Article
Biochemistry & Molecular Biology
Yudong Yin, Li Sun, Lixin Sheng, Liqiong Zhang, Jingjing Liu, Xiaoan Wen, Weibin Mo, Quande Wang, Keguang Cheng
Summary: To discover more effective and less toxic drugs in anti-tumor field, the backbone structure of 17/?-estradiol was modified and 11 target compounds were synthesized. Compounds 5 and 10 showed better anti-tumor activity and higher selectivity, inducing apoptosis in MCF-7 cells and binding to estradiol receptor alpha. They also upregulated the expression of apoptosis-related factors and downregulated anti-apoptotic factors, indicating the induction of cell death through both endogenous and exogenous pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Barbara Toffoli, Federica Tonon, Veronica Tisato, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi
Summary: TRAIL induces apoptosis in cancer cells, while its effects in normal cells remain unclear. Studies have shown that TRAIL treatment reduces weight gain, insulin resistance, and inflammation in high-fat diet mice, and promotes skeletal muscle free fatty acid oxidation. Both in vitro and in vivo data demonstrate that TRAIL enhances AKT phosphorylation, skeletal muscle differentiation, and glucose uptake, suggesting therapeutic potential for metabolic disturbances and muscle mass loss associated with diabetes.
CELL DEATH & DISEASE
(2021)
Article
Biology
Dongjin Jeong, Hye Sung Kim, Hye Young Kim, Min Jueng Kang, Hyeryeon Jung, Yumi Oh, Donghyun Kim, Jaemoon Koh, Sung-Yup Cho, Yoon Kyung Jeon, Eun Bong Lee, Seung Hyo Lee, Eui-Cheol Shin, Ho Min Kim, Eugene C. Yi, Doo Hyun Chung
Summary: This study shows that sFasL interacts with DR5 to promote inflammation, potentially enhancing it through the CX3CL1-CX3CR1 axis. The interaction plays a role in autoantibody-induced arthritis, possibly mediated through the NF-kappa B pathway.
Article
Pharmacology & Pharmacy
Danyang Zhao, Lei Yang, Peng Han, Haihui Zhang, Fanjun Wang, Zhiyun Meng, Hui Gan, Zhuona Wu, Wenzhong Sun, Chuan Chen, Guifang Dou, Ruolan Gu
Summary: This study found that soluble death receptor 5 fusion protein (sDR5-Fc) effectively inhibited excessive apoptosis in radiation-sensitive tissues and mitigated radiation-induced damage. It also improved abnormal biochemical indicators, regulated immune cell numbers, and reduced blood cell death. In vitro experiments showed that sDR5-Fc effectively inhibited apoptosis of human intestinal mucosal epithelial cells and IEC-6 cells. Survival studies demonstrated that sDR5-Fc administration significantly increased the 30-day survival of mice after whole body radiation. These findings suggest that the DR5-mediated apoptosis pathway plays a crucial role in ARS injury and that DR5 may be a potential therapeutic target. sDR5-Fc, as a DR5 apoptosis antagonist, may be a promising anti-ARS drug candidate deserving further investigation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Suchanoot Kutpruek, Kanchana Suksri, Petcharee Maneethorn, Namoiy Semprasert, Pa-thai Yenchitsomanus, Suwattanee Kooptiwut
Summary: Our study demonstrates that dexamethasone induces pancreatic beta-cell apoptosis by upregulating TRAIL and DR5 expression, while imatinib can protect against it by reducing their expression. This finding is significant in preventing steroid-induced diabetes.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Haojie Li, Junjiang Fan, Yangfei Zhao, Jiarong Yang, Huimiao Xu, Ram Kumar Manthari, Xiaofang Cheng, Jundong Wang, Jinming Wang
Summary: The study shows that long-term excessive intake of fluoride can cause kidney damage and apoptosis, while dietary calcium supplementation can alleviate this damage. Calcium supplementation mitigates fluoride-induced kidney apoptosis through various signaling pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Liang Ma, Hong-Ling Wei, Ke-Jie Wang, Xiang-Yu Meng, Sai-Qi Ni, Cheng Zhou, Yi Li, Rui Yu, Qi Ma
Summary: This study found that the combination of rhein (RH) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can inhibit the proliferation and induce apoptosis of bladder cancer cells, suggesting its potential value in clinical treatment.
