期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 17, 页码 8011-8021出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.07.068
关键词
Alzheimer's disease; acetylcholinesterase inhibitor; design; synthesis; coumarin
资金
- Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of MOE, P. R. China
Three series (series A-C) of coumarin analogues with phenylpiperazine functions as substitution were designed and synthesized for studying their potential for treating Alzheimer's (AD) disease. Their anticholinesterase activities were assayed according to Ellmann's method against freshly prepared acetylcholinesterase (AChE) from Electrophorus electricus using donepezil as the reference compound. Pharmacological study and preliminary structure-activity relationships showed that coumarins with substitution on positions 3 and/or 4 have parallel anti-AchE activities compared with the reference compound. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据