Review
Chemistry, Medicinal
Saeed Mohammadian Haftcheshmeh, Maliheh Abedi, Kazem Mashayekhi, Mohammad Javad Mousavi, Jamshid Gholizadeh Navashenaq, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
Summary: This review discusses the modulatory effects of berberine (BBR) on various inflammatory signaling pathways in the immune system and explores its therapeutic efficacy and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Dewei He, Guiqiu Hu, Ang Zhou, Yanting Liu, Bingxu Huang, Yingchun Su, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Shoupeng Fu, Dianfeng Liu
Summary: This study found that Echinocystic acid (EA) inhibits neuroinflammation by activating the PI3K/Akt pathway and inhibiting the NF-kappa B and MAPK pathways, and exhibits neuroprotective effects in vivo and in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Yebin Oh, Hak-Jun Jung, Seungwon Hong, Yerim Cho, Jiyeong Park, Daeho Cho, Tae Sung Kim
Summary: Activation of microglia by AIMP1 through the JNK and p38/NF-kappa B pathways induces neuroinflammation and polarization of microglial cells into the M1 state.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Xue Luan, Zhongcheng Cong, Tassos P. Anastassiades, Yin Gao
Summary: In this study, it was found that N-butyrylated hyaluronic acid (BHA) has anti-inflammatory and antioxidative activities by inhibiting pro-inflammatory cytokines, reducing ROS production, and regulating signaling pathways. BHA alleviated joint swelling, inflammatory cell infiltration, and protein level increase in a rat model. This study reveals the potential of BHA in treating inflammatory arthritis.
Article
Neurosciences
Jian-wei Ge, Shi-ji Deng, Zhi-wei Xue, Pin-yi Liu, Lin-jie Yu, Jiang-nan Li, Sheng-nan Xia, Yue Gu, Xin-yu Bao, Zhen Lan, Yun Xu, Xiao-lei Zhu
Summary: The research suggests that imperatorin can suppress neuroinflammation, alleviate ischemic injury, and exert protective effects by downregulating the MAPK and NF-kappa B signaling pathways.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Engineering, Chemical
Ji-Woong Park, Woong Kim, Chul Yung Choi, Seok-Jun Kim
Summary: The study found that RLE effectively suppressed the inflammatory response induced by LPS in BV-2 cells, suggesting its potential use as a preventive agent against diseases triggered by microglial inflammatory responses.
Review
Cell Biology
Flaviana Marzano, Luisa Guerrini, Graziano Pesole, Elisabetta Sbisa, Apollonia Tullo
Summary: TRIM8, a member of the TRIM protein family, plays crucial roles in immune response, carcinogenesis, and cell survival, among other biological processes. Apart from its ubiquitination functions, TRIM8 can act as either an oncogene or a tumor suppressor gene, selectively regulating three pivotal cellular signaling pathways.
Article
Biochemistry & Molecular Biology
Jae Kwang Kim, Hye Jin Yang, Younghoon Go
Summary: Quercus acuta Thunb. extract shows significant anti-neuroinflammatory effects by inhibiting NF-kappa B and MAPK activation, and activating Nrf2/HO-1 signaling pathways, suggesting its potential in preventing microglia-mediated neuroinflammation.
Article
Immunology
Chenchen Liu, Wei Zhao, Jia Su, Xiaochun Chen, Feifan Zhao, Jindai Fan, Xiaowen Li, Xiaodi Liu, Linke Zou, Mengru Zhang, Zilin Zhang, Liangliang Zhang, Shuangqi Fan, Yuwan Li, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: Heat shock protein HSP90AA1 plays an important role in classical swine fever virus (CSFV) infection by inhibiting viral replication and activating JAK/STAT and NF-κB signaling pathways through interaction with NS5A protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nazia Afroze, Sreepoorna Pramodh, Jasmin Shafarin, Khuloud Bajbouj, Mawieh Hamad, Madhumitha Kedhari Sundaram, Shafiul Haque, Arif Hussain
Summary: Fisetin inhibits cell proliferation, promotes apoptosis, and improves oxidative stress and inflammation through regulating various signaling pathways, suggesting its potential therapeutic value in cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yanhua Luo, Tahir Ali, Zizhen Liu, Ruyan Gao, Axiang Li, Canyu Yang, Li Ling, Liufang He, Shupeng Li
Summary: EPO has antidepressant potential by inhibiting inflammatory response and regulating JAK2/STAT5 signaling.