Article
Medicine, Research & Experimental
Ya-jun Hou, Dawei Li, Weiqi Wang, Leilei Mao, Xiaoyan Fu, Baoliang Sun, Cundong Fan
Summary: This study evaluated the anticancer effects and mechanism of NT157 against human glioma growth, and found that NT157 alone inhibited glioma cell growth by regulating cell cycle, promoting apoptosis, and inducing DNA damage and dysfunction of signaling pathways. Combined treatment with TRAIL further enhanced apoptosis by upregulating DR5 and inducing DNA damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Longfei Deng, Xuan Zhai, Ping Liang, Hongjuan Cui
Summary: TRAIL holds therapeutic potential in cancer treatment, but many cancers, including GBM, exhibit resistance. Recent studies have identified new mechanisms in regulating TRAIL-induced apoptosis in GBM and effective combinatorial strategies. The TRAIL/TRAIL death receptor axis may have future clinical applications for GBM treatment.
Article
Cell Biology
Emir Bozkurt, Heiko Dussmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn
Summary: The study reveals that TRAIL signaling not only activates apoptosis in colon cancer cells but also induces entosis through TRAIL receptors and the structural presence of caspase-8. The association of TRAIL signaling with cell-in-cell structures is significant in colorectal cancer, especially in the context of patient prognosis. Factors controlling entosis in tumors remain to be elucidated despite the evidence of entosis in cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Chen, Miao Hao, Jingmin Yan, Lin Sun, Guihua Tai, Hairong Cheng, Yifa Zhou
Summary: The active compound DHCP isolated from heat-treated citrus pectin induces cell death in colon cancer cells by inducing mitochondrial ROS, enhances cancer cells sensitivity to TRAIL, and synergistically inhibits the growth of HCT116 and HT-29 xenografts. Furthermore, DHCP increases DR5 expression to further inhibit tumor growth.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anne Yagolovich, Alina A. Isakova, Artem A. Artykov, Yekaterina V. Vorontsova, Diana Mazur, Nadezhda Antipova, Marat S. Pavlyukov, Mikhail Shakhparonov, Anastasia M. Gileva, Elena A. Markvicheva, Ekaterina A. Plotnikova, Andrey A. Pankratov, Mikhail P. Kirpichnikov, Marine E. Gasparian, Dmitry A. Dolgikh
Summary: In this study, the antitumor activity of DR5-B was improved by fusion with a tumor-homing iRGD peptide, resulting in a promising candidate for targeted therapy for glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hyeonwoo Je, Gi-Hoon Nam, Gi Beom Kim, Wonjun Kim, Soo Rin Kim, In-San Kim, Eun Jung Lee
Summary: TRAIL shows promising anti-tumor activity, but faces challenges such as resistance and delivery issues. A nanocage has been developed to efficiently deliver TRAIL and a re-sensitizing drug (DOX) to overcome TRAIL-resistant tumors, demonstrating potential as an effective antitumor agent.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Dermatology
Pengfei Sun, Zhensheng Hu, Bo Pan, Xiaosheng Lu
Summary: Keloid is a common disease in plastic surgery, with poor treatment effects using methods such as drug injection, surgical resection, cryotherapy, and laser treatment. The discovery of TRAIL in 1995 has led to its potential use in targeting tumors, and recent research has shown its potential in treating keloids by inducing fibroblast apoptosis through TRAI binding to its receptor.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Review
Oncology
Julio M. Pimentel, Jun-Ying Zhou, Gen Sheng Wu
Summary: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising agent for cancer therapy due to its selective induction of apoptosis in tumor cells without harming normal cells. However, the efficacy of TRAIL-based therapies in clinical trials is limited. In addition to its role in cancer cell apoptosis, TRAIL also plays a critical role in tumor immunosurveillance and may interact with immune checkpoint proteins, such as programmed death-ligand 1 (PD-L1), to modulate PD-L1-based tumor immunotherapies. This review discusses recent findings on TRAIL-based therapy, resistance, and its involvement in tumor immunosurveillance.
