Article
Engineering, Chemical
Yuxi Feng, Huawen Peng, Qiang Zhao
Summary: By synthesizing a new QBPD monomer and modifying the PEI membrane, the rejection rate and pure water flux of MgCl2 were improved, showing good stability and potential for lithium extraction from salt lakes with high Mg2+/Li+ ratio.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jianying Han, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Yunjiang Feng
Summary: Tuberculosis remains a major global disease with high mortality and morbidity, posing challenges for drug discovery due to drug resistance and long treatment duration. Recent advances in research on anti-TB natural products and their potential molecular targets have provided new insights and may contribute to accelerating TB drug discovery.
NATURAL PRODUCT REPORTS
(2022)
Article
Microbiology
Megha Sodani, Chitra S. Misra, Devashish Rath, Savita Kulkarni
Summary: The rapid emergence of drug resistance has created challenges for the treatment of mycobacterial infections. Alternative treatment approaches, such as CRISPR-Cas systems, are needed due to the slow development of new drugs. This study demonstrates the antimicrobial potential of CRISPR-systems against drug-resistant mycobacterial infections and provides evidence for the sequence-specific targeting of antibiotic-resistant factors.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Angela Mesias-Salazar, Rene S. Rojas, Fernando Carrillo-Hermosilla, Javier Martinez, Antonio Antinolo, Oleksandra S. Trofymchuk, Fabiane M. Nachtigall, Leonardo S. Santos, Constantin G. Daniliuc
Summary: This study presents the synthesis and characterization of a new family of one-component catalysts based on guanidinium salts, which are used for the synthesis of cyclic carbonates. The results demonstrate that these catalysts have good conversion rates and can operate effectively at moderate pressures and temperatures.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Nadine Bongaerts, Zainab Edoo, Ayan A. Abukar, Xiaohu Song, Sebastian Sosa-Carrillo, Sarah Haggenmueller, Juline Savigny, Sophie Gontier, Ariel B. Lindner, Edwin H. Wintermute
Summary: This study develops engineered E. coli as a synthetic biology tool for expressing and screening metabolic targets from Mycobacterium tuberculosis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Dongguang Fan, Bin Wang, Giovanni Stelitano, Karin Savkova, Olga Riabova, Rui Shi, Xiaomei Wu, Laurent R. Chiarelli, Katarina Mikusova, Vadim Makarov, Yu Lu, Yuzhi Hong, Chunhua Qiao
Summary: Compound 37, an analogue of benzothiazinone (BTZ), inhibits the essential enzyme DprE1 and shows improved solubility and bioavailability compared to the lead compound. It exhibits bactericidal activity against Mycobacterium tuberculosis (Mtb) in an acute infection mouse model.
Review
Chemistry, Medicinal
Tejas M. Dhameliya, Drashtiben D. Vekariya, Heta Y. Patel, Janvi T. Patel
Summary: As one of the deadliest diseases and the second most common infectious cause of death, tuberculosis poses a severe threat to global health. The development of novel anti-TB scaffolds has been driven by the extended duration of therapy due to resistance and its rise in immunocompromised patients. This study compiles and updates the information on anti-mycobacterial scaffolds published from 2015 to 2020, with a focus on the insights, mechanism of action, and structure-activity relationships of anti-TB agents reported in 2022, providing valuable information for the design of newer anti-TB drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Saurabh Garg, Rakesh Kumar, Dennis Kunimoto, Gina R. Rayat
Summary: This study evaluated the effectiveness of compounds 1-3 as anti-TB agents and found that compound 3 showed the strongest inhibitory effect against M. tuberculosis and M. avium. When combined with isoniazid or rifampicin, compounds 1-3 exhibited additive to synergistic interactions. Additionally, they also demonstrated synergistic effects when combined with certain other anti-TB drugs.
