期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 8, 页码 3142-3151出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.02.059
关键词
Dithiolato Cu(II) complexes; i-MNT, Di-, Tri-amines; Thiazoles; Toxicity; In vitro/in vivo antitumor activity; SCEs; PRI
资金
- Greek General Secretariat for Research and Technology
- European Commission [01ED367]
A series of new mixed-ligand neutral copper(II) complexes of the general type [Cu(amine)(i-MNT)] and [Cu(tz)(i-MNT)] was prepared and characterized by elemental, spectroscopic methods, mu(eff), Lambda(mu) measurements and molecular modeling studies. The acute toxicity, the cytogenetic and the in vivo antitumor activity of the new complexes, is related to their chemical and physicochemical properties. Among the Cu(II) compounds tested the complex with 2-amino-5-methyl thiazole increases significantly the life span of leukemia P388 bearing mice in vivo. (C) 2009 Elsevier Ltd. All rights reserved.
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