Article
Chemistry, Medicinal
Yasumasa Hara, Yuichi Totsugi, Hiroshi Ichikawa, Shinji Harada, Kazuki Fujii, Firoj Ahmed, Samir K. Sadhu, Midori A. Arai, Masami Ishibashi
Summary: Acacienone (1), a novel C20 natural product, was isolated from the leaves of Acacia mangium collected in Bangladesh. The compound's structure was determined by spectral studies and X-ray crystallographic analysis, revealing unique terpenoid-related features.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biotechnology & Applied Microbiology
Midori A. Arai, Itsuki Ebihara, Yoshinori Makita, Yasumasa Hara, Takashi Yaguchi, Masami Ishibashi
Summary: In this study, Notch signaling inhibitors were identified from extracts of Nocardia sp., with compound 1 and compound 2 showing Notch inhibitory activities. These compounds also exhibited cytotoxicity against a mouse macrophage-like cell line. The results suggest that production of Notch inhibitors by pathogenic bacteria may enhance pathogen infectivity.
JOURNAL OF ANTIBIOTICS
(2021)
Article
Chemistry, Applied
Masaru Kondo, Naoki Matsuyama, Tin Z. Aye, Irshad Mattan, Tomoyuki Sato, Yoshinori Makita, Masami Ishibashi, Midori A. Arai, Shinobu Takizawa, Hiroaki Sasai
Summary: A stereoselective synthetic route to chiral C3-spirooxindole- and C2-spiropseudoindoxyl-pyrrolidines was successfully achieved by an enantioselective organocatalyzed Pictet-Spengler reaction followed by a diastereoselective oxidative rearrangement. The prepared enantioenriched spiro compounds demonstrated moderate activities in a Wnt signaling inhibitory assay. Eco-friendly oxidants were used in the process, enabling rapid access to the chiral compounds.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Yasumasa Hara, Daiki Tanimura, Teruhisa Manome, Midori A. Arai, Takashi Yaguchi, Masami Ishibashi
Summary: In this study, two peptidolipin NA derivatives were isolated from the co-culture of Nocardia arthritidis IFM10035(T) and the mouse macrophage cell line J774.1. These compounds showed higher cytotoxicity against J774.1 cells and displayed TRAIL-resistance-overcoming activity in human gastric adenocarcinoma AGS cells.
Article
Chemistry, Medicinal
Teruhisa Manome, Yasumasa Hara, Firoj Ahmed, Samir K. Sadhu, Masami Ishibashi
Summary: Two new compounds were isolated from Terminalia bellirica leaves and their structures were determined. Among them, corilagin exhibited cytotoxicity against gastric cancer cells and beta-d-glucopyranose trigallate showed the ability to overcome TRAIL resistance.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Medicinal
Kritamorn Jitrangsri, Kazuaki Kamata, Mana Akiba, Yoshie Yajiri, Masami Ishibashi, Jin Tatsuzaki, Tsutomu Ishikawa
Summary: This study improved the preparation method of 18α-glycyrrhizin from 18β-glycyrrhizin and provided evidence for the natural existence of 18α-glycyrrhizin in Glycyrrhiza species.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Medicinal
Yoshinori Makita, Shun Saito, Anna Tsuchiya, Masami Ishibashi, Midori A. Arai
Summary: Notch signaling pathway is crucial in cell differentiation and proliferation, but abnormal activation can lead to tumorigenesis. Compound 1 beta,2 alpha-epoxytagitinin C (2) was discovered to inhibit Notch signaling and exhibit strong cytotoxicity against the Notch-activated leukemia cell line HPB-ALL.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Organic
Yasumasa Hara, Keiichiro Watanabe, Akiko Takaya, Teruhisa Manome, Takashi Yaguchi, Masami Ishibashi
Summary: Two new peptides named uniformides A and B (1 and 2) were isolated from the cultured extracts of Nocardia uniformis IFM0856(T) in the presence of mouse macrophage-like cell line J774.1, showing high cytotoxicity against J774.1 and inhibiting the production of nitric oxide, IL-6, and IL-1 beta through the suppression of the NF-kappa B pathway. These compounds were only produced in cultures containing J774.1.
