Article
Medicine, General & Internal
Seok Hui Kang, Bo Yeon Kim, Eun Jung Son, Gui Ok Kim, Jun Young Do
Summary: This study aimed to evaluate patient survival with the use of renin-angiotensin system blockers (RASBs) in maintenance hemodialysis (HD) patients, and found that the use of RASBs was associated with higher patient survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Annina S. Vischer, Gabriela M. Kuster, Raphael Twerenbold, Otmar Pfister, Qian Zhou, Andrea Villiger, Marko Poglitsch, Stephan Krahenbuhl, Michael Mayr, Stefan Osswald, Manuel Haschke, Thilo Burkard
Summary: Different antihypertensive drugs have significant effects on angiotensin II and Ang (1-7) concentrations, with perindopril and olmesartan showing distinct alterations favoring the anti-inflammatory axis.
Review
Pharmacology & Pharmacy
Persoulla A. Nicolaou
Summary: Sex-related differences in clinical manifestations, risk factors, and treatment drug use in patients with heart failure are significant, particularly in the regulation of the renin-angiotensin-aldosterone system (RAAS). While current evidence suggests potential differences in the efficacy of RAAS drugs between men and women, further research is needed to determine the optimal treatment strategies for both genders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Piotr Jedrusik, Bartosz Symonides, Jacek Lewandowski, Zbigniew Gaciong
Summary: Primary aldosteronism (PA) is a potentially curable form of secondary hypertension that requires measuring renin and aldosterone, followed by confirmatory tests. Various antihypertensive drug classes interfere with PA evaluation, with calcium antagonists and alpha-blockers being the least interfering drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kung-Ming Laio, Chuan-Wei Shen, Yun-Hui Huang, Chun-Hui Lu, Hsuan-Lin Lai, Chung-Yu Chen
Summary: The prescription pattern and effectiveness of antihypertensive drugs in surgical patients with aortic dissection were investigated. The study found that no specific type of antihypertensive drug was associated with a better outcome in patients with type A aortic dissection, while the use of beta-blockers and calcium channel blockers (CCBs) was related to a significantly lower risk of the composite outcome in patients with type B aortic dissection.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Article
Multidisciplinary Sciences
Jihei Sara Lee, Hye Ryeong Cha, Hyoung Won Bae, Sang Yeop Lee, Wungrak Choi, Seung Won Lee, Chan Yun Kim
Summary: The purpose of this study was to investigate the effect of antihypertensive medication on the risk of open-angle glaucoma (OAG) in patients diagnosed with hypertension. The study found that certain antihypertensive medications slightly increased the risk of OAG, but the effects were small. Further research is needed to understand the associations between hypertension, medication, therapeutic effect, and OAG.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Kengo Azushima, Jean -Paul Kovalik, Takahiro Yamaji, Jianhong Ching, Tze Wei Chng, Jing Guo, Jian-Jun Liu, Mien Nguyen, Rashidah Binte Sakban, Simi E. George, Puay Hoon Tan, Su Chi Lim, Susan B. Gurley, Thomas M. Coffman
Summary: This study found that in a mouse model of diabetic nephropathy, there were elevated lactate levels and impaired energy metabolism in the kidneys. Treatment with an angiotensin-receptor blocker (ARB) improved these abnormalities. Increased expression of lactate dehydrogenase isoforms, specifically LdhA in the proximal tubule, was also observed. Urinary lactate levels were found to be predictive of clinical outcomes in diabetic patients with kidney disease.
KIDNEY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Sam Siljee, Bridget Milne, Helen D. Brasch, Nicholas Bockett, Josie Patel, Paul F. Davis, Andrew Kennedy-Smith, Tinte Itinteang, Swee T. Tan
Summary: This study demonstrated the expression of PRR, ACE2, and AT(2)R by the CSCs within RCCC. Further studies may lead to novel therapeutic targeting of CSCs by manipulation of the RAS in the treatment of this aggressive cancer.