Article
Chemistry, Organic
Zhenzhen Lai, Silei Bai, Aimin Li, Xinxin Feng, Qing He
Summary: Despite significant advances in biomaterials, there is still a need for the development of new materials and strategies for anti-cancer and antimicrobial drug discovery. In this study, the synthesis of two compounds, 1 and 2, was detailed, which showed a strong affinity for guanidinium cations. The ability of these compounds to extract guanidinium cations and their promotion of anti-cancer and antimicrobial activities were demonstrated through various experiments and calculations.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Zhenzhen Lai, Silei Bai, Aimin Li, Xinxin Feng, Qing He
Summary: This study demonstrates the synthesis of two macrocyclic compounds that can complex with guanidinium cations, leading to enhanced anti-cancer and antimicrobial activities. This provides insights into drug discovery in a supramolecular manner.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Subrata Patra, Vinod P. Boricha, Parimal Paul
Summary: A series of metallo-receptors containing ruthenium(II) bipyridine moiety as signaling unit and calix[4]arene coupled with azacrown as ionophore have been synthesized and characterized. These receptors exhibit metal to ligand charge transfer and luminescence properties. The binding constants and ion-binding properties of these receptors have been studied using various metal ions and anions.
INORGANICA CHIMICA ACTA
(2022)
Review
Microbiology
Zane T. Laughlin, Graeme L. Conn
Summary: This article briefly introduces the structures, biosynthesis, and applications of tuberactinomycins in the treatment of tuberculosis. Recent studies on their action on the ribosome and resistance mechanisms are also discussed. Finally, future applications of these drugs are considered after their removal from the List of Essential Medicines.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Uday S. Ganapathy, Tian Lan, Veronique Dartois, Courtney C. Aldrich, Thomas Dick
Summary: The study found that by optimizing the design of analogs, the potency against Mycobacterium abscessus can be improved. These analogs are significantly more potent than rifabutin against major NTM pathogens expressing Arr, providing a powerful medicinal chemistry approach to expand the antimycobacterial spectrum of rifamycins.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Uday S. Ganapathy, Tian Lan, Veronique Dartois, Courtney C. Aldrich, Thomas Dick
Summary: The clinical utility of rifamycins against non-tuberculous mycobacterial disease is limited by drug resistance achieved by ADP-ribosyltransferase. However, a chemically modified rifamycin has been developed with improved potency, providing a potential approach to expand the antimycobacterial spectrum.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Rafael Baptista, Sumana Bhowmick, Jianying Shen, Luis A. J. Mur
Summary: In this study, a molecular reverse docking approach was used to predict interactions between 53 selected anti-mycobacterial natural products and known druggable mycobacterial targets. Results showed that certain compounds had significantly higher binding free energies against PknB and DprE1 targets, suggesting their potential use in drug optimization research.
Article
Biochemistry & Molecular Biology
Hugues Massimba-Dibama, Maxime Mourer, Patricia Constant, Mamadou Daffe, Jean-Bernard Regnouf-de-Vains
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Chemistry, Medicinal
Aurelien Chollet, Giorgia Mori, Christophe Menendez, Frederic Rodriguez, Isabelle Fabing, Maria Rosalia Pasca, Jan Madacki, Jana Kordulakova, Patricia Constant, Annaik Quemard, Vania Bernardes-Genisson, Christian Lherbet, Michel Baltas
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Nawel Slama, Stevie Jamet, Wafa Frigui, Alexandre Pawlik, Daria Bottai, Francoise Laval, Patricia Constant, Anne Lemassu, Kaymeuang Cam, Mamadou Daffe, Roland Brosch, Nathalie Eynard, Annaik Quemard
