期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 20, 期 3, 页码 1213-1221出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.12.047
关键词
Dengue virus; West Nile virus; Protease; Inhibitor; Click chemistry
资金
- National Institutes of Health [AI082068]
Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed noteworthy inhibitory activity toward Dengue virus NS2B-NS3 protease in the absence and presence of added detergent. These compounds could potentially serve as a launching pad for a hit-to-lead optimization campaign. (C) 2011 Elsevier Ltd. All rights reserved.
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