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Wanessa M. C. Awata, Arthur H. Sousa, Marcela M. B. de Mello, Thales M. H. Dourado, Lucas C. Pinheiro, Jefferson Elias-Oliveira, Vanessa F. Rodrigues, Daniela Carlos, Michele M. Castro, Carlos R. Tirapelli
Summary: Ethanol consumption leads to dysfunction of perivascular adipose tissue (PVAT) through the activation of the renin-angiotensin-aldosterone system (RAAS), particularly through the involvement of angiotensin II type 1 receptors (AT1R). This dysfunction involves reductions in the production of adiponectin and nitric oxide, resulting in impaired vasodilation and increased vascular contraction. These findings suggest that PVAT dysfunction may contribute to the hypertensive effects associated with ethanol consumption.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chan Soon Park, Han-Mo Yang, Jeehoon Kang, Jung-Kyu Han, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Ki-Bae Seung, Kwang Soo Cha, In-Whan Seong, Seung-Woon Rha, Myung Ho Jeong, Hyo-Soo Kim, KAMIR-NIH Registry
Summary: The use of Renin-angiotensin-system inhibitors (RASi) medication at 1-year follow-up did not show any improvement in 2-year all-cause mortality or cardiac mortality for patients after acute myocardial infarction (MI). This study provides valuable information for tailored medication strategies after acute MI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Sheng Wei Lo, Jonathan P. P. Segal, John S. S. Lubel, Mayur Garg
Summary: This review summarizes the current understanding of the physiological mechanism of the renin-angiotensin system in inflammatory bowel disease and explores its potential therapeutic implications.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Review
Peripheral Vascular Disease
Alimamy Umaru Kabia, Ping Li, Zhichao Jin, Xiaojie Tan, Yilong Liu, Yuqi Feng, Keyao Yu, Ming Hu, Dongming Jiang, Guangwen Cao
Summary: This study found that COVID-19 patients with hypertension are at increased risk of in-hospital mortality and other adverse outcomes, with variations observed across different age groups. ACEI/ARB treatments do not increase the in-hospital mortality of patients with hypertension.
JOURNAL OF HYPERTENSION
(2022)
Review
Peripheral Vascular Disease
Yasushi Matsuzawa, Kazuo Kimura, Hisao Ogawa, Kouichi Tamura
Summary: This article summarizes the potential effects of RAS inhibitors and their impact on COVID-19, indicating that further research is needed to confirm their role.
HYPERTENSION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gaurangkumar C. Brahmbhatt, Tushar R. Sutariya, Hiralben D. Atara, Narsidas J. Parmar, Vivek K. Gupta, Irene Lagunes, Jose M. Padron, Prashant R. Murumkar, Mange Ram Yadav
MOLECULAR DIVERSITY
(2020)
Review
Pharmacology & Pharmacy
Prashant R. Murumkar, Rahul B. Ghuge, Monica Chauhan, Rahul R. Barot, Sharmishtha Sorathiya, Kailash M. Choudhary, Karan D. Joshi, Mange Ram Yadav
EXPERT OPINION ON DRUG DISCOVERY
(2020)
Article
Biochemistry & Molecular Biology
Ashish M. Kanhed, Dushyant Patel, Divya M. Teli, Nirav R. Patel, Mahesh T. Chhabria, Mange Ram Yadav
Summary: COVID-19 is a worldwide pandemic caused by the novel coronavirus, requiring structural and non-structural proteins for replication mainly by the main protease (Mpro). Systematic screening of approved drug library and Asinex BioDesign library identified potential antiviral agents, with structural modifications needed for stability and safety.Screenings of the libraries resulted in molecules with promising interactions with the target protein Mpro, categorized into different classes for further drug development.
MOLECULAR DIVERSITY
(2021)
Article
Biochemistry & Molecular Biology
Dushyant Patel, Nirav R. Patel, Ashish M. Kanhed, Divya M. Teli, Kishan B. Patel, Pallav M. Gandhi, Sagar P. Patel, Bharat N. Chaudhary, Dharti B. Shah, Navnit K. Prajapati, Kirti Patel, Mange Ram Yadav
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Kishan B. Patel, Dushyant Patel, Nirav R. Patel, Ashish M. Kanhed, Divya M. Teli, Bhumi Gandhi, Bhavik S. Shah, Bharat N. Chaudhary, Navnit K. Prajapati, Kirti Patel, Mange Ram Yadav
Summary: Carbazole-based derivatives were designed, synthesized, and evaluated for their inhibitory activity against cholinesterase, antioxidant properties, and metal chelating abilities. Two compounds showed promising ChE inhibitory activity and specific copper ion chelating ability, along with strong interactions with the active sites of ChE enzymes. These compounds also demonstrated significant in silico drug-like pharmacokinetic properties.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Gurprit Bhardwaj, Mitul Vakani, Abhay Srivastava, Dhaval Patel, Anju Pappachan, Prashant Murumkar, Hemal Shah, Rushabh Shah, Sarita Gupta
Summary: Swertisin effectively lowers blood glucose levels by inhibiting SGLT2 and reducing its expression, leading to improved glucose homeostasis in diabetic mice.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Honnavalli Yogish Kumar, Prashant R. Murumkar, B. P. Srinivasan, Vijay Pawar, M. R. Yadav
Summary: This study reported the design, synthesis, and cytotoxicity studies of a series of derivatives, with two compounds showing remarkable cytotoxicity and inducing cell cycle arrest and apoptosis in leukemia cancer cells.