MOLECULAR MICROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Ainhoa Arbues, Wladimir Malaga, Patricia Constant, Christophe Guilhot, Jacques Prandi, Catherine Astarie-Dequeker
ACS CHEMICAL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Aurelien Chollet, Jean-Luc Stigliani, Maria Rosalia Pasca, Giorgia Mori, Christian Lherbet, Patricia Constant, Annaik Quemard, Jean Bernadou, Genevieve Pratviel, Vania Bernardes-Genisson
CHEMICAL BIOLOGY & DRUG DESIGN
(2016)
Article
Multidisciplinary Sciences
Pedro Moura-Alves, Kellen Fae, Erica Houthuys, Anca Dorhoi, Annika Kreuchwig, Jens Furkert, Nicola Barison, Anne Diehl, Antje Munder, Patricia Constant, Tatsiana Skrahina, Ute Guhlich-Bornhof, Marion Klemm, Anne-Britta Koehler, Silke Bandermann, Christian Goosmann, Hans-Joachim Mollenkopf, Robert Hurwitz, Volker Brinkmann, Simon Fillatreau, Mamadou Daffe, Burkhard Tuemmler, Michael Kolbe, Hartmut Oschkinat, Gerd Krause, Stefan H. E. Kaufmann
Article
Multidisciplinary Sciences
Roxane Simeone, Gaelle Huet, Patricia Constant, Wladimir Malaga, Anne Lemassu, Francoise Laval, Mamadou Daffe, Christophe Guilhot, Christian Chalut
Article
Biochemistry & Molecular Biology
Maxime Mourer, Raphael E. Duval, Patricia Constant, Mamadou Daffe, Jean-Bernard Regnouf-de-Vains
Article
Microbiology
Sheng Zeng, Patricia Constant, Dong Yang, Alain Baulard, Philippe Lefevre, Mamadou Daffe, Ruddy Wattiez, Veronique Fontaine
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Cyril Lefebvre, Wafa Frigui, Nawel Slama, Francoise Lauzeral-Vizcaino, Patricia Constant, Anne Lemassu, Tanya Parish, Nathalie Eynard, Mamadou Daffe, Roland Brosch, Annaik Quemard
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Celia de Sousa-d'Auria, Florence Constantinesco-Becker, Patricia Constant, Maryelle Tropis, Christine Houssin
Article
Microbiology
Gopinath Krishnamoorthy, Peggy Kaiser, Patricia Constant, Ulrike Abu Abed, Monika Schmid, Christian K. Frese, Volker Brinkmann, Mamadou Daffe, Stefan H. E. Kaufmann
Summary: Mycofactocin, a peptide-derived redox cofactor, is found in certain bacteria like Mycobacterium tuberculosis. Research indicates that mftD gene expression is upregulated in hypoxia-adapted M. tuberculosis, but its functionality may not be essential for L-lactate metabolism. The study highlights the potential significance of mycofactocin in bacterial growth and persistence within the host.
Article
Microbiology
Celia de Sousa-d'Auria, Florence Constantinesco, Nicolas Bayan, Patricia Constant, Maryelle Tropis, Mamadou Daffe, Marc Graille, Christine Houssin
Summary: Mycolic acids are essential components of the cell envelope in Corynebacteriales, particularly in Mycobacterium tuberculosis. In this study, the researchers identified a new protein (Cg1246) involved in mycolic acid metabolism using mutagenesis. They characterized the functional and structural properties of Cg1246 and found that its absence led to a decrease in the pool of trehalose monomycolate (TMM), resulting in a reduction in other mycolate-containing compounds. Interestingly, the researchers discovered that the phosphatase activity of Cg1246 was not involved in mycolic acid biosynthesis.
Article
Biochemistry & Molecular Biology
Nguyen-Hung Le, Patricia Constant, Samuel Tranier, Virginie Nahoum, Valerie Guillet, Laurent Maveyraud, Mamadou Daffe, Lionel Mourey, Pierre Verhaeghe, Hedia Marrakchi
Summary: Tuberculosis is a global health crisis with limited treatment options and drug resistance issues. Developing drugs targeting enzymes involved in cell envelope synthesis of Mycobacterium tuberculosis is crucial. Through a drug repurposing campaign, salicylanilide closantel and its derivatives were discovered as potential candidates for novel anti-tubercular drugs.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)