期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 18, 页码 6692-6698出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.07.072
关键词
Flavonoid derivatives; Synthesis; AChE inhibitor
资金
- National Natural Science Foundation of China [30572239]
- Health Bureau of Zhejiang Province Foundation [WKJ2007-016]
A new series of flavonoid derivatives have been designed, synthesized and evaluated as potent AChE inhibitors. Most of them showed more potent inhibitory activities to AChE than rivastigmine. The most potent inhibitor isoflavone derivative 10d inhibit AChE with a IC50 of 4 nM and showed high BChE/AChE inhibition ratio (4575-fold), superior to donepezil (IC50 = 12 nM, 389-fold). Molecular docking studies were also performed to explore the detailed interaction with AChE. (C) 2009 Elsevier Ltd. All rights reserved.
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