期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 20, 期 22, 页码 6621-6629出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2012.09.039
关键词
Boranes; Nucleoside conjugates; Reactive oxygen species (ROS); Neutrophils
资金
- Polish Ministry of Sciences and Higher Education [N405 051 32/3592]
- National Science Centre [N N204 531739]
- Institute of Medical Biology PAS
Methods for the synthesis of adenosine/boron cluster conjugates are proposed and the potential of the obtained derivatives to modulate neutrophil activity, especially reactive oxygen species (ROS) production in vitro, is described. An efficient inhibition of ROS production in activated neutrophils by adenosine modified at the 2'-C and 6-N positions with a para-carborane cluster (C2B10H11) was discovered. The high affinity of the selected compounds for adenosine receptor A(2A) was established. These results are in agreement with the possible involvement of receptor A(2A) in the biological activities of adenosine/boron cluster conjugates. This study extends the range of innovative molecules available for testing as agents affecting inflammatory processes. (C) 2012 Elsevier Ltd. All rights reserved.
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