGT1.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Ganesh Bist, Nguyen T. Luong, Kazi Md Mahabubur Rahman, Donna M. Ruszaj, Chenglong Li, Marie H. Hanigan, Youngjae You
Summary: In this study, LABBA analogs were synthesized and their inhibitory effect on GGT1 hydrolysis and transpeptidase activity was investigated. The results showed that alpha-COO- and alpha-NH3+ groups, as well as a two-CH2 unit distance between alpha-C and boronic acid, are essential for the activity. L-ABBA was found to be the most potent inhibitor among the analogs. Additionally, L-ABBA was found to significantly reduce plasma cysteine levels and enhance GSH levels.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Simon S. Terzyan, Luong T. Nguyen, Anthony W. G. Burgett, Annie Heroux, Clyde A. Smith, Youngjae You, Marie H. Hanigan
Summary: This study elucidated the crystal structures of human GGT1, revealing the molecular mechanism of substrate binding and cleavage, which will aid in the design of clinically useful GGT1 inhibitors.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Pritam Thapa, Mengjie Li, Radha Karki, Moses Bio, Pallavi Rajaputra, Gregory Nkepang, Sukyung Woo, Youngjae You
Article
Chemistry, Multidisciplinary
Moses Bio, Pallavi Rajaputra, Irene Lim, Pritam Thapa, Bomaonye Tienabeso, Robert E. Hurst, Youngjae You
CHEMICAL COMMUNICATIONS
(2017)