期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 2, 页码 848-854出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.11.036
关键词
Ursolic acid derivatives; Triterpene; Anti-tumor activity
资金
- Natural Science Foundation of Liaoning Province of China [20042009]
- Science and Technology Foundation of Shenyang City of China [20050785]
Nineteen ursolic acid derivatives (15 novel compounds) modified at the C-3 and the C-28 positions were synthesized. The cytotoxic activity of the derivatives was evaluated against HeLa, BGC-823 and SKOV3 cells by MTT assay. Inducing apoptosis and affecting cell cycle distribution by the derivatives in HeLa cells were assessed by flow cytometry and DNA fragmentation. Compounds 10b and 11b were particularly active to inhibit HeLa cells growth through inducing apoptosis and arresting cell cycle progression. The typical 'sub-G1 peak' and DNA ladder formation were checked and cell cycle was arrested at the S phase in a dose-dependent manner. (C) 2008 Elsevier Ltd. All rights reserved.
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