MOLECULAR DIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
M. R. Suryawanshi, A. M. Kanhed, V. M. Kulkarni, S. H. Bhosale, M. R. Yadav
Summary: In this study, a hit molecule with antidepressant activity was discovered and modified chemically to obtain different derivatives. The synthesized compounds showed moderate to good antidepressant activity, with the most potent compound exhibiting better potential than standard drugs. Molecular dynamics and acute oral toxicity tests were also performed.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Multidisciplinary
Mange Ram Yadav, Mukesh Kumar, Prashant R. Murumkar
Summary: Gene therapy has the potential to address a wide range of health issues, but the lack of a suitable vector is a major obstacle. Gemini amphiphiles show promise in transfection efficiency, although they exhibit concentration-dependent toxicity in MTT assays.
Review
Chemistry, Medicinal
Prashant R. Murumkar, Mayank Kumar Sharma, Pradeep Gupta, Niyati M. Patel, Mange Ram Yadav
Summary: The selection of the right protein structure is crucial for the success of drug discovery through structure-based design. This study presents a systematic approach for choosing the appropriate type of protein structure, with case studies on TACE, 11 beta-HSD1, DprE1, and SARS-CoV-2 M-pro enzymes for illustration.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Kaushik Neogi, Prashant R. Murumkar, Priyanshu Sharma, Poonam Yadav, Mallika Tewari, Devarajan Karunagaran, Prasanta Kumar Nayak, Mange Ram Yadav
Summary: In this study, novel 4,7-disubstituted 8-methoxyquinazoline derivatives were designed as potential cytotoxic agents against cancers by inhibiting the protein-protein interactions of beta-catenin/TCF4. The most potent compound (18B) showed significant cytotoxicity, inducing apoptosis and inhibiting cell migration in HCT116 and HepG2 cells. Mechanistic studies revealed that compound (18B) downregulated the beta-catenin/TCF4 signaling pathway, protein expression, and mRNA levels of c-MYC andCyclin D1. It also exhibited cytotoxicity against primary human gallbladder cancer cells. These findings suggest that compound (18B) is a promising lead molecule for anticancer therapy targeting the beta-catenin/TCF4 signaling pathway.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Chemistry, Physical
Drishti Panjwani, Shruti Patel, Deepak Mishra, Viral Patel, MangeRam Yadav, Abhay Dharamsi, Asha Patel
Summary: This study developed and characterized biotin-streptavidin conjugated bovine serum albumin nanoparticles containing Gefitinib using the desolvation method. The nanoparticles exhibited monodispersity and a negatively charged surface. They showed high drug loading and sustained drug release at physiological pH. In cytotoxicity studies, these nanoparticles demonstrated better cell growth inhibition and reduced side effects compared to other formulations of Gefitinib.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Atul N. Khadse, Hardik H. Savsani, Rupesh V. Chikhale, Rahul B. Ghuge, Dixit R. Prajapati, Goshiya Kureshi, Prashant R. Murumkar, Kirti V. Patel, Sadhana J. Rajput, Mange Ram Yadav
Summary: Direct inhibition of FXa has been proven effective in anticoagulation with minimal bleeding risks. A novel series of anthranilamide derivatives were designed and synthesized to improve selectivity and physicochemical properties. These compounds showed potent FXa inhibitory activities and high selectivity over thrombin, as well as good anticoagulant activity and safety in animal models.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Ashish M. Kanhed, Dushyant V. Patel, Nirav R. Patel, Anshuman Sinha, Priyanka S. Thakor, Kishan B. Patel, Navnit K. Prajapati, Kirti V. Patel, Mange Ram Yadav
Summary: To confront the complex pathogenesis of Alzheimer's disease, the development of multitarget-directed ligands has emerged as a promising approach. In this study, a series of indoloquinoxaline derivatives were designed and synthesized for Alzheimer's disease. The synthesized compounds exhibited moderate to good cholinesterase inhibitory activity and compound 9f was identified as the most potent and selective BuChE inhibitor. Compound 9f also showed self-induced Aβ(1-42) aggregation inhibitory activity and favorable in silico ADMET properties. These findings suggest that compound 9f has potential as a multitarget-directed ligand for developing novel anti-AD drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
