期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 18, 期 5, 页码 1875-1881出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2010.01.043
关键词
Pyrazolines; MAO inhibitors; Molecular docking
资金
- AICTE
3,5-Diaryl pyrazolines analogs were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity. The compounds were found reversible and selective towards MAO-A with selectivity index in the magnitude of 10(3)-10(5). The docking studies were carried out to gain further structural insights of the binding mode and possible interactions with the active site of MAO-A. Interestingly, the theoretical (K-i) values obtained by molecular docking studies were in congruence with their experimental (K-i) values. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据