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Immunology
Yingchun Su, Yanting Liu, Dewei He, Guiqiu Hu, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Dianfeng Liu
Summary: Parkinson's disease is a common disease caused by degeneration of the central nervous system, characterized by the death of dopaminergic neurons. Neuroinflammation, particularly the excessive activation of microglia, plays a significant role in its pathogenesis. Hordenine has been found to have anti-oxidant and anti-inflammatory properties, and this study reveals its potential in inhibiting neuroinflammation by suppressing microglial activation and protecting dopaminergic neurons.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Na Li, Chun-Yan Yao, Jun Diao, Xiao-Ling Liu, En-Jie Tang, Qing-Song Huang, Yu-Meng Zhou, Yue-Gu Hu, Xiu-Kuan Li, Jin-Yun Long, Hua Xiao, Da-Wei Li, Ning Du, Ya-Fei Li, Peng Luo, Tong-Jian Cai
Summary: T-2 toxin induces neurotoxicity in mice by activating microglia, leading to behavioral abnormalities. This toxic effect may be mediated through the MAPK/NF-kappa B signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Applied
Hai-Ning Lyu, Ning-Ning Wei, Peng-Fei Tu, KeWei Wang, Yong Jiang
NATURAL PRODUCT RESEARCH
(2020)
Article
Plant Sciences
Jing-Kang Wang, Qiang Guo, Xiao-Wen Zhang, Li-Chao Wang, Qian Liu, Peng-Fei Tu, Yong Jiang, Ke-Wu Zeng
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Chemistry, Analytical
Jin-Yang Song, Jin-Feng Chen, Ying-Yuan Lu, Kun Chang, Ming-Bo Zhao, Peng-Fei Tu, Yong Jiang, Xiao-Yu Guo
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Biochemistry & Molecular Biology
Yang Liu, Heng Yang, Qiang Guo, Tingting Liu, Yong Jiang, Mingbo Zhao, Kewu Zeng, Pengfei Tu
Article
Plant Sciences
Qixin Wang, Jianteng Dong, Wenji Lu, Hao He, Xiaoqian Sun, Ke Zhang, Qingqing Song, Yong Jiang, Yong Wang, Chun Li, Pengfei Tu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Plant Sciences
Xiaoping Wang, Hui Meng, Qixin Wang, Mingyan Shao, Wenji Lu, Xu Chen, Yong Jiang, Chun Li, Yong Wang, Pengfei Tu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Peng Gao, Ling Wang, Lin Zhao, Qing-ying Zhang, Ke-wu Zeng, Ming-bo Zhao, Yong Jiang, Peng-fei Tu, Xiao-yu Guo
Article
Biochemistry & Molecular Biology
Haizhen Liang, Nankai Cao, Kewu Zeng, Mingbo Zhao, Pengfei Tu, Yong Jiang
Article
Plant Sciences
Nan-Kai Cao, Si-Si Zhu, Yue-Mei Chen, Xiao-Li Ma, Ming-Bo Zhao, Jun Li, Peng-Fei Tu, Yong Jiang
Summary: A new prenylated coumarin diglycoside and five known flavonoid glycosides were isolated from the leaves and stems of Clausena dunniana. These compounds were evaluated for their insulin-release promoting effects, with compounds 1, 2, and 4 exhibiting significant activities at 40 µM.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiaoli Ma, Hongwei Chen, Sisi Zhu, Pengfei Tu, Yong Jiang
Summary: In this study, seventeen new carbazole alkaloid derivatives were isolated from the leaves and stems of Murraya microphylla, including trimeric and dimeric carbazole racemates. The structures of the new compounds were elucidated using HRESIMS and NMR data analysis, and the optically pure isomers were obtained through chiral HPLC separation.
Article
Plant Sciences
Mengqiu Lu, Zhiyong Du, Shuo Yuan, Qing Ma, Zhenzhou Han, Pengfei Tu, Yong Jiang
Summary: This study compared the effects of Murraya exotica L. and Murraya paniculata (L.) Jack on gastric lesions in rats and found that they have similar effects on improving gastric lesions and reducing inflammation and digestion related cytokine levels. Metabolomics results showed abnormalities in lipid, energy, and amino acid metabolism in rats with gastric lesions, and both plants demonstrated a similar metabolic modulation for gastric lesions. The study concluded that using both plants as the source plants of Murrayae Folium et Cacumen is feasible and reasonable for treating gastric lesions due to their similar pharmacodynamics and metabolic modulation ability. The combination of pharmacodynamics and metabolomics was also shown to be an efficient means for studying multi-source traditional Chinese medicine.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Si-Si Zhu, Yi-Fan Zhang, Meng Ding, Ke-Wu Zeng, Peng-Fei Tu, Yong Jiang
Summary: This study found that Clausena lenis Drake can be used as a traditional herbal medicine to treat various diseases, and identified the inhibitory activity of its compounds on BV-2 microglial cells, with the new compounds having significant effects on nitric oxide production.
Article
Biochemistry & Molecular Biology
Chao-Hua Li, Ying Zhou, Peng-Fei Tu, Ke-Wu Zeng, Yong Jiang
Summary: It was found that the carbazole alkaloid obtained from medicinal plants has a significant anti-neuroinflammation effect by directly targeting Sp1 and inhibiting NF-κB and MAPK signaling pathways.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Meng Fang, Yuqing Meng, Zhiyong Du, Mengqiu Guo, Yong Jiang, Pengfei Tu, Kun Hua, Yingyuan Lu, Xiaoyu Guo
Summary: The combination of Notoginseng and safflower shows a synergistic therapeutic effect on myocardial infarction by improving myocardial damage, apoptosis, oxidative stress, and inflammation. The study provides a theoretical basis for the clinical development of this combination.
Article
Biochemistry & Molecular Biology
Peng Gao, Kun Chang, Shuo Yuan, Yanhang Wang, Kewu Zeng, Yong Jiang, Pengfei Tu, Yingyuan Lu, Xiaoyu Guo
Summary: This study explored the mechanism and substance bases of Dictamnus dasycarpus Turcz hepatotoxicity using network pharmacology and molecular docking, verified through pharmacological experiments. The targets of DC included CYP1A2 and GSR, participating in various metabolic processes such as steroid metabolism, REDOX metabolism, and drug metabolism. In vitro and in vivo experiments confirmed that DC could induce hepatotoxicity by decreasing GSH-Px and inducing oxidative stress, as well as inhibiting the expression of CYP1A2.