Correction
Chemistry, Organic
Yasumasa Hara, Keiichiro Watanabe, Akiko Takaya, Itsuki Ebihara, Teruhisa Manome, Midori A. Arai, Takashi Yaguchi, Masami Ishibashi
Article
Chemistry, Medicinal
Teruhisa Manome, Yasumasa Hara, Masami Ishibashi
Summary: A new 1,2-diketone physalin, physalin XII (1), and 13 known compounds were isolated from Physalis minima whole plant collected in Thailand. Among them, physalin F (3) showed the strongest activity against TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Teruhisa Manome, Yasumasa Hara, Masami Ishibashi
Summary: Eighteen compounds, including fourteen flavonoids, one steroid, two fatty acids, and one nitrogen-containing compound, were isolated from the whole Blumea lacera plant collected in Thailand. Compounds 1-11 and 15-17 showed activity in overcoming tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance. Among them, bonanzin (2) and cirsilineol (7) exhibited particularly strong TRAIL resistance-overcoming activity, with IC50 values of 10.7 μM and 5.9 μM, respectively, against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL).
Article
Plant Sciences
Kritamorn Jitrangsri, Yasumasa Hara, Akiko Takaya, Masami Ishibashi
Summary: Bioactivity-guided isolation of Uvaria rufa leaves and Nephelium hypoleucum bark led to the discovery of nine compounds with a new polyoxygenated cyclohexene scaffold. These compounds exhibited TRAIL resistance-overcoming activity and increased inhibition of gastric cancer cell line. Compounds 3 and 9 were found to sensitize AGS cells to apoptosis via both extrinsic and intrinsic pathways.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
Yasumasa Hara, Teruhisa Manome, Wataru Suehiro, Shinji Harada, Yoshikazu Yamagishi, Akiko Takaya, Yasumitsu Ogra, Masami Ishibashi
Summary: Two new octadeca-peptibols, trichorzin PAX and XI (1 and 2), were isolated from the fungus Trichoderma harzianum IFM 66736, obtained from the soil in Aobanomori Park, Chiba City, Japan. The structures of the compounds were determined through spectral studies, X-ray crystallographic analysis, and MS/MS analysis. Compound 1 and 2 exhibited cytotoxicity against human colon cancer cell lines HCT116.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Medicinal
Kazuki Fujii, Yasumasa Hara, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi
Summary: A new coumarin derivative and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata. These compounds exhibited BMI1 promoter inhibitory activity, and one compound showed high cytotoxicity against DU145 cells.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Chemistry, Organic
Yasumasa Hara, Mareno Chiba, Keiichiro Watanabe, Masami Ishibashi
Summary: A new ketone, ikahonone (1), and five known compounds (2-6) were isolated from Bacillus cereus IFM12235 collected in Japan. The structure of compound 1 was elucidated using spectral studies, including NMR. The absolute configurations of 1 and 2 were determined by comparing ECD spectra with known compounds and calculating the ECD spectra of 1 and 2. Additionally, three compounds (2-4) were synthesized previously but first isolated as natural products in this study.
